A5021218675- Nanoparticles: synthesis and applications
- Alcohol Consumption and Health Effects
- Single-cell and spatial transcriptomics
- Neuroinflammation and Neurodegeneration Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Liver physiology and pathology
- Characterization and Applications of Magnetic Nanoparticles
- Blood properties and coagulation
- Cancer, Hypoxia, and Metabolism
- Statistical and Computational Modeling
- Nanoparticle-Based Drug Delivery
- Digital Imaging for Blood Diseases
- Platelet Disorders and Treatments
- Immune responses and vaccinations
- Gold and Silver Nanoparticles Synthesis and Applications
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Liver Diseases and Immunity
Hanyang University
2020-2024
Korea Research Institute of Bioscience and Biotechnology
2024
Dysregulation of liver sinusoidal endothelial cell (LSEC) differentiation and function has been reported in alcohol-associated disease (ALD).Impaired nitric oxide (NO) production stimulates LSEC capillarization dysfunction; however, the mechanism underlying NO remains unclear.Here, we investigated role thioredoxin-interacting protein (TXNIP), an important regulator redox homeostasis, its subsequent effects on ALD progression.We found that hepatic TXNIP expression was upregulated patients...
The number of patients with liver diseases has increased significantly the progress global industrialization. Hepatic fibrosis, one most common diagnosed in many developed countries, occurs response to chronic injury and is primarily driven by development inflammation. Earlier immunological studies have been focused on importance innate immune pathophysiology steatohepatitis but recently, it also reported that adaptive immunity, particularly B cells, plays an essential role hepatic...
Understanding how nanoparticles (NPs) interact with biological systems is important in many biomedical research areas. However, the heterogeneous nature of systems, including existence numerous cell types and multitudes key environmental factors, makes these interactions extremely challenging to investigate precisely. Here, using a single-cell-based, high-dimensional mass cytometry approach, we demonstrated that presence protein corona has significant influences on cellular associations...
In the field of nanotechnology, analytical characterization plays a vital role in understanding behavior and toxicity nanomaterials (NMs). Characterization needs to be thorough technique chosen should well-suited property determined, material being analyzed medium which it is present. Furthermore, instrument operation methodology need well-developed clearly understood by user avoid data collection errors. Any discrepancies applied method or procedure can lead differences poor reproducibility...
Understanding the sepsis-induced immunological response can be facilitated by identifying phenotypic changes in immune cells at single-cell level. Mass cytometry, a novel multiparametric analysis technique, offers considerable benefits characterizing peripheral blood mononuclear cells. Here, we analyzed from 20 sepsis patients and 10 healthy donors using mass cytometry employing 23 markers. Both manual gating automated clustering approaches (PhenoGraph) were used for cell identification,...
Abstract Background Age-dependent immune responses to coronavirus disease 2019 (COVID-19) vaccinations and breakthrough infections (BIs) in young middle-aged individuals are unclear. Methods This nationwide multicenter prospective cohort study analyzed participants of the ChAdOx1 (ChAd)-ChAd-mRNA vaccine group using cytometry by time-of-flight, anti-spike protein antibody (Sab) anti-nucleocapsid (Nab) titers, plaque reduction neutralization tests (PRNTs), interferon-gamma (IFN-γ) release...
In the field of nanotechnology, analytical characterization plays a vital role in understanding behavior and toxicity nanomaterials (NMs). Characterization needs to be thorough technique chosen should well-suited property determined, material being analyzed medium which it is present. Furthermore, instrument operation methodology need well-developed clearly understood by user avoid data collection errors. Any discrepancies applied method or procedure can lead differences poor reproducibility...
Platelets and their subcellular components (e.g., dense granules) are essential in hemostasis. Understanding chemical heterogeneities at the sub-micrometer scale, particularly activation during hemostasis production of platelet-derived extracellular vesicles, may provide important insights into mechanisms; however, this has rarely been investigated, mainly owing to lack appropriate characterization tools nanometer scale. Here, use scanning transmission X-ray microscopy (STXM) combined with...