A5102027808- RNA modifications and cancer
- Cancer-related gene regulation
- RNA Research and Splicing
- HVDC Systems and Fault Protection
- Gut microbiota and health
- Photodynamic Therapy Research Studies
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Microbial Metabolism and Applications
- Biochemical effects in animals
- Skin Protection and Aging
- Cancer-related Molecular Pathways
- Digestive system and related health
Sun Yat-sen University
2023-2025
University of Massachusetts Chan Medical School
2004
Keio University
2004
Sichuan University
2004
Currently, the influence of tumor microbiome on effectiveness immunotherapy remains largely unknown. Intratumoural Fusobacterium nucleatum (Fn) functions as an oncogenic bacterium and can promote progression in esophageal squamous cell carcinoma (ESCC). Our previous study revealed that Fn is a facultative intracellular its virulence factor Fn-Dps facilitates survival Fn. In this study, we find DNA enriched nonresponder (NR) group among ESCC patients receiving PD-1 inhibitor serum antibody...
The tumor-associated microbiota plays a vital role in cancer development. Accumulating evidence shows that Fusobacterium nucleatum (Fn) participates the progression of multiple tumor types. However, underlying mechanisms remain unclear. This study examined expression methyltransferase-like protein 3 (METTL3) during Fn infection and elucidated function pathway Fn-induced m6A methylation esophageal squamous cell carcinoma (ESCC). abundance patient tissues was determined by qPCR. Western blot,...
Even though increased accumulations of radiolabeled antisense DNAs compared to control are becoming a routine observation in cultured tumor cells, trustworthy evidence targeting vivo by an mechanism remains elusive. The goal this study was obtain convincing nude mice using two different tumors and both intratumoral (i.t.) intravenous (i.v.) administration sense DNAs. Both the MDR++ cell line KB-G2 its parent MDR+ KB-31 were used study. (AS) DNA directed against AUG start codon MDR1 mRNA and,...