Abstract Non-small cell lung cancer, specifically adenocarcinoma, is amenable to targeted therapy for genetic alterations. The role of BRCA mutations in pathogenesis and the efficacy PARP inhibitors these cases are still unclear. This case involves a 61-year-old male patient with past history Hodgkin’s Lymphoma heavy smoking who developed adenocarcinoma was found have BRCA2 mutation. Following disease progression on first-line chemotherapy detailed discussion multidisciplinary team meeting,...

Vaccination is the principal tool aimed at curbing COVID-19 pandemic that has, so far, affected tens of millions individuals in United States. The two available mRNA vaccines developed by Pfizer-BioNTech and Moderna possess high efficacy preventing infection illness severity. However, there are multiple side effects associated with these vaccines, some impacting different organs. Renal pathology variable, increasing cases glomerulonephritis being observed. We report a rare acute kidney...

Variceal bleeding is a key and most fatal complication observed in chronic liver disease patients with portal hypertension major contributor to the high morbidity mortality seen these patients. Exploring predictors of rebleeding paramount importance alter course impact on mortality.About 50 who previously had evidence varices upper GI endoscopy at least one episode after EVBL were included this study. Patients assessed for possible contributors through complete history, clinical examination,...

We present a case of 73-year-old woman with medical history significant for hyperlipidemia, on pravastatin, who developed Takotsubo cardiomyopathy following diagnosis osteoporosis. She presented to the Emergency Department acute transient left arm pain that resolved spontaneously. Investigations revealed elevated troponin levels, non-specific electrocardiographic changes, no coronary artery disease angiography, and ventricular systolic dysfunction, findings consistent cardiomyopathy. Further...

Bevacizumab and atezolizumab combination is one of the preferred combinations for managing advanced hepatocellular carcinoma (HCC), while evidence on monotherapy with either agent not convincing.We present a case man in his 50s diagnosed HCC spinal metastases who showed good response to therapy.However, he developed severe proteinuria hypertension secondary bevacizumab, which had be discontinued after 18 cycles.After an informed decision, was continued patient sustained response.Till date,...

Background and aim: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide.Most patients are diagnosed at an advanced stage, limiting their treatment options.The traditional assessment liver function using the Child-Pugh score has limitations due to its subjectivity.The albumin-bilirubin (ALBI) grade delivers more precise evaluation function.This study examines overall survival (OS) in HCC treated with first-line systemic therapy impact ALBI grading on these...

Objective: To explore relationship between smoking and antiplatelet action of Clopidogrel in patients with ischemic heart disease (IHD). Study Design: Quasi-experimental study Place Duration Study: Department Pharmacology, Army Medical College, National University Sciences, Rawalpindi, Pakistan from Aug 2015 to Dec 2019. Methodology: The quasi experimental was carried out on 390 IHD recruited through convenience sampling. Patients were placed two groups. Group-1 included smokers while...

Objectives: To determine the frequency of spontaneous bacterial peritonitis (SBP) in chronic liver disease patients with ascites using proton pump inhibitors (PPI). Study Design: Prospective cohort study. Setting: Medicine Unit-II, Shalamar Hospital Lahore. Period: From 1st January to 30thJune 2017. Materials & Methods: A total 380 enrolled present study were divided into two groups; PPI group and non group. Each had 190 patients. We performed an extensive matching both groups minimize...

Thakur, Tushar; He, Mingyue; Khan, Waqas Ahmad; Ahmed, Ziauddin; Lee, Iris J. Author Information

Introduction: The frequency of QT interval prolongation as published in the international and local literature has been variable. Aims & Objectives: To determine patients with chronic liver disease resolve variability literature. Place duration study: present study was conducted Gastroenterology Hepatology Unit Shaikh Zayed Hospital Lahore from 1st March 2017 to 31st August 2017. Material Methods: About 240 diagnosed were selected. Electrocardiography (12 lead) performed all look for...

Aim: To compare the efficacy of double dose hepatitis B vaccine with conventional in C related chronic liver disease patients. Study design: Interventional study (randomized controlled clinical trial) Place and duration study: Outpatient Department Medicine, Services Hospital, Lahore from 12th August 2019 to February 2020. Methodology: One hundred ten patients both male female age group 30 70 years diagnosed on basis changed echo texture ultrasound were included. Patients divided into two...

He, Mingyue; Khan, Waqas Ahmad; Lee, Iris J.; Rakhman, Ilay; Constantinescu, Serban Author Information

Shaik, Zakir; Khan, Waqas Ahmad; Rao, Ajay D.; Lee, Jean; Temple University Hospital Author Information