A5110271239- Advanced Neuroimaging Techniques and Applications
- Epilepsy research and treatment
- Fetal and Pediatric Neurological Disorders
- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Spinal Dysraphism and Malformations
- Autism Spectrum Disorder Research
- Radiopharmaceutical Chemistry and Applications
- Diet and metabolism studies
- Corneal surgery and disorders
- Neurological disorders and treatments
- Neonatal and fetal brain pathology
- Radiomics and Machine Learning in Medical Imaging
- Functional Brain Connectivity Studies
- Cerebral Palsy and Movement Disorders
- Genetics and Neurodevelopmental Disorders
- Language Development and Disorders
- Advanced Text Analysis Techniques
- Drug Transport and Resistance Mechanisms
- Metabolism and Genetic Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ophthalmology and Visual Impairment Studies
- Vascular Malformations and Hemangiomas
National Institute of Technology Warangal
2025
Wayne State University
2010-2022
Children's Hospital of Michigan
2008-2022
Johns Hopkins Hospital
2022
Johns Hopkins University
2022
Detroit Medical Center
2009-2014
Universidad Metropolitana
2014
University of Arkansas for Medical Sciences
2013
Arkansas Children's Hospital
2013
University of South Australia
2008
To investigate frontal lobe white matter in children with autism spectrum disorder (ASD), we performed diffusion tensor imaging (DTI) 50 ASD (mean age: 57.5 ± 29.2 months, 43 males) and 16 typically developing 82.1 41.4 11 males). The apparent coefficient (ADC) was significantly higher for whole (P = 0.011), long < 0.001) short range 0.0126) association fibers group. There a trend toward statistical significance the fractional anisotropy (FA) of 0.11). FA lower group 0.0031) but not...
Although it has been believed that brown adipose tissue (BAT) depots disappear shortly after the perinatal period in humans, PET imaging using glucose analog <sup>18</sup>F-FDG shown unequivocally existence of functional BAT adult suggesting many humans retain some past infancy. The objective this study was to determine what extent thermogenesis is activated adults during cold stress and establish relationship between oxidative metabolism tracer uptake. <b>Methods:</b> Twenty-five healthy...
Major frontal lobe tracts and corpus callosum (CC) were investigated in 32 children with autism spectrum disorder (ASD, mean age: 5 years), 12 nonautistic developmentally impaired (DI, 4.6 16 typically developing (TD, 5.5 years) using diffusion tensor imaging tractography tract-based spatial statistics. Various geometric properties calculated for uncinate fasciculus (UF), inferior fronto-occipital (IFO), arcuate (AF), cingulum (Cg), CC, corticospinal tract. Fractional anisotropy was lower...
ObjectivesTo determine safety and efficacy of the 5HT1A serotonin partial agonist buspirone on core autism associated features in children with spectrum disorder (ASD).Study designChildren 2-6 years age ASD (N = 166) were randomized to receive placebo or 2.5 5.0 mg twice daily. The primary objective was evaluate effects 24 weeks Autism Diagnostic Observation Schedule (ADOS) Composite Total Score. Secondary objectives included evaluating social competence, repetitive behaviors, language,...
We studied the distribution and expression of translocator protein in human brain using (11)C-[R]-PK-11195 positron emission tomography (PK11195 PET) evaluated age-related changes.A dynamic PK11195 PET scan was performed 15 normal healthy adults (mean age: 29 ±8.5 years (range: 20 to 49); 7 males) 10 children 8.8 ±5.2 1.2 17); 5 males), who were for potential neuroinflammation but showed no focally increased binding. The images by calculating standard uptake values regional binding...
This was an observational study done on a large cohort of patients with tuberous sclerosis complex (TSC) to determine whether i) the presence α-[(11)C]-methyl-l-tryptophan (AMT) hotspots is related duration seizure intractability, ii) AMT specific TSC gene mutations, and iii) there concordance between areas hotspot lateralization/localization scalp EEG.One hundred ninety-one (mean age: 6.7 years; median: 5 range: 3 months 37 years) intractable epilepsy were included. All underwent AMT-PET...
To examine the ability of contact lenses coated with fimbrolides, inhibitors bacterial quorum sensing, to prevent microbial adhesion and their safety during short-term clinical assessment.A fimbrolide was covalently attached commercially available high Dk lenses. Subsequently Pseudomonas aeruginosa, Staphylococcus aureus, Serratia marcescens, or Acanthamoeba sp. were added control uncoated Lenses plus microbes incubated for 24 h, then washed thoroughly remove non-adherent microbes. macerated...
