A5004986040- Advanced Radiotherapy Techniques
- Ocular Oncology and Treatments
- Virus-based gene therapy research
- Effects of Radiation Exposure
- RNA Research and Splicing
- interferon and immune responses
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- RNA Interference and Gene Delivery
- Stochastic processes and financial applications
- Lung Cancer Research Studies
- Cancer Research and Treatments
- Oral health in cancer treatment
- Advanced Control Systems Optimization
- Risk and Portfolio Optimization
- Ear and Head Tumors
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Hearing, Cochlea, Tinnitus, Genetics
- Head and Neck Surgical Oncology
- Digital Radiography and Breast Imaging
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
Huazhong University of Science and Technology
2024
Shanghai Jiao Tong University
2003-2021
Renji Hospital
2015-2021
Prenatal lethality associated with mouse knockout of Mettl16, a recently identified RNA N6-methyladenosine (m
Uveal melanoma (UM) is an intraocular malignant tumor in adults that characterized by rapid progression and recurrence. Irradiation has become the primary therapy for UM patients who are not candidates surgery. However, after large-dose fraction irradiation treatment, some undergo subsequent enucleation because of radiotherapy-related complications. This situation raised concerns on how to optimize effectiveness radiation treatment. Recent investigations microRNAs changing our understanding...
Summary Uveal melanoma (UM) is one of the most therapy‐resistant cancers. Radiotherapy preferred treatment for cases UM. However, some UM cells, such as SP6.5 or OM431 cell lines, are relatively radioresistant. In this study, we attempted to improve current therapy using an adenovirus radio‐inducible gene system. The antitumor was constructed by inclusion radiation‐inducible early growth response 1 ( EGR1 ) promoter and anticancer tumor necrosis factor‐related apoptosis‐inducing ligand...
The p53 tumor suppressor pathway is impaired in more than 90% of cervical cancers and cancer-derived cell lines as a result infection by human papillomavirus (HPV). HPV E6 oncoprotein forms complexes with promotes its degradation via ubiquitin-dependent mechanism. In our study, we attempted to improve the clinical outcomes this combined therapy modifying p53-targeted adenovirus become radiation-responsive. antitumor was constructed inserting radiation-responsive expression cassette composed...
Background: Alternative splicing is essential for the physiological and pathological development of inner ear. Disruptions in this process can result both syndromic non-syndromic forms hearing loss. DHX38, a DEAH box RNA helicase, integral to pre-mRNA regulation plays critical roles development, cell differentiation, stem maintenance. However, its specific role ear remains undefined. Here, we utilized dhx38 knockout zebrafish model monitor morphology elucidate crucial DHX38 Methods:...
Objective To analyze the relationship between planning factors of intensity-modulated radiation therapy (IMRT) and gamma index investigate effect each parameter upon γ passing rate IMRT. Methods Gamma analysis was performed using 3%/3 mm acceptance criteria for 457 IMRT beams with different factors. During multi-factor ANOVA rate, control variables primarily included minimum segment area, number monitor unit (MU), segment, conversation, spatial resolution in measured dose...
Abstract Background: Single photon emission computed tomography (SPECT) images provides functional information in both diagnosis and radiation therapy. This study aimed to evaluate a unified framework of different approaches find the optimal one integrating SPECT lung perfusion imaging into radiotherapy estimate pneumonitis. Methods: Twenty-five patients with thoracic tumors were included this study. All had before radiotherapeutic treatment. The registered planning (CT) via rigid-body...
The optimal control problem for partially observable stochastic system is considered. dynamics has the linear affine form and explicit output feedback law this under risk-sensitive cost derived by means of change probability 'complete squares'. This enables one to convert problems into equivalent complete use usual ways solve them.
Radiotherapy at the temporomandibular joint (TMJ) area often results in trismus, however, post radiation ankylosis is extremely rare and has not been previously reported literature. Radiation known to impact vasculature of bony structures leading bone necrosis with certain risk factors including surgical intervention, even teeth extraction, that could lead osteoradionecrosis. Accordingly, gap arthroplasty for such case seemed rather challenging. In this report, we introduce first time, a...