A5108330073- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Hydrology and Watershed Management Studies
- Regional Development and Environment
- Inflammatory mediators and NSAID effects
- Protease and Inhibitor Mechanisms
- Osteoarthritis Treatment and Mechanisms
- Environmental and Agricultural Sciences
- Water Quality Monitoring and Analysis
Shaanxi Normal University
2024
Nanjing Drum Tower Hospital
2024
National Clinical Research Center for Digestive Diseases
2024
Nanjing University
2024
Tongji University
2014
Reactive astrocytes play critical roles in the occurrence of various neurological diseases such as multiple sclerosis. Activation is often accompanied by a glycolysis-dominant metabolic switch. However, role and molecular mechanism reprogramming activation have not been clarified. Here, we found that PKM2, rate-limiting enzyme glycolysis, displayed nuclear translocation EAE (experimental autoimmune encephalomyelitis) mice, an animal model Prevention PKM2 import DASA-58 significantly reduced...
Reactive astrocytes play critical roles in the occurrence of various neurological diseases such as multiple sclerosis. Activation is often accompanied by a glycolysis-dominant metabolic switch. However, role and molecular mechanism reprogramming activation have not been clarified. Here, we found that PKM2, rate-limiting enzyme glycolysis, displayed nuclear translocation EAE (experimental autoimmune encephalomyelitis) mice, an animal model Prevention PKM2 import DASA-58 significantly reduced...
Osteoarthritis (OA) is a highly incident total joint degenerative disease with cartilage degeneration as the primary pathogenesis. The matrix mainly composed of collagen, protein hallmark triple-helix structure, which unfolds collagen degradation on surface. A hybridizing peptide (CHP) synthetic that binds denatured triple helix, conferring potential disease-targeting possibility for early-stage OA. Here, we constructed an albumin nanoparticle (An) conjugated CHP, loaded...
Abstract Reactive astrocytes play critical roles in the occurrence of various neurological diseases such as multiple sclerosis. Activation is often accompanied by a glycolysis-dominant metabolic switch. However, role and molecular mechanism reprogramming activation have not been clarified. Here, we found that PKM2, notoriously known rate-limiting enzyme glycolysis, displayed nuclear translocation EAE (experimental autoimmune encephalomyelitis) mice, an animal model Prevention PKM2 import...
Reactive astrocytes play critical roles in the occurrence of various neurological diseases such as multiple sclerosis. Activation is often accompanied by a glycolysis-dominant metabolic switch. However, role and molecular mechanism reprogramming activation have not been clarified. Here, we found that PKM2, notoriously known rate-limiting enzyme glycolysis, displayed nuclear translocation EAE (experimental autoimmune encephalomyelitis) mice, an animal model Prevention PKM2 import DASA-58...
Reactive astrocytes play critical roles in the occurrence of various neurological diseases such as multiple sclerosis. Activation is often accompanied by a glycolysis-dominant metabolic switch. However, role and molecular mechanism reprogramming activation have not been clarified. Here, we found that PKM2, notoriously known rate-limiting enzyme glycolysis, displayed nuclear translocation EAE (experimental autoimmune encephalomyelitis) mice, an animal model Prevention PKM2 import DASA-58...