A5063712283- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Breast Lesions and Carcinomas
- Cancer Immunotherapy and Biomarkers
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Multiple and Secondary Primary Cancers
- Cancer survivorship and care
- Cancer Genomics and Diagnostics
- Uterine Myomas and Treatments
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Renal cell carcinoma treatment
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Sexual function and dysfunction studies
- Genital Health and Disease
- Gynecological conditions and treatments
- Cancer-related molecular mechanisms research
- Breast Implant and Reconstruction
Institut Curie
2016-2025
Inserm
2014-2024
Université Paris Sciences et Lettres
2018-2024
Université Paris-Saclay
2019-2022
Centre hospitalier régional d'Orléans
2005-2022
Université de Versailles Saint-Quentin-en-Yvelines
2015-2022
Hôpital René Huguenin
2016-2021
La Ligue Contre le Cancer
2018-2020
Sorbonne Université
2010-2018
Assistance Publique – Hôpitaux de Paris
2011-2018
A subset of cancer-associated fibroblasts (FAP+/CAF-S1) mediates immunosuppression in breast cancers, but its heterogeneity and impact on immunotherapy response remain unknown. Here, we identify 8 CAF-S1 clusters by analyzing more than 19,000 single from cancer. We validate the five most abundant flow cytometry silico analyses other cancer types, highlighting their relevance. Myofibroblasts 0 3, characterized extracellular matrix proteins TGFβ signaling, respectively, are indicative primary...
Although fibroblast heterogeneity is recognized in primary tumors, both its characterization and impact on metastases remain unknown. Here, combining flow cytometry, immunohistochemistry RNA-sequencing breast cancer samples, we identify four Cancer-Associated Fibroblast (CAF) subpopulations metastatic lymph nodes (LN). Two myofibroblastic subsets, CAF-S1 CAF-S4, accumulate LN correlate with cell invasion. By developing functional assays cultures, demonstrate that these subsets promote...
Abstract High-grade serous ovarian cancers (HGSOC) have been subdivided into molecular subtypes. The mesenchymal HGSOC subgroup, defined by stromal-related gene signatures, is invariably associated with poor patient survival. We demonstrate that stroma exerts a key function in HGSOC. highlight stromal heterogeneity identifying four subsets of carcinoma-associated fibroblasts (CAF-S1-4). Mesenchymal show high content CAF-S1 fibroblasts, which exhibit immunosuppressive functions increasing...
High-grade serous ovarian cancer (HGSOC) remains an unmet medical challenge. Here, we unravel unanticipated metabolic heterogeneity in HGSOC. By combining proteomic, metabolomic, and bioergenetic analyses, identify two molecular subgroups, low- high-OXPHOS. While low-OXPHOS exhibit a glycolytic metabolism, high-OXPHOS HGSOCs rely on oxidative phosphorylation, supported by glutamine fatty acid oxidation, show chronic stress. We important role for the PML-PGC-1α axis features of In tumors,...
Abstract Purpose: Almost all cervical cancers are caused by human papillomavirus (HPV) and patients with advanced stage at high risk for relapse. Circulating HPV DNA (HPV ctDNA) may serve as a residual tumor marker the end of chemoradiation or to predict relapse during follow-up period. Experimental Design: We analyzed serum samples from 94 HPV16- HPV18-related CCs BioRAIDs prospective cohort. Samples were collected before after treatment an 18-month Using digital droplet PCR (ddPCR), we...
Abstract Background Patients with HER2-positive breast cancer (HER2 + BC) develop central nervous system metastases twice as often patients luminal HER2-negative cancer. Leptomeningeal progression results in a drastically altered prognosis limited therapeutic options. This phase II study was conducted to assess the efficacy of intrathecal (IT) trastuzumab HER2 BC leptomeningeal metastasis (LM), based on I dose-escalation that had determined recommended weekly dose 150 mg for II. Methods...
Abstract Although cancer-associated fibroblast (CAF) heterogeneity is well-established, the impact of chemotherapy on CAF populations remains poorly understood. Here we address this question in high-grade serous ovarian cancer (HGSOC), which previously identified 4 populations. While global content stroma increases HGSOC after chemotherapy, proportion FAP + (also called CAF-S1) decreases. Still, maintenance high residual CAF-S1 associated with reduced CD8 T lymphocyte density and poor...
Background Neoadjuvant chemoimmunotherapy (NACI) has significantly increased the rate of pathologic complete response (pCR) in patients with early-stage triple-negative breast cancer (TNBC), although predictors to this regimen have not been identified. Purpose To investigate pretreatment perfusion MRI–based radiomics as a predictive marker for pCR TNBC undergoing NACI. Materials and Methods This prospective study enrolled women who underwent NACI at two different centers from August 2021...
Early luminal breast cancer (BC) represents 70% of newly diagnosed BC cases. Among them, small (under 2 cm) without lymph node metastasis (classified as T1N0) have been rarely studied, their prognosis is generally favorable. Nevertheless, up to 5% T1N0 patients relapse with distant metastases that ultimately prove fatal. The aim our work was identify the mechanisms involved in metastatic recurrence these patients.Our study addresses role autonomous and non-autonomous tumor cell features play...
Chemoradiotherapy (CRT) is the standard of care for patients diagnosed with locally advanced cervical cancer (LACC), a human papillomavirus (HPV)-related that relapses in 30%-60% patients. This study aimed to (i) design HPV droplet digital PCR (ddPCR) assays blood detection (including rare genotypes) and (ii) monitor circulating tumor DNA (HPV ctDNA) levels during CRT LACC.We analyzed samples from 55 HPV-positive LACC treated by retrospective cohort (n = 41) prospective 14). HPV-ctDNA was...
Pathological complete response (pCR) after neoadjuvant chemoimmunotherapy (NACi) is associated with improved patient outcomes in early triple-negative breast cancer (TNBC). This study aimed to identify factors pCR NACi. cohort included all patients stage II-III TNBC treated NACi who underwent surgery at Institut Curie hospitals between 08/2021-06/2023. Among 208 patients, the overall rate was 70% and similar ER < 1% (69%) ER-low (73%, p = 0.6). In a multivariate model, Ki-67 ≥ 30% (OR 5.19...
To evaluate ultrasonography and magnetic resonance imaging (MRI) performance in differentiating benign leiomyomas from malignant mesenchymal or mixed tumors (MMT) smooth muscle of uncertain potential the uterus (STUMP).Retrospective cohort study.University hospital, France.One hundred eight women who underwent before surgery for uterine tumor (85 with 23 MMT/STUMP).The reports were reviewed. Conventional, perfusion diffusion MRI blindly analyzed. Recursive partitioning analysis (RPA) was...