A5080981633- Gut microbiota and health
- Probiotics and Fermented Foods
- Genetics, Aging, and Longevity in Model Organisms
- Cellular transport and secretion
- Light effects on plants
- Immune Cell Function and Interaction
- Plant Molecular Biology Research
- Diabetes and associated disorders
- Spaceflight effects on biology
- Digestive system and related health
- Photosynthetic Processes and Mechanisms
- Clostridium difficile and Clostridium perfringens research
- Pleistocene-Era Hominins and Archaeology
- Pancreatic function and diabetes
- Gastrointestinal motility and disorders
- Diabetes Management and Research
- Ginseng Biological Effects and Applications
Rutgers, The State University of New Jersey
2017-2024
Institute of Botany
2024
Chinese Academy of Sciences
2024
University of Chinese Academy of Sciences
2024
Rutgers Sexual and Reproductive Health and Rights
2017-2023
Abstract Light and temperature are 2 major environmental factors that affect the growth development of plants during their life cycle. Plants have evolved complex mechanisms to adapt varying external environments. Here, we show JASMONATE ZIM-domain protein 3 (JAZ3), a jasmonic acid signaling component, acts as factor integrate light in regulating seedling morphogenesis. JAZ3 overexpression transgenic lines display short hypocotyls under red, far-red, blue warm (28 °C) conditions compared...
Gut bacteria generate from dietary tryptophan (trp) indole compounds, which act as potent signaling molecules intricately involved in the regulation of intestinal homeostasis and barrier integrity. Lactobacillus rhamnosus GG (LGG), a widely used probiotic, has demonstrated ability to restore gut animal models colitis sepsis, well children with irritable bowel syndrome. To investigate hypothesis that LGG-derived indoles are responsible for its barrier-enhancing properties, we fed gnotobiotic...
Abstract Insulin is the essential treatment of Type 1 (T1D) and often used in 2 Diabetes. For nearly five decades, efforts have been focused on replenishing β-cells T1D patients as a more durable treatment. Gut endocrine cells can be converted into insulin-producing cells, but their numbers are limited. In this study we report that insulin-immunoreactive with Paneth/goblet cell features present human fetal intestine, addition to enteroendocrine cells. Accordingly, lineage tracing experiments...
Abstract Paneth cells produce antimicrobial proteins such as lysozyme and cytokines to interact with gut microbiota mucosal immune system respectively, maintaining delicate homeostasis. Abnormalities in expression or intracellular distribution have been cataloged patients inflammatory bowel disease (IBD) mouse IBD models. However, it is unclear whether these defects are simply the consequences of pathogenesis they may also contribute progression. To explore role cell a microbe-friendly...
Abstract The naked mole rat (NMR), Heterocephalus glaber , the longest-living rodent 1 provides a unique opportunity to explore how evolution has shaped adult stem cell (ASC) activity with increasing lifespan. Using cumulative BrdU labelling and quantitative imaging approach track intestinal ASCs ( Lgr5 + ) in NMRs over time their native vivo state, we show adaptations living near-anaerobic 2 food-deprived 3 subterranean environment, necessitated an expanded pool of cells, which exhibit...
The small intestine which is characterized by different cell types lining specific sites along the crypt‐villus axis plays a critical role in water, electrolyte and mineral balance. Normally, net fluid absorption occurs mainly because ion‐dependent villus column greater than ion‐driven secretion crypt. To generate these site‐specific ion gradients, appropriate transporters must be strategically located cells crypt or regions. multivalent ions calcium iron also function as essential minerals,...
Although the influence of gut microbiota on structure and proliferation intestinal epithelial cells has been established, there is disconcordance information related to cell type differentiation, because most studies probiotics reflected an outcome from interactions among Lactobacillus, numerous existing microbes, host, with limited insight specific impact Lactobacilli spp. For example, L. reuteri enhanced goblet Paneth differentiation in intestine conventionally-raised chickens established...
The molecular links between tissue-level morphogenesis and the differentiation of cell lineages in pancreas remain elusive despite a decade studies. We previously showed that both these processes depend on proper lumenogenesis. Rab GTPase Rab11 has been shown to be essential epithelial lumen formation vitro, however few studies have addressed its functions vivo none tested requirement pancreas. Here, we show is critical development. Co-deletion isoforms Rab11A Rab11B developing pancreatic...