A5101798997- Drug Solubulity and Delivery Systems
- Protein purification and stability
- Osteoarthritis Treatment and Mechanisms
- Spine and Intervertebral Disc Pathology
- Crystallization and Solubility Studies
- Silk-based biomaterials and applications
- Musculoskeletal pain and rehabilitation
- Granular flow and fluidized beds
- Powder Metallurgy Techniques and Materials
- Electrospun Nanofibers in Biomedical Applications
- Microencapsulation and Drying Processes
- Analytical Chemistry and Chromatography
- Diet and metabolism studies
- Knee injuries and reconstruction techniques
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Animal Nutrition and Physiology
- Liver Disease and Transplantation
- Telomeres, Telomerase, and Senescence
- Advanced Drug Delivery Systems
- Auditing, Earnings Management, Governance
- Phytochemical Studies and Bioactivities
- bioluminescence and chemiluminescence research
- Injection Molding Process and Properties
- Meat and Animal Product Quality
Ashland (United States)
2020-2025
Wenzhou Medical University
2023-2024
Air Force General Hospital PLA
2023-2024
China Medical University
2023-2024
Hainan University
2023-2024
Chongqing University
2022
Jinzhou Medical University
2022
Guilin Medical University
2022
United States Military Academy
2016-2020
Abstract Metabolic-associated fatty liver disease (MAFLD) is related to metabolic dysfunction and characterized by excess fat storage in the liver. Several studies have indicated that glutamine could be closely associated with lipid metabolism disturbances because of its important role intermediary metabolism. However, effect supplementation on MAFLD progression remains unclear. Here, we used a high-fat diet (HFD)-induced C57BL/6 mouse model, was supplied drinking water at different time...
The production of amorphous solid dispersions via hot melt extrusion (HME) relies on elevated temperature and prolonged residence time, which can result in potential degradation decomposition thermally sensitive components. Herein, the rheological properties a physical mixture polymer an active pharmaceutical ingredient (API) were utilized to guide selection appropriate HME processing temperature. In currently studied copovidone–nifedipine system, critical temperature, is substantially lower...
In this study, a three-dimensional composite scaffold with piezoelectric stimulation and synergistic bioactive factors was developed for promoting cartilage repair. Good results were observed in both vitro vivo repair experiments.
Abstract Sepsis‐induced cardiomyopathy is a decisive factor that plays critical role in the high mortality of septic patients critically ill. Mitochondrial dysfunction occurring during sepsis vital contributor to pathogenesis myocardial damage. Rosmarinic acid (RA), natural poly‐phenolic compound, has showed cardio‐protective and mitochondrial protective effect. The present study was aimed investigate effect RA on sepsis‐induced cardiomyopathy. Adult mice were subjected intraperitoneal...
Dioscorea alata L. anthocyanins (DAC) are natural compounds found in plants and have shown potential health benefits. The objective of this investigation was to assess the impact sourced from on growth, carcass traits, antioxidant potential, immune response Hainan black goats. In study, 30 three-month-old goats (with a weight 11.30 ± 0.82 kg) were selected randomly divided into two groups, with 15 each group. During 60-day experiment, control group (CON) treatment were, respectively,...
Epidemiological studies investigating the association between carnitine and breast cancer are scarce.This 1:1 age-matched retrospective case-control study identified 991 female cases controls without using pathological testing. We used targeted metabolomics technology to measure 16 types of whole blood compounds, such as free (C0) octadecanoylcarnitine (C18).The average age for was approximately 50 ± 8.7 years. After adjusting covariates, each standard deviation (SD) increase in...
Background Surgically treated anterior cruciate ligament (ACL) injuries may be a waivable condition and allow return to full flight status, but waivers are based on expert opinion rather than recent published data. The purpose of this study was evaluate after reconstruction (ACLR) in male military aircrews with ACL identify factors that affect clearance. Method A single-center retrospective review conducted by the authors for all active-duty aircrew who underwent ACLR at an authorized...
Pulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK1A) a pleiotropic involved in regulation multiple biological functions, including cell survival. However, role underlying mechanisms DYRK1A PAH pathogenesis remain unclear. We found that was upregulated PASMCs response to hypoxia, both vivo vitro....
The purple tubers of Dioscorea alata L. have been found to contain a variety bioactive chemical components, including anthocyanins, which make it significant investigate the pre-protective effects and its crude extracts on cells prior oxidative stress. To establish suitable damage model, an injured model IPEC-J2 was created using H2O2 as oxidant. Specifically, when concentration 120 μmol/L time 8 h, survival rate decreased approximately 70%, exhibited noticeable stress reaction. Moreover,...
Background Neck pain (NP) is a common musculoskeletal disorder among fighter pilots and has become rising concern due to its detrimental impact on military combat effectiveness. The occurrence of NP influenced by variety factors, but less attention been paid the association with demographic, occupational, cervical sagittal characteristics in this group. This study aimed investigate prevalence risk factors Chinese male using questionnaire measurements. Methods Demographic flight-related data,...
Objective: Electrospun nanofibers exhibit potential as scaffolds for articular cartilage tissue regeneration. This study aimed to fabricate electrospun polycaprolactone (PCL)/silk fibroin (SF) composite nanofiber and explore performance of the chondrocyte Methods: By altering material composition preparation methods, three types were effectively fabricated, including randomly oriented PCL (RPCL) scaffold, PCL/SF (RPCL/SF) aligned (APCL/SF) scaffold. Physiochemical analyses performed...
High-molecular-weight hypromellose (HPMC) and hydroxypropyl cellulose (HPC) are widely known, extended-release polymers. Conventional high-molecular-weight HPMCs preferred in applications but not used twin-screw melt granulation due to processability difficulties at low operating temperatures potential drug degradation if high processing used. Conversely, grade HPC (Klucel®) can be processes. The purpose of this study was evaluate the dissolution behavior GXF ((Klucel® GXF) a recently...
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