A5102728716- Escherichia coli research studies
- Urinary Tract Infections Management
- Pediatric Urology and Nephrology Studies
- Bacteriophages and microbial interactions
- Antibiotic Resistance in Bacteria
- Probiotics and Fermented Foods
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Acute Ischemic Stroke Management
- Kidney Stones and Urolithiasis Treatments
- Colorectal Cancer Screening and Detection
- Intracerebral and Subarachnoid Hemorrhage Research
- Energy Load and Power Forecasting
- Blood properties and coagulation
- Advanced Computational Techniques and Applications
- S100 Proteins and Annexins
- Immunotherapy and Immune Responses
- Photoacoustic and Ultrasonic Imaging
- Temporomandibular Joint Disorders
- CRISPR and Genetic Engineering
- Smart Grid and Power Systems
- Peripheral Neuropathies and Disorders
- Ultrasound and Hyperthermia Applications
- Molecular Biology Techniques and Applications
- Fungal and yeast genetics research
University of Cambridge
2023-2024
Second Hospital of Tianjin Medical University
2012-2023
Tianjin Medical University
2012-2023
State Ethnic Affairs Commission
2023
Southwest Minzu University
2023
Chongqing Medical University
2021-2022
China Design Group (China)
2019
Guizhou Academy of Agricultural Sciences
2016
Yunnan University
2013
Sichuan University
2006-2012
Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections (UTIs), inducing acute pyelonephritis and may result in permanent renal scarring failure. Alpha-hemolysin (HlyA), a key UPEC toxin, causes serious tissue damage; however, mechanism through which HlyA induces kidney injury remains unclear. In present study, granulocyte-macrophage colony-stimulating factor (GM-CSF) secreted by epithelial cells was upregulated vitro vivo, induced M1 macrophage accumulation...
Purpose: Stroke-associated infection (SAI) is associated with adverse outcomes in patients acute ischemic stroke (AIS). In this study, we aimed to evaluate the association between neutrophil percentage-to-albumin ratio (NPAR) and SAI occurrence AIS. Methods: We retrospectively analyzed all AIS who were admitted Neurology ward of The Second Hospital Tianjin Medical University from November 2018 October 2020. relationship NPAR was by multivariable analysis. receiver operating characteristic...
Enhancers bind transcription factors, chromatin regulators, and non-coding transcripts to modulate the expression of target genes. Here, we report 3D genome structures single mouse ES cells as they are induced exit pluripotency transition through a formative stage prior undergoing neuroectodermal differentiation. We find that there is remarkable reorganization structure where inter-chromosomal intermingling increases dramatically in state. This associated with formation large number multiway...
Extraintestinal pathogenic Escherichia coli (ExPEC) can cause many human extraintestinal infections. Resistance and virulence of ExPEC are inextricably linked to its phylogenetic background. However, studies on type-specific distribution resistance the connection between resistance/virulence molecular typing lacking. Here, 411 strains were collected characterized using antimicrobial susceptibility testing typing. Among these, 74 representative selected for whole genome sequencing Galleria...
Mushrooms that are morphologically indistinguishable from Russula virescens (Schaeff.) Fr. among the most popular wild edible mushrooms in Yunnan province, southwestern China. However, almost nothing is known about their biology. This study investigated diversity and population genetics of a R. ally Yunnan. A total 210 samples were collected 13 geographical locations throughout main distribution range The patterns genetic variation within these geographic populations analyzed using sequences...
BackgroundUropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections (UTIs), and fimbrial tip adhesins, play important roles in UPEC colonization. Few adhesins their receptors on host cells, which have potential to be therapeutic targets, been identified.Methodsthe wild-type strain CFT073, ΔyadC complemented were used perform assays vitro vivo. The effects D-xylose targeting YadC colonization evaluated. A receptor was identified by far-western blotting, LC-MS/MS...
Midstream urine specimen cultures play an important role in assisting clinicians to choose antibiotics remove urinary tract pathogens. At present, there are many culture methods for obtaining midstream specimens. In this article, different were compared improve the detection rate of pathogenic bacteria patients with infections (UTIs).Urina sanguinis specimens collected from 90 outpatients and inpatients who had UTI symptoms, been clinically diagnosed between February March 2021, tested...
Purpose: To evaluate the association between neutrophil-to-lymphocyte ratio (NLR) and stroke-associated pneumonia (SAP) in patients with acute ischemic stroke (AIS) without fever to clarify whether NLR has an advantage over high-sensitivity C-reactive protein (hs-CRP) predicting SAP. Patients Methods: A total of 434 AIS were assessed this study. Multivariable analysis was used relationship SAP, receiver operating characteristic (ROC) curve compare predictive value hs-CRP. Results: Among...
