A5102771846- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Olfactory and Sensory Function Studies
- Diet and metabolism studies
- Acute Lymphoblastic Leukemia research
- Autoimmune Neurological Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Pancreatic function and diabetes
- Fatty Acid Research and Health
- Leprosy Research and Treatment
- Receptor Mechanisms and Signaling
- Oral and gingival health research
- Neurological Disease Mechanisms and Treatments
- Iron Metabolism and Disorders
- Neuropeptides and Animal Physiology
- Diabetes Treatment and Management
- Acute Myeloid Leukemia Research
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Nosocomial Infections in ICU
- Drug-Induced Adverse Reactions
- Emergency and Acute Care Studies
- Chronic Myeloid Leukemia Treatments
- Blood donation and transfusion practices
Université Paris Cité
2019-2025
Unit of Functional and Adaptive Biology
2020-2025
Centre National de la Recherche Scientifique
2019-2025
Wellcome/MRC Institute of Metabolic Science
2024
University of Cambridge
2024
Glucose dependent insulinotropic polypeptide (GIP) is well established as an incretin hormone, boosting glucose-dependent insulin secretion. However, whilst anorectic actions of its sister-incretin glucagon-like peptide-1 (GLP-1) are established, a physiological role for GIP in appetite regulation controversial, despite the superior weight loss seen preclinical models and humans with GLP-1/GIP dual receptor agonists compared GLP-1R agonism alone. We generated mouse model which expressing...
Glucagon-like peptide 1 (GLP-1) stimulates insulin secretion and holds significant pharmacological potential. Nevertheless, the regulation of energy homeostasis by centrally-produced GLP-1 remains partially understood. Preproglucagon cells, known to release GLP-1, are found in olfactory bulb (OB). We show that activating receptors (GLP-1R) OB response oral glucose lean diet-induced obese male mice. This is associated with reduced noradrenaline content pancreas blocked an α2-adrenergic...
The olfactory bulb (OB) codes for sensory information and contributes to the control of energy metabolism by regulating foraging cephalic phase responses. Mitral cells are main output neurons OB. glucagon-like peptide-1 (GLP-1)/GLP-1 receptor (GLP-1R) system in OB (GLP-1OB) has been shown be a major regulator mitral cell activity but its function vivo is unclear. Therefore, we investigated role GLP-1OB behavior odor-evoked Cephalic Phase Insulin Release (CPIR).By fluorescent labeling,...
Prokineticin 2 (PROK2) is a hypothalamic neuropeptide that plays critical role in the rhythmicity of physiological functions and inhibits food intake. PROK2 also expressed main olfactory bulb (MOB) as an essential factor for neuro-and morphogenesis. Since MOB was shown to be strongly involved eating behavior, we hypothesized could new target regulation intake energy homeostasis, through its effects MOB. We asked whether associated with pathophysiology obesity, metabolic syndrome (MetS), type...
Objective This study aimed to investigate the effects of a high‐fat diet (HFD) and aging on resting activity‐dependent cerebral blood flow (CBF). Methods To run comparison between obese age‐matched control animals, 6‐week‐old mice were fed either with regular chow or an HFD for 3 months 8 months. Glucose tolerance insulin sensitivity assessed metabolic phenotyping. Resting odor‐evoked CBF at microvascular scale in olfactory bulb (OB) was investigated by multiexposure speckle imaging....
Summary Glucagon-like peptide 1 (GLP-1) stimulates insulin secretion and holds significant pharmacological potential. Nevertheless, the regulation of energy homeostasis by centrally-produced GLP-1 remains partially understood. Preproglucagon cells, known to release GLP-1, are found in olfactory bulb (OB). We demonstrate that activating receptors (GLP-1R) OB response oral glucose lean diet-induced obese mice. This is associated with reduced noradrenaline content pancreas blocked an...
Abstract Obesity is a devastating worldwide metabolic disease, with the highest prevalence in children and adolescence. impacts neuronal function but fate of functional hyperemia, vital mechanism making possible cerebral blood supply to active brain areas, unknown organisms fed high caloric Western Diet (WD) since We mapped changes volume (CBV) somatosensory cortex response whiskers stimulation adolescent, adult middle-aged mice WD To this aim, we used non-invasive high-resolution ultrasound...