A5001798074- Tuberculosis Research and Epidemiology
- Pain Mechanisms and Treatments
- Parasites and Host Interactions
- Neuropeptides and Animal Physiology
- Immunodeficiency and Autoimmune Disorders
- Calcium signaling and nucleotide metabolism
- Antimicrobial Resistance in Staphylococcus
- Anesthesia and Pain Management
- Pharmacological Effects and Toxicity Studies
- Dermatology and Skin Diseases
- Pain Management and Opioid Use
- Streptococcal Infections and Treatments
- Immune Cell Function and Interaction
- Bacterial biofilms and quorum sensing
- Infectious Diseases and Tuberculosis
- Allergic Rhinitis and Sensitization
- Mast cells and histamine
- Cytomegalovirus and herpesvirus research
- Immune responses and vaccinations
- Mycobacterium research and diagnosis
Universidade Federal de Santa Catarina
2013-2024
Abstract Retinoic acid (RA) is a fundamental vitamin A metabolite involved in regulating immune responses through the nuclear RA receptor (RAR) and retinoid X receptor. While performing experiments using THP-1 cells as model for Mycobacterium tuberculosis infection, we observed that serum-supplemented cultures displayed high levels of baseline RAR activation presence live, but not heat-killed, bacteria, suggesting M. robustly induces endogenous pathway. Using vitro vivo models, have further...
Proinflammatory cytokines are critical mediators that control Mycobacterium tuberculosis (Mtb) growth during active (ATB). To further inhibit bacterial proliferation in diseased individuals, drug inhibitors of cell wall synthesis such as isoniazid (INH) employed. However, whether INH presents an indirect effect on by regulating host ATB is not well known. examine this hypothesis, we used vitro human granuloma system generated with primary leukocytes from healthy donors adapted to model ATB....
BACKGROUND: Histamine receptors are known to participate in spinal cord nociceptive transmission, and previous studies have suggested that histaminergic involved the analgesic effects of morphine. Herein, we investigated effect intrathecal injection agonists antagonists a model acute articular inflammation their interaction with METHODS: After carrageenan right knee joint, incapacitation was measured hourly, for up 6 hours, by paw elevation time during 1-minute periods stimulated walking....