A5103211625- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Hepatitis C virus research
- Cerebrospinal fluid and hydrocephalus
- Organ Donation and Transplantation
- Advances in Oncology and Radiotherapy
- Renal and Vascular Pathologies
- Radiation Detection and Scintillator Technologies
- Atomic and Subatomic Physics Research
- Animal Virus Infections Studies
- Hepatitis B Virus Studies
- Influenza Virus Research Studies
- Analytical Chemistry and Sensors
- Intracranial Aneurysms: Treatment and Complications
- Management of metastatic bone disease
- Lung Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Immune cells in cancer
- Prostate Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Extracellular vesicles in disease
- Pelvic floor disorders treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Single-cell and spatial transcriptomics
University Hospital Heidelberg
2023-2025
Heidelberg University
2023-2025
Heidelberger Institut für Radioonkologie
2024-2025
University Medical Center of the Johannes Gutenberg University Mainz
2008-2012
Johannes Gutenberg University Mainz
2008-2012
Burnet Institute
2009-2012
Abstract Objective: This study investigates the effects of various training protocols on enhancing precision MRI-only Pseudo-CT generation for radiation treatment planning and adaptation in head & neck cancer patients. It specifically tackles challenge differentiating bone from air, a limitation that frequently results substantial deviations representation bony structures images. Approach: The included 25 patients, utilizing pre-treatment MRI-CT image pairs. Five cases were randomly...
This work presents an experimental dosimetric evaluation of raster-scanning particle beam delivery during simultaneous in-beam magnetic resonance (MR) imaging. Using open MR scanner at treatment room, radiochromic film comparisons for protons, helium and carbon ions, each with without cine imaging, yielded 2D gamma pass rates ≥ 98.8 % a 3 / 1.5 mm criterion, 99.9 5 mm. These results constitute first confirmation that time varying fields gradients do not result in clinically relevant...
Computed tomographic-angiography (CT-A) is becoming more accepted in detecting intracranial circulatory arrest brain death (BD). An international consensus about the use and parameters of this technique currently not established. We examined contrast enhancement CT-A after clinically confirmed BD, compared results with electroencephalography (EEG) Transcranial Doppler Ultrasonography (TCD) findings developed a commonly applicable protocol. Prospective, monocentric study between April 2008...
Summary. The p7 protein of hepatitis C virus (HCV) has been classified into a family viral proteins, designated viroporins that form ion channels. M2 influenza is the prototype viroporin and encodes HXXXW motif constitutes main functional element Alignment different proteins revealed sequence (positions 17–21) also highly conserved among some HCV genotypes. To study putative in p7, five mutants Japanese fulminant 1 strain encoded H17A, H17G, H17E, Y21A Y21W were generated. After transfection...
Summary The p7 protein of hepatitis C virus ( HCV ) is a small, integral membrane that plays critical role in replication. Recently, we reported two intergenotypic JFH 1 chimeric viruses encoding the partial or full‐length ‐A strain genotype 1b GT 1b; Virology ; 2007; 360:134). In this study, determined consensus sequences entire polyprotein coding regions wild‐type and revertant identified predominant amino acid substitutions core K 74 M ), NS 2 T 23 N , H 99 P 5A D 251 G ). Forward genetic...
To describe performance measurements, adaptations and time stability over 20 months of a diagnostic MR scanner for integration into MR-guided photon particle radiotherapy.For realization therapy (MRgRT/MRgPT), 1.5 T was installed at the Heidelberg Ion Beam Therapy Center. integrate MRI treatment process, flat tabletop dedicated coil holders flex coils were used, which prevent deformation patient external contour allow use immobilization tools reproducible positioning. The signal-to-noise...
Abstract Objective. Magnetic resonance (MR) images free of artefacts are pivotal importance for MR-guided ion radiotherapy. This study investigates MR image quality simultaneous irradiation in an experimental setup using phantom imaging as well in-vivo imaging. Observed described within the and their cause is investigated with goal to find conclusions solutions potential future hybrid devices. Approach. An open scanner a field strength 0.25 T has been installed front beamline. Simultaneous...
This study investigates the LET-dependence of dose measurements performed with a nanocomposite Fricke gel (NC-FG) upon irradiation carbon ion beams to address problem quenching dosimeters in high-LET particle therapy. The preparation NC-FG simple device was for atmospheric and anoxic environmental conditions two different container materials. Irradiation at energies 133.39 MeV/u or 194.87 MeV/u, complemented by modulated 10 mm spread-out Bragg peak (SOBP) irradiation. R1 profiles obtained...
Abstract Background Particle therapy makes a noteworthy contribution in the treatment of tumor diseases. In order to be able irradiate from different angles, usually expensive, complex and large gantries are used. Instead rotating beam via gantry, patient itself might rotated. Here we present tolerance compliance volunteers for fully-enclosed rotation system clinical magnetic resonance (MR)-scanner potential use MR-guided radiotherapy, conducted within prospective evaluation study. Methods A...
We aim to assess the magnetic resonance imaging (MRI)-to-CT deformable image registration (DIR) quality of our treatment planning system in pelvic region as first step an online MRI-guided particle therapy clinical workflow. Using 2 different DIR algorithms, ANAtomically CONstrained Deformation Algorithm (ANACONDA), algorithm incorporated RayStation, and Elastix, open-source software, we retrospectively assessed deformed CT (dCT) generation for 5 patients. T1- T2-weighted daily control MRI...
The interaction between the immune system and tumor microenvironment significantly impacts cancer progression treatment response. Macrophages, with their diverse functional states, play a crucial role in this interplay. Identifying accurate markers for macrophage infiltration is vital understanding roles therapeutic potential. Immunai addresses challenge by developing single cell atlases. Employing state-of-the-art RNA sequencing (scRNA-seq) technologies, generates comprehensive...
<title>Abstract</title> Background Particle therapy makes a noteworthy contribution in the treatment of tumor diseases. In order to be able irradiate from different angles, usually expensive, complex and large gantries are used. Instead rotating beam via gantry, patient itself might rotated. Here we present tolerance compliance volunteers for fully-enclosed rotation system clinical magnetic resonance (MR)-scanner potential use MR-guided radiotherapy, conducted within prospective evaluation...
Ziele: Zur Feststellung des Hirntodes sind verschiedene apparative Verfahren als Irreversibilitätsnachweis oder notwendige Ergänzung bei primär infratentoriellen Läsionen durch die Richtlinien der Bundesärztekammer festgelegt. Durch flächendeckende Verfügbarkeit von modernen CT-Geräten werden diese zur Darstellung intrakraniellen Gefäße zunehmend verbreitet. Im Vergleich zu den etablierten cerebralen Zirkulationsstillstandes erscheint Einsatz CT-A aufgrund hohen räumlichen und zeitlichen...
*Johannes Gutenberg University Medical School, Department of Neurosurgery; †Johannes Institute Biostatistics, Mainz, Germany