A5034545707- Liver Disease Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Diet, Metabolism, and Disease
- Nitric Oxide and Endothelin Effects
- Gastrointestinal motility and disorders
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Gut microbiota and health
Amsterdam University Medical Centers
2024-2025
Amsterdam University of the Arts
2025
University of Amsterdam
2019-2025
Background The spectrum of metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent, affecting 30% the world’s population, with a significant risk hepatic and cardiometabolic complications. Different stages MASLD are accompanied by distinct gut microbial profiles, several components have been implicated in pathophysiology. Indeed, earlier studies demonstrated that necroinflammation was reduced individuals after allogenic faecal microbiota transplantation (FMT)...
Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a growing health problem for which no therapy exists to date. The modulation of the gut microbiome may have treatment potential MASLD. Here, we investigated Anaerobutyricum soehngenii, butyrate-producing anaerobic bacterium with beneficial effects in metabolic syndrome, diet-induced MASLD mouse model. Male C57BL/6J mice received Western-type high-fat diet and water 15% fructose (WDF) induce were gavaged A. soehngenii (108 or...
Remote ischemic preconditioning protects peripheral organs against prolonged ischemia/reperfusion injury via circulating protective factors. Preconditioning with helium protected healthy volunteers postischemic endothelial dysfunction. We investigated whether plasma from helium-treated can protect human umbilical vein cells (HUVECs) hypoxia in vitro through release of factors.Healthy male inhaled heliox (79% helium, 21% oxygen) or air for 30 min. Plasma was collected at baseline, directly...