A5088677739- Lung Cancer Diagnosis and Treatment
- Ultrasound Imaging and Elastography
- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Elasticity and Material Modeling
- Breast Cancer Treatment Studies
- Lung Cancer Treatments and Mutations
- Electrical and Bioimpedance Tomography
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Research Studies
- Tendon Structure and Treatment
- Renal and related cancers
- Knee injuries and reconstruction techniques
- Ultrasonics and Acoustic Wave Propagation
- Cardiovascular Function and Risk Factors
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- Total Knee Arthroplasty Outcomes
- Renal cell carcinoma treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Musculoskeletal synovial abnormalities and treatments
- Breast Lesions and Carcinomas
- Global Cancer Incidence and Screening
- Advanced Breast Cancer Therapies
- BRCA gene mutations in cancer
Roswell Park Comprehensive Cancer Center
2012-2024
Columbia University
2006-2007
Myocardial elastography (ME), a radio frequency (RF)-based speckle tracking technique with one-dimensional (1-D) cross correlation and novel recorrelation methods in 2-D search was proposed to estimate fully image 2-1) transmural deformation field detect abnormal cardiac function. A theoretical framework first developed order evaluate the performance of myocardial based on previously 3-D finite-element model canine left ventricle. normal (control) an ischemic (left-circumflex, LCx) model,...
Abstract The anterior cruciate ligament (ACL) functions as a mechanical stabilizer in the tibiofemoral joint, and is most commonly injured knee ligament. To improve clinical outcome of tendon grafts used for ACL reconstructions, our long‐term goal to promote graft–bone integration via regeneration native ligament–bone interface. An understanding strain distribution at this interface crucial functional scaffold design evaluation. Experimental determination, however, has been difficult due...
Robust indices of regional and global cardiac function are a key factor in detection treatment heart disease as well understanding the fundamental mechanisms healthy heart. Myocardial elastography provides noninvasive method for imaging measuring displacement strain myocardium early cardiovascular disease. However, two-dimensional in-plane axial lateral strains measured depend on sonographic view used. This becomes especially critical clinical setting may induce large variations strains,...
AIM:To prospectively compare volumetric intensitymodulated arc therapy (VMAT) and conventional intensity-modulated radiation (IMRT) in coverage of planning target volumes avoidance multiple organs at risk (OARs) patients undergoing definitive chemoradiotherapy for advanced (stage Ⅲ or Ⅳ) squamous cell cancer the head neck. METHODS:Computed tomography scans 20 with tumors larynx, naso-, oroand hypopharynx were planned using IMRT (7 field) VMAT two arcs.Calculated doses to volume (PTV) OAR...
The preferred radiotherapeutic approach for central (CLT) and ultracentral (UCLT) lung tumors is unclear. We assessed the toxicity outcomes of patients with CLT UCLT who underwent definitive five-fraction stereotactic body radiation therapy (SBRT). reviewed charts either or managed SBRT from June 2010–April 2019. were defined as gross tumor volume (GTV) within 2 cm proximal bronchial tree, trachea, mediastinum, aorta, spinal cord. GTV abutting any these structures. Propensity score matching...
Radiation oncology relies on computer software for digital processing and planning. Artificial intelligence (AI) employs algorithms to perform tasks including pattern recognition, decision making problem solving [1]. AI has the potential impact quality of radiotherapy cancer patients [2].
The consequence of cardiac substructure irradiation in patients receiving stereotactic body radiation therapy (SBRT) is not well characterized. We reviewed the charts with central lung tumors managed by definitive SBRT from June 2010-April 2019. All were treated five fractions, typically either 5000 cGy (44.6%) or 5500 (42.2%). Via a multi-patient atlas, fourteen substructures autosegmented, manually and analyzed using dosimetric parameters. A total 83 included median follow up 33.4 months....
The heart is a mechanical pump that electrically driven. We have previously shown the contractility of cardiac muscle can reliably be used in order to assess extent ischemia using myocardial elastography. Myocardial elastography estimates displacement and strain during natural contraction myocardium signal processing techniques on echocardiograms change properties as result disease. In this paper, we showed elastographic estimate image both mechanics electromechanics normal pathological...
In 2010, NCCN incorporated active surveillance (AS) into the Clinical Practice Guidelines in Oncology for Prostate Cancer, and 2012 update serves as an excellent resource with most current evidence regarding treatment options men all stages of disease. However, lack clinical trials that directly compare various modalities or identify best management, especially low-risk prostate cancer, makes decision-making process difficult both patients physicians. Although general agreement exists on...
A current limitation of the implementation myocardial elastography in a clinical setting is difficulty interpreting one-dimensional strain maps due to varying values wall left ventricle (LV). In this paper, we demonstrate robust angle-independent method for 2D on simulated ultrasonic images 3D finite-element analysis (FEA) model LV. Two FEA, control and regionally ischemic, canine left-ventricular models, were used states obtained increments accumulated from end-diastole (ED) end-systole...
The purpose of this study was to evaluate the response actively growing renal masses stereotactic body radiation therapy (SBRT). We retrospectively reviewed our institutional review board-approved kidney database and identified 4 patients who underwent SBRT, 15 Gy dose, for their rapidly masses. Three had a decreased tumor size after treatment by 20.8%, 38.1%, 20%. other patient gain 5.6%. This maintained similar growth rate before SBRT. Mean follow-up time 13.8 months. SBRT represents an...
Standard therapy for stage III non-small cell lung cancer with chemotherapy and conventional radiation has suboptimal outcomes. We hypothesized that a combination of surgery followed by stereotactic body (SBRT) would be safe alternative. Patients IIIA (multistation N2) or IIIB were enrolled from March 2013 to December 2015. The protocol included transcervical extended mediastinal lymphadenectomy (TEMLA) surgical resection, 10 Gy SBRT directed the involved mediastinum/hilar stations and/or...
Despite occurring commonly, the prognoses of second early-stage non-small cell lung cancers (NSCLC) are not well known.The authors retrospectively reviewed charts inoperable patients who underwent thoracic stereotactic body radiation therapy (SBRT) from February 2007 to April 2019. Those with previous small or SBRT treatments for tumors other than NSCLC were excluded. Multivariate Cox regression and a matched pair cohort analyses evaluated undergoing definitive new primary.Of 438 NSCLC, 84...
Several methods have been introduced in the past few years to quantify left-ventricular strain order detect myocardial ischemia and infarction. Myocardial Elastography is one of these methods, which based on ultrasound Radio-Frequency (RF) signal processing at high frame rates for highest precision resolution estimation. elastography estimates displacement during natural contraction myocardium using cross-correlation techniques. We previously shown that imaging allows correct assessment...
The anterior cruciate ligament (ACL) functions as a mechanical stabilizer in the tibiofemoral joint. Over 250,000 Americans each year suffer from ACL ruptures and tears, making most commonly injured knee ligament. A long term goal of our research program is to promote graft-bone integration via regeneration native ligament-bone interface. To this end, we have focused on design biomimetic scaffolds combined with tissue engineering induce organized interface regeneration. An understanding...