A5029845369- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Bone health and treatments
- Gastrointestinal disorders and treatments
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Management of metastatic bone disease
- Multiple and Secondary Primary Cancers
- Inflammatory Biomarkers in Disease Prognosis
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Gallbladder and Bile Duct Disorders
- Cancer Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Helicobacter pylori-related gastroenterology studies
- Biliary and Gastrointestinal Fistulas
- Tea Polyphenols and Effects
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Cerebral Venous Sinus Thrombosis
- Cardiac, Anesthesia and Surgical Outcomes
- Chemotherapy-induced cardiotoxicity and mitigation
Tokyo University of Science
2021-2023
Sapporo City General Hospital
2016-2019
Nishikyushu University
2012
Kanzaki (Japan)
2012
Takeda (France)
2012
Hiroshima University
2006
Yamagata Prefectural Central Hospital
1972
Abstract Background A multicenter prospective observational study evaluated the effect of gastrointestinal cancer chemotherapy with short-term periodic steroid premedication on bone metabolism. Patients and Methods Seventy-four patients undergoing for were studied. The primary endpoints changes in mineral densities (BMDs) metabolic turnover 16 weeks after initiation chemotherapy. BMDs, measured by dual-energy x-ray absorptiometry, serum cross-linked N-telopeptides type I collagen (sNTX),...
Background/Aim: SLC20A1 has been identified as a prognostic marker in ER+ breast cancer. However, the role of expression cancer subtypes other than types remains unclear. Materials and Methods: Genomics datasets were downloaded analyzed, effect knockdown using targeted siRNA on cell viability tumor-sphere formation was assessed. Results: SLC20A1<sup>high</sup> patients with ER+, claudin-low or basal-like cancers showed poor prognoses. treated radiotherapy had clinical outcomes. suppressed...
Few data regarding the incidence of cancer-associated thromboembolism (TE) are available for Asian populations. We investigated TE (TEi) and its risk factors among gastric colorectal cancer (GCC) patients received chemotherapy in a daily practice setting.A retrospective cohort study.A single-institutional study that used from Sapporo City General Hospital, Japan, on treated between January 2008 May 2015.Five hundred Japanese GCC who started to 2015.TE was diagnosed by reviewing all reports...
p62 (also known as sequestosome 1) is involved in cancer progression, and high expression of indicates poor clinical outcome several types. However, the association between gene stem cells (CSCs) breast subtypes remains unclear.In present study, genomic datasets primary (The Cancer Genome Atlas, n=593; Molecular Taxonomy Breast International Consortium, n=2,509) were downloaded. Expression was then examined normal tissues derived from same patients. Kaplan-Meier multivariate Cox regression...
Pancreatic ductal adenocarcinoma (PDAC) is the cancer with poorest prognosis. One of major properties reflecting its poor prognosis high-grade heterogeneity, which leads to insensitivity anticancer treatments. Cancer stem cells (CSCs) acquire phenotypic generating abnormally differentiated by asymmetric cell division. However, detailed mechanism leading heterogeneity largely unknown. Here, we showed that PDAC patients co-upregulation PKCλ and ALDH1A3 had clinical outcome. knockdown DsiRNA in...
High expression of solute carrier family 20 member 1 (SLC20A1) indicates poor clinical outcomes for patients with breast cancer subtypes treated endocrine therapy and radiotherapy. However, the association between SLC20A1 in prostate remains to be determined.Open-source datasets (The Cancer Genome Atlas prostate, Stand Up Cancer-Prostate Foundation Dream Team, The PanCancer Atlas) were downloaded analyzed. was analyzed normal tissue. Survival analysis using Kaplan-Meier curves Cox regression...
Background: Spindle cell squamous carcinoma (SCSC) is a rare and peculiar biphasic malignant neoplasm that occurs mainly in the upper aerodigestive tract. It consists of sarcomatoid proliferation pleomorphic spindle‐shaped cells carcinoma. Methods: Here, we established SCSC line from tumour arisen gingiva. We characterized feature by immunohistochemistry. To know biological feature, examined growth, invasiveness epithelial‐mesenchymal transition markers comparison with oral (OSCC) lines....
【症例】投薬治療抵抗性甲状腺クリーゼに対してCHDFと血漿交換を併用し有効であったので報告する．症例1：33歳，女性，眼球突出，動悸，息切れが出現．甲状腺機能亢進症を疑い入院．ショック状態となり，気管内挿管，IABP・PCPS留置にて状態安定．甲状腺クリーゼと診断し薬物治療を開始するも改善なく，CHDFと血漿交換により改善した．症例2：28歳，男性，浮腫，高熱，全身倦怠で受診．入院後ショック状態となりPCPS・IABP留置，気管内挿管後，甲状腺クリーゼに対し薬物療法を開始するも改善なく，CHDFと血漿交換により改善した．【考案】T4の半減期は約7日で，蛋白結合物質であるので除去には血漿交換が有用と考えられ，薬物療法にCHDF＋血漿交換の併用により改善した．【まとめ】甲状腺クリーゼに対してCHDF＋血漿交換は甲状腺機能の早期改善に有用であると考えられた．
e15156 Background: We previously reported that TE incidence (TEi) was 14 % among Japanese gastrointestinal tract cancer (GTC) patients (pts) receiving chemotherapy (CTx), and it significantly higher in multiple primary (MP) pts compared with single (SP) (ASCO-GI 2016 Abst.541). now update the results report associations between TEi MP a organ (MPS) or organs (MPM), influence of on overall survival (OS). Methods: All received CTx for GTC our institution from January 2008 to May 2015 were...
e18145 Background: Although glucocorticoid (GC) premedication (GCP) before chemotherapy (CTx) are frequently used to prevent nausea and vomiting for continuing comfortable CTx, the side effects of intermittent GCs on bone health have not yet been reported. We previously reported that GCP caused reduction mineral densities at lumbar spine (BMD-LS) increase turnover markers, such as cross-linked N-telopeptide type I collagen (NTX) alkaline phosphatase (BAP) (ASCO-GI 2016 Abst.523). now report...
523 Background: Although intravenous glucocorticoid (GC) premedication (GCP) before chemotherapy (CTx) are frequently used to prevent nausea and vomiting for continuing comfortable CTx, the side effects of intermittent GCs on bone health have not yet been reported. So we designed a multicenter, prospective, observational study evaluate impact periodic GCP metabolism in gastrointestinal cancer (GIC) patients (pts). Methods: The eligibility criteria were as follows: (i) histologically proven...
541 Background: Although cancer and its treatments are well-recognized risk factors for thromboembolism (TE), such as venous pulmonary TE, there very few data of the incidence associated TE in Asian population. So we conducted a retrospective cohort study to investigate gastrointestinal tract (GTC) patients (pts) receiving chemotherapy Japanese community hospital’s daily practice setting. Methods: All received GTC our hospital from January 2008 May 2015 were identified through medical...