A5083935690- Occupational and environmental lung diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Biochemical Acid Research Studies
- Glutathione Transferases and Polymorphisms
- Occupational exposure and asthma
- Autophagy in Disease and Therapy
- Macrophage Migration Inhibitory Factor
- Inflammasome and immune disorders
- Magnolia and Illicium research
- NF-κB Signaling Pathways
- Pharmacological Effects of Natural Compounds
- interferon and immune responses
- Biomarkers in Disease Mechanisms
- Bipolar Disorder and Treatment
- Arsenic contamination and mitigation
- TGF-β signaling in diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Topic Modeling
- Microbial metabolism and enzyme function
- Biomedical Text Mining and Ontologies
- Metabolism, Diabetes, and Cancer
- Fungal Biology and Applications
- Air Quality and Health Impacts
- Amyotrophic Lateral Sclerosis Research
- Chromium effects and bioremediation
Xinxiang Medical University
2020-2024
North China University of Science and Technology
2021-2024
Silicosis, characterized by interstitial lung inflammation and fibrosis, poses a significant health threat. ATII cells play crucial role in alveolar epithelial repair structural integrity maintenance. Inhibiting cell senescence has shown promise silicosis treatment. However, the mechanism behind silica-induced remains elusive. The study employed male C57BL/6 N mice A549 human to investigate its potential Silicosis was induced via intratracheal instillation of crystalline silica particles,...
Inhalation of silica particles (SiO2) causes oxidative stress-induced inflammation and cell apoptosis, ultimately resulting in irreversible pulmonary fibrosis, Unfortunately, effective treatment or preventative measures have yet to be fully established. Metformin (Met), a relatively safe medication for treating diabetes, may hold promise as protective agent against early-stage fibrosis mice through the activation autophagy inhibition endothelial mesenchymal transition (EndoMT). Here, we...
Purpose: The objective of this study was to evaluate and compare the histopathological implications silica nanoparticles (Nano-SiO 2 ) indium-tin oxide (Nano-ITO), in vivo. Methods: Male Sprague-Dawley rats were exposed Nano-SiO (50 mg/kg) Nano-ITO (6 by a single intratracheal instillation, respectively. Broncho-alveolar lavage fluid (BALF) lung tissue obtained at 7, 14, 28, 56 days post exposure for analysis BALF inflammatory factors, total protein, pathology. Histopathological...
Silicosis is a severe progressive lung disease without effective treatment methods. Previous evidence has demonstrated that endothelial cell to mesenchymal transition (EndoMT) plays an essential role in pulmonary fibrosis, and fibrosis associated with dysregulation of autophagy, while the relationship between autophagy EndoMT not yet been adequately studied. Herein, we established mouse model silicosis, found pharmacological induction AMPK/mTOR-dependent pathway using 100 mg/kg Metformin...
Abstract Silicon dioxide (SiO 2 )‐induced pulmonary fibrosis is potentially associated with the impairment of mitochondrial function. Previous research found that inhibition macrophage receptor collagenous structure (MARCO) could alleviate particle‐induced lung injury by regulating phagocytosis and mitigating damage. The present study aims to explore underlying anti‐fibrosis mechanism polyguanylic acid (PolyG, MARCO inhibitor) in a silicotic rat model. Hematoxylin eosin Masson staining were...
Silicosis is a systemic disease caused by long-term exposure to high concentrations of free silica dust particles in the workplace. It characterized persistent inflammatory response, fibroblast proliferation, and excessive collagen deposition, leading pulmonary interstitial fibrosis. Epithelial transformation (EMT) can cause epithelial cells lose their tight junctions, cell polarity, properties, thereby enhancing properties cells, which lead progression fibrosis formation scar tissue....
Introduction Diabetic nephropathy (DN) develops in about 40% of patients with type 2 diabetes and remains the leading cause end-stage renal disease. The mechanisms DN remain to be elucidated. Oxidative stress is thought involved development but antioxidant therapy has produced conflicting results. Therefore, we sought define role retarding this study. Research design methods We generated a new antioxidant/diabetes mouse model, Lias H/H Lepr db/db mice, by crossing mice which have...
Silicosis is an occupational lung disease that results from long-term inhalation of free silica dust, the expression sustained inflammation response, fibroblast hyperplasia, and excessive collagen deposit, bringing about pulmonary interstitial fibrosis. Wnt signaling pathway exists in various kinds eukaryotic cells, a highly conservative biological evolution, participates cell proliferation, differentiation, migration, polarity physiological activity, such as embryonic development, organ...
Abstract Background The immunomodulatory abnormalities of silicosis are related to the lymphocyte oxidative stress state. potential effect antioxidant therapy on may depend variation in nuclear factor erythroid 2-related 2 (NRF2)-regulated genes peripheral blood mononuclear cells (PBMCs). As NRF2 is a redox-sensitive transcription factor, its possible roles and underlying mechanism treatment need be clarified. Methods Ninety-two male patients with 87 healthy volunteers were randomly...
Inhalation of silica particles (SiO2) causes oxidative stress-induced inflammation and cell apoptosis, ultimately resulting in irreversible pulmonary fibrosis, Unfortunately, effective treatment or preventative measures have yet to be fully established. Metformin (Met), a relatively safe medication for treating diabetes, may hold promise as protective agent against early-stage fibrosis mice through the activation autophagy inhibition endothelial mesenchymal transition (EndoMT). Here, we...
Abstract BackgroundThe immunomodulatory abnormalities of silicosis are related to the lymphocyte oxidative state. The potential effect antioxidant therapy on may depend variation in nuclear factor erythroid 2-related 2 (NRF2)-regulated genes peripheral blood mononuclear cells (PBMCs). As NRF2 is a redox-sensitive transcription factor, its possible roles and underlying mechanism treatment need be clarified.MethodsIn this study, state was investigated by evaluating expression NRF2-dependent...