A5068605356- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Rheumatoid Arthritis Research and Therapies
- Acute Myeloid Leukemia Research
- Systemic Lupus Erythematosus Research
- Advanced Breast Cancer Therapies
- Cancer Cells and Metastasis
- Autoimmune and Inflammatory Disorders Research
- Ocular Diseases and Behçet’s Syndrome
- Inflammasome and immune disorders
- Cancer-related Molecular Pathways
- Head and Neck Cancer Studies
- Epigenetics and DNA Methylation
- Connective tissue disorders research
- Cancer Treatment and Pharmacology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Tissue Engineering and Regenerative Medicine
- Brain Metastases and Treatment
- Cytokine Signaling Pathways and Interactions
- TGF-β signaling in diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cancer Diagnosis and Treatment
- Bone fractures and treatments
- Lung Cancer Research Studies
Université Paris Sciences et Lettres
2020-2023
Institut Curie
2020-2023
Inserm
2009-2020
Zimmer Biomet (France)
2020
Université Paris Cité
2009-2020
Centre National de la Recherche Scientifique
2008-2020
Institut Cochin
2009-2020
Université de Versailles Saint-Quentin-en-Yvelines
2015
Délégation Paris 5
2011-2014
Sorbonne Paris Cité
2014
The choice between chemotherapy and endocrine therapy as first-line treatment for hormone receptor-positive, ERBB2 (also known HER2)-negative metastatic breast cancer is usually based on the presence of clinical features associated with a poor prognosis. In this setting, high circulating tumor cell (CTC) count (≥5 CTCs/7.5 mL) strong adverse prognostic factor overall survival progression-free (PFS).To compare efficacy clinician-driven vs CTC-driven treatment.In CTC arm, patients received or...
Abstract Background Patients with HER2-positive breast cancer (HER2 + BC) develop central nervous system metastases twice as often patients luminal HER2-negative cancer. Leptomeningeal progression results in a drastically altered prognosis limited therapeutic options. This phase II study was conducted to assess the efficacy of intrathecal (IT) trastuzumab HER2 BC leptomeningeal metastasis (LM), based on I dose-escalation that had determined recommended weekly dose 150 mg for II. Methods...
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary point, may be published when key planned co-primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported. In patients with hormone receptor–positive, human epidermal growth factor receptor 2–negative advanced breast...
Several polymorphisms in ERAP1 are strongly associated with susceptibility to spondyloarthritis (SpA). The combination of rs17482078, rs10050860, and rs30187 results the construction 3 major haplotypes that SpA (the "protective" haplotype T/T/C, "neutral" C/C/C, "susceptibility" C/C/T). aim present study was determine whether such might affect endoplasmic reticulum aminopeptidase 1 (ERAP-1) messenger RNA (mRNA) expression, protein level, and/or enzymatic activity antigen-presenting cells, a...
Spondyloarthritis (SpA) is a chronic inflammatory disorder with strong genetic predisposition dominated by the role of HLA-B27. However, contribution other genes to disease susceptibility has been clearly demonstrated. We previously reported significant evidence linkage SpA chromosome 9q31–34. The current study aimed characterize this locus, named SPA2. First, we performed fine mapping SPA2 (24 cM) 28 microsatellite markers in 149 multiplex families, which allowed us reduce area...
<h3>Objective</h3> Spondyloarthritis is a group of articular disorders sharing genetic background. Polymorphisms in the IL-1 gene cluster have previously been associated with ankylosing spondylitis (AS), subset spondyloarthritis. This study examined association between several these polymorphisms and whole Particular attention was devoted to genotype–phenotype correlations. <h3>Methods</h3> Seven single-nucleotide (SNP) variable number tandem repeat located were genotyped 185 independent...
<h3>Objective</h3> A robust association between polymorphisms in the non-major histocompatibility complex gene <i>ERAP1</i> and ankylosing spondylitis (AS) several populations was recently identified. The aim of current study to determine level with spondyloarthritis (SpA) French/Belgian particular attention genotype–phenotype correlations. <h3>Methods</h3> We studied 734 independent SpA cases 632 controls from two European cohorts. Five single-nucleotide (SNPs), rs27044, rs17482078,...
Spondyloarthritis (SpA) is a group of inflammatory articular disorders sharing genetic background. The nonsynonymous single-nucleotide polymorphism (SNP) rs11209026 (Arg381Gln) in the IL23R gene has reproducibly been shown to be associated with ankylosing spondylitis (AS). We undertook this study examine association between and SpA as whole, particular attention devoted genotype/phenotype correlation.The SNP was genotyped French cohort 415 patients/372 controls, replication analysis...
The CXXC5 gene encodes a transcriptional activator with zinc-finger domain, and high expression in human acute myeloid leukemia (AML) cells is associated adverse prognosis. We now characterized the biological context of primary AML cells. global profile derived from 48 consecutive patients was analyzed; low then showed major differences regard to extracellular communication intracellular signaling. observed significant phosphorylation status several signaling mediators (CREB, PDK1, SRC,...
Our group previously identified a new susceptibility region linked to spondylarthritis (SpA) on chromosome 9q31-34. Fine mapping of this SPA2 locus allowed us refine the peak linkage 1.3-Mb interval. The objective study was resequence most positional candidate genes lying in that region, identify polymorphisms, and examine their association with SpA.Variants screening performed 30 independent patients SpA from families high score control subjects. coding regions, intron-exon boundaries, 5'-...
The gene CXXC5, encoding a Retinoid-Inducible Nuclear Factor (RINF), is located within region at 5q31.2 commonly deleted in myelodysplastic syndrome (MDS) and adult acute myeloid leukemia (AML). RINF may act as an epigenetic regulator has been proposed tumor suppressor hematopoietic malignancies. However, functional studies normal hematopoiesis are lacking, its mechanism of action unknow. Here, we evaluated the consequences silencing on cytokineinduced erythroid differentiation human primary...