A5010768947- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Education and Admissions
- Diversity and Career in Medicine
- Air Quality and Health Impacts
- Global Maternal and Child Health
- Poverty, Education, and Child Welfare
- Infant Development and Preterm Care
- Healthcare Policy and Management
- Global Health Care Issues
- Appendicitis Diagnosis and Management
- DNA Repair Mechanisms
- African Sexualities and LGBTQ+ Issues
- Innovations in Medical Education
- Genetic factors in colorectal cancer
- Maternal and Neonatal Healthcare
- Congenital Diaphragmatic Hernia Studies
- Cancer Genomics and Diagnostics
- Health Literacy and Information Accessibility
- Noise Effects and Management
- Childhood Cancer Survivors' Quality of Life
- Reproductive Health and Technologies
- Maternal and Perinatal Health Interventions
- Health disparities and outcomes
- Social Media in Health Education
Children's Hospital of Philadelphia
2023-2025
University of Pennsylvania
2023-2025
Boston Children's Hospital
2021
Boston Medical Center
2020
Princeton University
2012
MSH2 is required for DNA mismatch repair recognition in eukaryotes. Deleterious mutations human account approximately half of the alleles associated with a common hereditary cancer syndrome. Previously, we characterized clinically identified missense mutations, using yeast as model system, and found that most cause defective was low levels variant Msh2 proteins. Here, show increased protein turnover responsible reduced cellular levels. Increasing gene dosage more than fully restored...
This Viewpoint suggests that pediatricians’ contact with the maternal-infant dyad postpartum presents an opportunity to address US maternal mortality crisis and its inequities.
ABSTRACT Background Zika virus (ZIKV)-associated congenital microcephaly is an important contributor to pediatric death, and more robust mortality risk metrics are needed help guide life plans clinical decision making for these patients. Although common etiologies of adult differ, early health can impact outcomes—potentially through DNA methylation. Hence, in this pilot study, we take step identifying by examining associations ZIKV infection associated with existing methylation-based...
Objective: To analyze the association of components Centers for Disease Control and Prevention (CDC) Environmental Justice Index (EJI) with respiratory health outcomes among infants bronchopulmonary dysplasia (BPD) within one year after discharge from neonatal intensive care unit. Methods: This was a retrospective cohort study preterm BPD. Multivariable logistic regression models estimated associations EJI its medically attended acute illness, defined as an ED visit or inpatient readmission,...
Abstract Objectives To quantify the association of ambient air pollution (particulate matter, PM 2.5 ) exposure with medically attended acute respiratory illness among infants bronchopulmonary dysplasia (BPD). Study Design Single center, retrospective cohort study preterm BPD in Metropolitan Philadelphia. Multivariable logistic regression quantified associations annual mean (per μg/m 3 at census block group level illness, defined as emergency department (ED) visits or hospital readmissions...
Preterm birth (defined as <37 weeks of gestation) is a significant health concern globally, with lasting implications for individuals, families, and society. In the United States, high preterm rates among Black low-income populations likely result from differences in environmental exposures. Structural racism economic disadvantage have led to unequal distribution polluting industrial sites roadways across society well differential access health-promoting resources which contribute risk. Once...