Aspergillus chevalieri var. intermedius is a dominant filamentous fungal species in Fuzhuan tea and associated with the quality health benefits of this tea. The sexual or asexual reproduction fungus depends on osmotic pressure Efforts to enhance beneficial effects A. are hampered by difficulties disrupting its genes. To address issue, we identified homolog (Acku70) human Ku70 generated an Acku70 disruption strain (ΔAcku70), aiming improve gene replacement efficiency. ΔAcku70 grew at slightly...
The different grading systems for diabetic foot disease pose a challenge in clinical decision making because each system fails to accurately reflect the individual course of progression. This study attempts identify laboratory measurements classifying guide treatment.The sera 111 clinically graded patients were measured several parameters including serum amyloid A (SAA), C-reactive protein (CRP), and apo A-I. By using molar sum CRP SAA then dividing by molarity A-I, an acute phase index was...
<p>Functional and sensory augmentation of living structures, such as the human skin plant epidermis, offers vast opportunities for biology-machine interface, wearable health, environmental monitoring. However, current sensor electronic formats could be obstructive to their hosts’ inherent sensations or physiological changes. Challenges are also faced in widening structures without drastically increasing global ecological burdens. Here, we demonstrate imperceptibly augmented systems,...
Abstract With the development of China’s economy and society, demand for electric energy is gradually increasing, large-scale investment in power grid infrastructure projects being made. Due to unreasonable plan, balance rate enterprises recent years higher, which not conducive scientific management enterprises. Therefore, it necessary make prediction order achieve rational control projects. Based on BP neural network, this paper establishes model projects, chooses factors that have great...
Urinary tract infections (UTIs) are one of the most common infectious diseases. UTIs mainly caused by uropathogenic Escherichia coli (UPEC), and either upper or lower according to infection site. Fimbriae necessary for UPEC adhere host uroepithelium, abundant diverse in strains. Although great progress has been made determining roles different types fimbriae colonization, contributions multiple site-specific attachment also need be considered. Therefore, distribution patterns 22 fimbrial...
Objective To study drug resistance of carbapenem-resistant Klebsiella pneumonia (CRKP) in neonates hospitalized the neonatal unit, and to identify risk factors for CRKP colonization neonates. Methods Totally 108 with admitted Department Neonates, Second Hospital Tianjin Medical University during January 2012 June 2014 were enrolled study, including 23 cases (case group) 85 carbapenem-sensitive (CSKP) (control group). Chi-square test fisher exact used compare differences 21 antibiotics...
Objective To investigate the existence of beta-lactamases(bla) genes,aminoglycosides-modifying enzymes(AMEs) genes,integrase genes and quinolone-resistance in pan-drug resistant Acinetobacter baumannii (PDR-AB) study consanguinity among strains isolated from clinical samples region.Methods Drug-resistance 50 PDR-AB were analyzed by PCR verified DNA sequencing.The construction tree structured consanguinty detected DNAMAN software.Results The positive rates...
Objective To investigate the molecular epidemiological characteristics of extraintestinal pathogenic E.coli (ExPEC) clinical isolates by firstly detecting their 30 known virulence factors and phylogenetic groups A,B1,B2 D,secondly analyzing relationship between these groups.Methods A total 210 ExPEC were investigated.Multiplex PCR was performed to detect among 133 strains isolates.For statistical analysis,the comparisons proportions evaluated using Fisher's exact test.Results In this study...
Objective To analyze the clinical features of patients suffering from tumefactive demyelina-ting diseases as well impacts and efficiency administration glucocorticoids. Methods A retrospective review was conducted on 7 cases demyelinating that were treated at Department Neurosurgery, Beijing Ditan Hospital, Capital Medical University Navy General Hospital January 2007 to April 2017. Among them, 6 underwent brain biopsy craniotomy performed in 1. After surgery, we analyzed classified...
Objective To investigate the adhesion levels in uropathogenic Escherichia coli with various degree of drug resistance. Methods One hundred strains isolated from urine specimen were collected patients admitted to 4 Grade A tertiary hospitals Tianjin during March 2012 October 2015. divided into sensitive group and resistant by sensitivity tests 50 each group. The expressions fimH, fimA, fimB genes type I fimbriae papA, papB, papC, papGII P detected polymerase chain reaction(PCR)...