A5032534616- Pressure Ulcer Prevention and Management
- Mental Health Treatment and Access
- Immunotherapy and Immune Responses
- COVID-19 Digital Contact Tracing
- Immune cells in cancer
- Wound Healing and Treatments
- Salivary Gland Disorders and Functions
- Privacy, Security, and Data Protection
- Radiation Dose and Imaging
- Immune Cell Function and Interaction
- Radiology practices and education
- Single-cell and spatial transcriptomics
- Osteoarthritis Treatment and Mechanisms
- Empathy and Medical Education
- Healthcare Systems and Challenges
- Medical Education and Admissions
- Vitamin C and Antioxidants Research
- International Development and Aid
- Global Security and Public Health
- Educational Games and Gamification
- Atrial Fibrillation Management and Outcomes
- Mental Health and Psychiatry
- Genetic Associations and Epidemiology
- Influenza Virus Research Studies
- Pharmaceutical Quality and Counterfeiting
University of Michigan
2025
Imperial College London
2022-2024
National Institute of Dental and Craniofacial Research
2023-2024
National Institutes of Health
2023-2024
Mersey Care NHS Trust
2023
Chelsea and Westminster Hospital
2022
St. Michael's Hospital
2022
University of Alabama at Birmingham
2020-2021
Swansea University
2021
Shaheed Zulfiqar Ali Bhutto Institute of Science and Technology
2021
Objective: To investigate gut microbiota and intestinal barrier function changes after orthopedic surgery in elderly patients with either normal cognition (NC) or a prodromal Alzheimer disease phenotype (pAD) comprising subjective cognitive decline (SCD) amnestic mild impairment (aMCI). Background: Homeostatic disturbances induced by surgical trauma and/or stress can potentially alter the before surgery. Methods: In this prospective cohort study, 135 were subject to preoperative...
Osteoarthritis (OA) is a multifactorial disease leading to degeneration of articular cartilage, causing morbidity in approximately 8.5 million the UK population. As dense extracellular matrix cartilage primarily composed collagen, repair strategies have exploited biocompatibility and mechanical strength bovine porcine collagen produce robust scaffolds for procedures such as matrix-induced chondrocyte implantation (MACI). However, mammalian sourced collagens pose safety risks spongiform...
Sjögren's Disease (SjD) is a systemic autoimmune disease without clear etiology or effective therapy. Utilizing unbiased single-cell and spatial transcriptomics to analyze human minor salivary glands in health we developed comprehensive understanding of the cellular landscape healthy how that changes SjD patients. We identified novel seromucous acinar cell types population
Long-standing hypertension (HTN) affects multiple organs and leads to pathologic arterial remodeling, which is driven by smooth muscle cell (SMC) plasticity. To identify relevant genes regulating SMC function in HTN, we considered Genome Wide Association Studies (GWAS) of blood pressure, focusing on encoding epigenetic enzymes, control fate cardiovascular disease. Using statistical fine mapping the KDM6 (JMJD3) locus, found that rs62059712 most likely casual variant, with each major T allele...
Digital games are increasingly used to support learning across a diverse range of cognitive, affective and psychomotor domains in health professions education. Game-based will likely become an important competency for educators. However, educators can perceive game building as out their reach due lack expertise digital technology. This toolbox offers advice who would like build simple known educational escape room.
We estimated the impact on US export economy of an illustrative infectious disease outbreak scenario in Southeast Asia that has 3 stages starting 1 country and, if uncontained, spreads to 9 countries. used 2014-2016 West Africa Ebola epidemic–related World Bank estimates 3.3% and 16.1% reductions gross domestic product (GDP). also Department Commerce job data calculate export-related jobs at risk any outbreak-related disruption exports. Assuming a direct correlation between GDP reduced...
<title>Abstract</title> Sjögren's Disease (SjD) is a systemic autoimmune disease without clear etiology or effective therapy. Utilizing unbiased single-cell and spatial transcriptomics to analyze human minor salivary glands in health we developed comprehensive understanding of the cellular landscape healthy how that changes SjD patients. We identified novel seromucous acinar cell types population <italic>PRR4+CST3+WFDC2-</italic>seromucous cells are particularly targeted SjD. Notably,...
In October 2009, the first case of pandemic influenza A(H1N1)pdm09 (pH1N1) was confirmed in Kigali, Rwanda and countrywide dissemination occurred within several weeks. We describe clinical epidemiological characteristics this epidemic.From 2009 through May 2010, we undertook epidemiologic investigations response to pH1N1. Respiratory specimens were collected from all patients meeting WHO definition for pH1N1, which tested using CDC's real time RT-PCR protocol at Rwandan National Reference...