Inserting of anterior chamber phakic intraocular lenses are emerging as a transformative option for vision correction, offering individuals with high myopia and thin corneas safe effective solution without compromising the natural lens. Implantation Z-shaped lens fourth generation (ZSAL-4) can change typical flow patterns aqueous humor. To study this patterns, we utilized advanced computational fluid dynamics using Ansys Fluent. This method originated novel approach to measuring...
This research paper introduces a novel mathematical model that integrates fractional calculus with topological data analysis (TDA) for image segmentation. Fractional calculus, which extends the concept of derivatives and integrals to arbitrary orders, effectively addresses non-local hereditary properties images, capturing textures patterns across various scales complexities. TDA, utilizing robust tools identifying shape connectivity features, complements this by intricate characteristics...
<h3>BACKGROUND AND PURPOSE:</h3> Several studies have questioned the traditional belief that corticospinal tract (CST) arises exclusively from precentral gyrus and passes through anterior half of posterior limb internal capsule (PLIC) in humans; however, no direct evidence existed structural imaging, developmental aspects CST origin not been clarified. We used diffusion tensor imaging (DTI) tractography to test hypotheses can originate both pre- postcentral gyri is located posteriorly PLIC,...
This study utilized diffusion tensor imaging fiber tractography to examine the miscrostructural integrity of limbic and paralimbic white matter tracts in 36 children (age M = 124 months) with histories early deprivation, raised from birth orphanages subsequently adopted into United States, compared 16 age-matched typically developing children. We found increased mean diffusivity bilaterally arcuate fasciculus reduced fractional anisotropy uncinate cingulum deprivation. Microstructural left...
Class III β-tubulin plays a prominent role in the development of drug resistance to paclitaxel by allowing incorporation GBP1 GTPase into microtubules. Once cytoskeleton, binds prosurvival kinases such as PIM1 and initiates signaling pathway that induces paclitaxel. Therefore, inhibition GBP1:PIM1 interaction could potentially revert A panel 44 4-azapodophyllotoxin derivatives was screened NCI-60 cell panel. The result is 31 are active comparative analysis demonstrated specific activity...
Summary Objective Cortical resections in epilepsy surgery tend to be larger children, compared adults, partly due underlying pathology. Some children show unilateral multifocal seizure onsets involving much of the hemisphere. If there were a significant hemiparesis present, hemispherectomy would procedure choice. Otherwise, it is preferable spare primary sensorimotor cortex. We report results “subtotal” 23 children. Methods All (ages 1 year and 4 months 14 years 2 months) operated on between...
Purpose: Previously, we reported carboxymethyl cellulose (CMC) binding to human corneal epithelial cells and promoting wound closure in vitro. Using an animal model, the efficacy of CMC healing was examined. Materials Methods: Following wounding NZ white rabbits, (0.2% or 1.0%) control vehicle (PBS) administered topically (4 times daily for 3 days) wounded unwounded eyes with without contact lens wear. Wound response treatments measured as percentage reduction fluorescein-stained area 0 72...
The PET tracer (11)C-(R)-PK11195 (PK) is an antagonist of the peripheral-type benzodiazepine binding site and allows noninvasive imaging microglial activation seen in several neurologic disorders affecting mature developing brain. objective this study was to derive biodistribution vivo radiation dose estimates PK children studied for brain inflammatory conditions healthy adults.Twenty-two (mean age +/- SD, 9.5 4 y; range, 4-17 10 girls) who underwent dynamic involving inflammation were...
<h3>BACKGROUND AND PURPOSE:</h3> One of the neurologic substrates poor language in children with DD is abnormal development perisylvian networks. We sought to determine whether this manifests as aberrant regional changes diffusivity or geometry left AF. <h3>MATERIALS METHODS:</h3> performed DTI studies 16 young (age, 55.4 ± 18.95 months) patients and 11 age- sex-matched TD 60.09 21.27 months). All were right-handed. To detect malformation AF structure native standard space, we proposed new...
This study was performed to evaluate the cerebral protein synthesis rate of language brain regions in children with developmental delay and without pervasive disorder. The authors L-[1-(11)C]-leucine positron emission tomography (PET) on 8 disorder (mean age, 76.25 months) 77.63 months). They found a higher left posterior middle temporal region (P = .014). There significant correlation Gilliam Autism Rating Scale autism index score (r .496, P .05). In addition, asymmetric (right > left)...
Intracavernous papaverine has found an important place in the management of male erectile failure. The effect this mode therapy was studied 48 patients with psychogenic impotence. average follow-up for group ranged from 7 months to 37 (mean 16.3 months). All were advised sex as initial therapy. On refusal undergo therapy, they offered option intracavernous injection. Papaverine appears break performance anxiety failure cycle and noted have good results. Overall 57.9% expressed complete...