A5101755413- Immune Response and Inflammation
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Antifungal resistance and susceptibility
- T-cell and B-cell Immunology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Fungal Infections and Studies
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Helicobacter pylori-related gastroenterology studies
- Protein Tyrosine Phosphatases
- Bioactive Compounds and Antitumor Agents
- NF-κB Signaling Pathways
- Polysaccharides and Plant Cell Walls
- Psoriasis: Treatment and Pathogenesis
- Plant-Microbe Interactions and Immunity
- Gastrointestinal motility and disorders
- Pancreatic and Hepatic Oncology Research
- Signaling Pathways in Disease
- Hematopoietic Stem Cell Transplantation
- Melanoma and MAPK Pathways
- Protein Kinase Regulation and GTPase Signaling
- Galectins and Cancer Biology
- Inflammasome and immune disorders
- Angiogenesis and VEGF in Cancer
Memorial Sloan Kettering Cancer Center
2018-2024
Nanchang University
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Institut Pasteur of Shanghai
2010-2021
University of Chinese Academy of Sciences
2017-2021
Center for Excellence in Molecular Cell Science
2017-2021
Chinese Academy of Sciences
2010-2020
Yangzhou University
2020
Shanghai Institutes for Biological Sciences
2010-2011
Tissue-resident macrophages can self-maintain without contribution of adult hematopoiesis. Herein we show that tissue-resident interstitial (Res-TAMs) in mouse lungs contribute to the pool tumor-associated (TAMs) together with CCR2-dependent recruited (MoD-TAMs). Res-TAMs largely correlated tumor cell growth vivo, while MoD-TAMs accumulation was associated enhanced spreading. Both subsets were depleted after chemotherapy, but rapidly recovered and performed phagocytosis-mediated clearance....
Macrophage activation is controlled by a balance between activating and inhibitory receptors
TLR7/9 signals are capable of mounting massive interferon (IFN) response in plasmacytoid dendritic cells (pDCs) immediately after viral infection, yet the involvement epigenetic regulation this process has not been documented. Here, we report that zinc finger CXXC family regulator CXXC5 is highly expressed pDCs, where it plays a crucial role TLR7/9- and virus-induced IFN response. Notably, genetic ablation resulted aberrant methylation CpG-containing island (CGI) within Irf7 gene impaired...
Abstract Candida albicans can switch from commensal to pathogenic mode, causing mucosal or disseminated candidiasis. The host relies on pattern-recognition receptors including Toll-like (TLRs) and C-type lectin (CLRs) sense invading fungal pathogens launch immune defense mechanisms. However, the complex interplay between fungus innate immunity remains incompletely understood. Here we report that C . upregulates expression of a small secreted cysteine-rich protein Sel1 upon encountering...
Abstract Background Candida albicans is the most common opportunistic human fungal pathogen. The chemokine ligand CXCL1 plays a protective role in infection through recruitment of neutrophils. TRAF1 (tumor necrosis factor-associated factor 1) can be highly induced by proinflammatory stimuli such as LPS and TNF has been implicated septic shock. However, infection, especially remains elusive. Herein, we reveal that suppresses antifungal immune response to intradermal regulation induction...
Human immediate early response 2 (IER2) has been implicated in tumor cell motility and metastasis; however, the underlying mechanisms hepatocellular carcinoma (HCC) metastasis remain to be clarified.In this study, we demonstrate that dysregulation of IER2 was shown HCC clinical samples, expression resulted promotion migration invasion vitro, growth pulmonary vivo.Moreover, showed altered assembly actin cytoskeleton rearrangement.Furthermore, MAPK PI3K/Akt signaling pathways induced by were...
Abstract Candida albicans is the most common, opportunistic human fungal pathogen whose complex interplay with host innate immune system remains incompletely understood. In this study, we revealed that infection macrophages C. triggers prominent cell death, which largely attributed to RIPK3/MLKL–mediated necroptosis. Our results further demonstrated TSC1-mTOR pathway plays a pivotal role in control of macrophage necroptosis upon engaging Dectin-1/2 and TLR-2/4 pathways through components...
Abstract Mammalian hematopoietic cells arise from mesodermal progenitors in a close developmental relationship with endothelium, and along three distinct cell lineages known as primitive, pro-definitive, definitive hematopoiesis. However, the hierarchy between progenitors, blood is incompletely understood. We report here identification mouse gastrula human (h)iPSC cultures of population CXCR4 + primitive streak stage that give rise to yolk sac islands, hematopoiesis, resident macrophages,...
Abstract Fungal infections pose serious health threat worldwide, causing severe mucosal and systemic candidiasis in elderly people, AIDS patients organ recipients. Through sensing fungal cell-wall components b-glucan mannan, C-type lectin receptors (CLRs) dectin-1 dectin-2/3 play pivotal role the induction of anti-fungal innate adaptive immune responses. However, regulatory mechanisms CLR signaling remain to be better understood. Indeed, our previous work demonstrated that protein tyrosine...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal disease and frequently metastasize to liver. The presence macrophages (F4/80+ cells or CD68+ cells) reported correlate with tumor progression metastasis in pancreatic cancer. Emerging evidence has revised traditional concept macrophage ontogeny made it increasingly apparent that there exists functional diversity between resident originating from yolk sac erythro-myeloid progenitors (EMPs) hematopoietic stem...
Abstract Despite being a commensal for healthy individuals, Candida albicans can rapidly switch to pathogenic mode featured with hyphal development, altered cell wall composition and secreted virulence factors, thereby causing mucosal or disseminated candidiasis in immunocompromised patients. The host relies on diversity of pattern-recognition receptors, particularly Toll-like receptors (TLRs) C-type lectin (CLRs) sense invading fungal pathogens launch immune defense mechanisms. However, the...