To reduce the health security risk and impact of outbreaks around world, US Centers for Disease Control Prevention its partners are building capabilities to prevent, detect, contain in 49 global priority countries. We examine extent economic vulnerability export economy posed by trade disruptions these Using 2015 Department Commerce data, we assessed value exports number jobs supported those exports. countries exceeded $308 billion more than 1.6 million across all states agriculture,...
<p dir="ltr"><b>Abstract</b></p><p dir="ltr">Macrophage (Mφ) plasticity is critical for normal wound repair; however, in type 2 diabetic wounds, Mφs persist a low-grade inflammatory state that prevents the resolution of inflammation. Increased NLRP3 inflammasome activity has been shown Mφs; molecular mechanisms regulating expression and are unclear. Here, we identified keratinocytes induce <i>Nlrp3 </i>gene through IL-1 receptor-mediated signaling,...
<p dir="ltr"><b>Abstract</b></p><p dir="ltr">Macrophage (Mφ) plasticity is critical for normal wound repair; however, in type 2 diabetic wounds, Mφs persist a low-grade inflammatory state that prevents the resolution of inflammation. Increased NLRP3 inflammasome activity has been shown Mφs; molecular mechanisms regulating expression and are unclear. Here, we identified keratinocytes induce <i>Nlrp3 </i>gene through IL-1 receptor-mediated signaling,...
Abstract Long-standing hypertension (HTN) affects multiple organ systems and leads to pathologic arterial remodeling, which is driven largely by smooth muscle cell (SMC) plasticity. Although genome wide association studies (GWAS) have identified numerous variants associated with changes in blood pressure humans, only a small percentage of these actually cause HTN. In order identify relevant genes important SMC function HTN, we screened three separate human GWAS Mendelian randomization SNPs...
Background The NHS (National Health Service) COVID-19 app was a digital contact tracing (DCTA) used in England response to the pandemic. aim of which limit spread by providing exposure alerts. At time pandemic, questions were raised regarding effectiveness and cost whether DCTAs have role future pandemics. Objective This study aims explore key barriers during Methods is qualitative using semistructured video interviews conducted with professionals public health, clinicians, health care law,...
<sec> <title>BACKGROUND</title> The NHS (National Health Service) COVID-19 app was a digital contact tracing (DCTA) used in England response to the pandemic. aim of which limit spread by providing exposure alerts. At time pandemic, questions were raised regarding effectiveness and cost whether DCTAs have role future pandemics. </sec> <title>OBJECTIVE</title> This study aims explore key barriers during <title>METHODS</title> is qualitative using semistructured video interviews conducted with...
Objective To analyze the incidence, predictors, and cost of 30-day left atrial appendage closure readmissions utilizing Nationwide Readmissions Database (NRD) to develop a scoring system predict readmission risk. Background Determining incidence predictors post-left can direct resources towards high-risk patients. Methods International Classification Diseases, Tenth Revision (ICD-10) codes were used identify We excluded patients who discharged or died in December 2016. Influential factors...
Background: Consultation-liaison (C-L) psychiatry is the subspecialty of dealing with mental health disorders in nonpsychiatric settings. The ubiquity problems has increased need for such a service to exist general hospital psychiatric units, as many patients report different specialty medicine first time. This study aims evaluate utilization C-L services by inpatient units unit taking into consideration paucity data understanding trends and improving provision future. Materials Methods: A...
reflections from four medical students Life & Times 'Are you sure can handle it?''You're quite bossy, you'd fit right in.' 'When will have time for kids?' 'Oh, your partner wants to become a surgeon?Great news you!' 'Nurse, get the doctor me?' 'It's good you're making sacrifice general practitioner nowmeans more family!'
This paper researches the way in which marriage as a concept has evolved Pakistani culture. individuals are studied and researched within Pakistan, well outside foreign countries. The customary arranged situation is studied, its effects on life of both husband wife. We also look at evolution how change brought love marriages or have begun to arise effect culture connection violence been studied. Ultimately, regarding evolving over time future, we hope see even more includes an acceptance for...
Background: The Hospital Readmission Reduction Program (HRRP) sought to reduce readmissions by penalising centres with above the national average, and heart failure (HF) is leading driver of readmission penalty. Recent Medicare analyses question effectiveness this strategy. This study evaluated efficacy HRRP utilising large datasets first analyse based on subtypes. Methods: Aggregate data was used from National Inpatient Sample (NIS) mortality Readmissions Database (NRD) readmissions. Both...