A5012505646- Animal Disease Management and Epidemiology
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- interferon and immune responses
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Microbial infections and disease research
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Animal health and immunology
- Effects of Environmental Stressors on Livestock
- Pediatric health and respiratory diseases
- CAR-T cell therapy research
- Tracheal and airway disorders
- Cancer-related molecular mechanisms research
- Clostridium difficile and Clostridium perfringens research
- T-cell and Retrovirus Studies
- Peptidase Inhibition and Analysis
- Animal Genetics and Reproduction
University of Louisiana at Lafayette
2019-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2023
Virologie et Immunologie Moléculaires
2021-2023
Université de Versailles Saint-Quentin-en-Yvelines
2022
Université Paris-Saclay
2022
Authorization of the Matrix-M (MM)–adjuvanted R21 vaccine by three countries and its subsequent endorsement World Health Organization for malaria prevention in children are a milestone fight against malaria. Yet, our understanding innate adaptive immune responses elicited this remains limited. Here, we compared clinically relevant adjuvants [3M-052 + aluminum hydroxide (Alum) (3M), TLR7/8 agonist formulated Alum; GLA-LSQ, TLR4 liposomes with QS-21; MM, now-approved adjuvant R21] their...
Respiratory syncytial virus (RSV) is a public health concern that causes acute lower respiratory tract infection. So far, no vaccine candidate under development has reached the market and only licensed product to prevent RSV infection in at-risk infants young children monoclonal antibody (Synagis®). Polyclonal human anti-RSV hyper-immune immunoglobulins (Igs) have also been used but were superseded by Synagis® owing their low titer large infused volume. Here we report new drug class of...
Les maladies respiratoires, qu’elles touchent les animaux et/ou hommes, ont un impact sanitaire et économique considérable sur notre société. Pouvoir mieux contrôler, traiter prédire, nécessite de pouvoir étudier. Pour cela des modèles d’études pertinents, reproductibles, efficaces aisés d’utilisation, alternatifs à l’expérimentation animale doivent être proposés. D’énormes progrès méthodologiques été réalisés ces dernières années avec l’émergence in vitro qui miment le poumon en...
Respiratory Syncytial Virus (RSV) is the major cause of lower respiratory tract infection in infants, whom, sensing RSV by innate immune receptors and its regulation are still poorly described. However, severe bronchiolitis following neonates has been associated with a defect type I interferons (IFN-I) production, cytokine produced mainly alveolar macrophages (AMs) upon adults. In present study, neonatal C57BL/6 AMs mobilized very weakly IFN-I pathway vitro failed to restrain virus...
In order to investigate the genomic control of innate immune response, concentration levels 14 cytokines produced naturally or in response whole blood stimulation with three pattern recognition receptors agonists were determined 623 Holstein calves enrolled Healthycalf project. The effect immunostimulants and relationship among observed through a principal components analysis, 50K GWAS performed on all cytokine × condition traits. Results showed that most are oriented together following...