A5011794788- Cancer Immunotherapy and Biomarkers
- Clostridium difficile and Clostridium perfringens research
- Streptococcal Infections and Treatments
- Organ Transplantation Techniques and Outcomes
- Cancer, Stress, Anesthesia, and Immune Response
- Ferroptosis and cancer prognosis
- Luminescence Properties of Advanced Materials
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Transplantation: Methods and Outcomes
- Sirtuins and Resveratrol in Medicine
- Photodynamic Therapy Research Studies
- Liver Disease and Transplantation
- Diverse Approaches in Healthcare and Education Studies
- Cancer-related gene regulation
- Natural Compound Pharmacology Studies
- Nerve injury and regeneration
- Gut microbiota and health
- Protease and Inhibitor Mechanisms
Sun Yat-sen University
2018-2025
Xuzhou Medical College
2024
Nantong University
2022
Affiliated Hospital of Nantong University
2022
Mianyang Normal University
2012
Wuhan University of Technology
2009
Affiliated Hospital of North Sichuan Medical College
2006
Disulfiram/copper (DSF/Cu) is a promising antitumor reagent for clinical application due to its excellent anticancer activity and safety. However, the mechanism of DSF/Cu has not been fully elucidated. Our study showed that strongly induced cytotoxic effects on both nasopharyngeal carcinoma (NPC) cells α-smooth muscle actin (α-SMA)-positive fibroblasts. Fluorescence activated cell sorting (FACS) analysis further higher late apoptosis rate in α-SMA-positive fibroblasts than tumor cells,...
Currently, the influence of tumor microbiome on effectiveness immunotherapy remains largely unknown. Intratumoural Fusobacterium nucleatum (Fn) functions as an oncogenic bacterium and can promote progression in esophageal squamous cell carcinoma (ESCC). Our previous study revealed that Fn is a facultative intracellular its virulence factor Fn-Dps facilitates survival Fn. In this study, we find DNA enriched nonresponder (NR) group among ESCC patients receiving PD-1 inhibitor serum antibody...
Fusobacterium nucleatum (Fn) is a critical colorectal cancer (CRC)-associated bacterium. DNA hunger/stationary phase protective proteins (Dps) are bacterial ferritins that protect from oxidative stress. However, little known about the regulatory roles of Fn-Dps towards host cellular functions. Here, we identified culture supernatant Fn by mass spectrometry, and prepared recombinant protein. We show novel virulence protein Fn, Fn-Dps, which lyses disrupts erythrocytes competition for iron...
Methyltransferase-like 3 (METTL3) is an RNA methyltransferase mediating N6 methyladenosine (m6A) modification. Its role in cancer pathogenesis and progression has attracted increasing attention. However, the immunological role, possible immune mechanism, clinical significance of METTL3 esophageal squamous cell carcinoma (ESCC) remain to be confirmed. The Tumor Genome Atlas (TCGA) provided transcriptome sequencing data for this study (162 tumor tissue samples 11 normal samples), while...
The intracellular bacterium Fusobacterium nucleatum (Fn) mediates tumorigenesis and progression in colorectal cancer (CRC). However, the origin of intratumoral Fn role Fn-infected immunocytes tumor microenvironment remain unclear. Here, we observed that neutrophils/macrophages (PMNs/MΦs), especially PMNs, accumulate tissues fecal abundance correlates positively with an blood PD-L1+ PMNs CRC patients. Moreover, accumulates tumor-bearing mice via intragingival infection intravenous injection....
In brief Brown adipose tissue impaired in polycystic ovary syndrome (PCOS) plays a crucial role the treatment of PCOS. This study shows that myricetin potently improves PCOS by activating brown (BAT). Abstract is complex endocrine disease characterized hyperandrogenism, anovulation and ovary, often accompanied metabolic disorder such as insulin resistance. BAT has been considered promising target for obesity other disease. this study, we showed 3 weeks (a compound from natural product)...
Two polyprenylated acylcyclopentanone racemates, evodialones A (1) and B (2), featuring a 3-ethyl-1,1-diisopentyl-4-methylcyclopentane skeleton, were isolated from an extract of the aerial parts Evodia lepta. Evodialone was resolved by chiral-phase HPLC to afford pair enantiomers, (+)- (−)-evodialones (1b/1a), while evodialone (2) could not be resolved. Their structures elucidated spectroscopic analysis combination computational techniques including gauge-independent atomic orbital...
Objective: Nasopharyngeal carcinoma (NPC) is a malignant head and neck tumor that highly prevalent in Southeast Asia. The two traditional NPC markers VCA-IgA (EBV viral capsid antigen) EA-IgA early are limited the screening diagnosis of NPC. purpose present study to evaluate diagnostic value matrix metalloproteinase-3 (MMP3) Methods: levels 23 secretory MMPs serum samples from 15 healthy controls 26 patients were detected by Cytokine Antibody Array 2000. Immunohistochemistry, Real-time PCR...
Spinal cord injury (SCI) is the most severe result of spine injury, but no effective therapy exists to treat SCI. We have previously shown that E3 ubiquitin ligase Two RING fingers and DRIL 1 (Triad1) promotes neurite outgrowth after However, mechanism by which Triad1 affects neuron growth potential involvement its ubiquitination activity unclear. Neuroprotective cytokine pleiotrophin (PTN) can promote microglia proliferation neurotrophic factor secretion achieve neuroprotection. find using...
Background: Fusobacterium nucleatum (Fn) is a critical colorectal cancer (CRC)-associated bacterium. DNA hunger/stationary phase protective proteins (Dps) are bacterial ferritins that protect from oxidative stress. However, little known regarding the host cell responses to Dps.Methods: Fn-Dps was identified culture supernatant of Fn by mass spectrometry. The pET28a-Fn-Dps plasmid constructed prepare recombinant protein. In vitro effect on erythrocytes determined count with hemocytometer....