Ibuprofen was the first member of Propionic acid derivatives introduced in 1969. It is a popular domestic and over counter analgesic antipyretic for adults children. has been rated as safest conventional NSAID by spontaneous adverse drug reaction reporting systems UK. This article summarizes main pharmacological effects, therapeutical applications reactions, drug-drug interactions food ibuprofen that have reported especially during last 10 years.

The effect of drug on a person may be different than expected because that interacts with another the is taking (drug-drug interaction), food, beverages, dietary supplements consuming (drug-nutrient/food interaction) or disease has (drug-disease interaction). A interaction situation in which substance affects activity drug, i.e. effects are increased decreased, they produce new neither produces its own. These interactions occur out accidental misuse due to lack knowledge about active...

Natural polymers have been extensively utilized in the past decades due to their outstanding features. Among these natural excipients, protein‐based superb features owing high drug binding capacity and biodegradability. Whey protein is a versatile vehicle for delivery systems. It has shown be nontoxic, biocompatible, biodegradable. Therefore, it considered as an ideal biomaterial design of advanced Protein‐based cargo acts synthetic counterpart innovative The current review mainly focused on...

Drug use has been identified as a major public issue in Pakistan. A descriptive questionnaire survey Karachi city was made to identify the socioeconomic profile and beliefs practices of 500 drug users The most commonly used drugs were cocaine (19.0%) crack-cocaine (15.0%), followed by amphetamine, (11.0%), alcohol, caffeine, barbiturates benzodiazepines (10.0% each). Key psychological factors leading tc problems with parental or marital relations break-up relationship (45.0%). Drugs seer an...

Objectives: This study was planned to determine the extent which role of a pharmacists is established in community pharmacies Pakistan and need qualified experienced provision healthcare at these medical stores or so called pharmacies. Materials Methods: A structured questionnaire distributed random sample 175 attendants various located different areas Karachi with response rate 90.28%. Questionnaire consisted 24 closed ended questions whose consistency reliability were determined by...

It constitutes a substantial proportion of the global burden disease. Major depressive disorder (MDD) was identified by World Health Organization (WHO) in 2001 as fourth leading cause disability and premature death world. is estimated that year 2020 MDD would be second to ischemic heart disease regard burden.

Ibuprofen is a propionic acid derivative that belongs to the class NSAIDs. Major adverse reactions associated with are related GIT and include peptic mucosal ulcers, dyspepsia, severe gastric pain bleeding, results in excessive treatment failure. The goal of this study was develop enteric coated ibuprofen tablets order avoid irritation, diffusion drug across lining let active ingredient be absorbed easily small intestine. formulation developed manufactured through direct compression process,...

Limited knowledge exists regarding the diversity of mangrove plant-associated Pseudarthrobacter species. This study presents first draft genome and phylogenetic analysis a oxydans NCCP-2145, isolated from rhizospheric soil Aviciana marina, native plant found in Miani Hor, Lasbela-Baluchistan, Pakistan. The P. NCCP-2145 comprises 4,495,869 base pairs, with G+C content 65.9% 4,207 coding sequences. Genome annotation revealed presence multiple biosynthesis pathways. also identified genes...

This quantitative study aimed to explore the impact of dysfunctional parenting on aggression and disruptive behaviour among children. The data were collected from 100 children studying at different institutes in Rawalpindi, using a purposive sampling technique. participants varied age between 11-14 years. Three scales, that is, Parenting Scale (PS), Aggression (AS), Disruptive Behaviour Sale Professed by Students (DBS-PS) used for collection. analysis was performed correlation analysis,...

To assess the risk factors, frequency and transience rate for ventilator-associated pneumonia in geriatric patients.Cross-sectional, descriptive study.Various campuses of Ziauddin University Hospital Civil Hospital, Karachi, from April 2016 to May 2017.Critically ill patients (aged 60 years above) intensive care units, were selected who had received mechanical ventilation. Various microbial fate, related clinical outcomes measured cohort 350 patients.It was found that 72% (n=252) study...

Nerium oleander (L.) is well known traditionally used medicinal plant with several pharmacological activities. However, the anti-bacterial, anti-inflammatory activity and in vivo toxicity potential of floral parts this are not reported. Therefore present study was designed to investigate these activities ethanolic flower extract (NOEE) different animal models.Antimicrobial compared five antibiotics using disk diffusion method. The time-killing kinetic assay bacterial killing mechanism NOEE...