A5104076908- Catalytic C–H Functionalization Methods
- Circular RNAs in diseases
- Oxidative Organic Chemistry Reactions
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Radical Photochemical Reactions
- MicroRNA in disease regulation
- RNA Research and Splicing
- Mesenchymal stem cell research
- Membrane Separation and Gas Transport
- Vascular anomalies and interventions
- Nuclear Engineering Thermal-Hydraulics
- Advanced Glycation End Products research
- Cancer, Hypoxia, and Metabolism
- Connexins and lens biology
- Photonic and Optical Devices
- Cancer-related gene regulation
- Cardiovascular Syncope and Autonomic Disorders
- Bone Tumor Diagnosis and Treatments
- Biochemical Analysis and Sensing Techniques
- Carbon Dioxide Capture Technologies
- Synthetic Organic Chemistry Methods
- Phase Equilibria and Thermodynamics
- Synthesis and Biological Evaluation
- Sulfur-Based Synthesis Techniques
Jiangxi Agricultural University
2023-2025
Poultry Research Institute
2023-2024
Mudanjiang Medical University
2018-2024
Nanjing Medical University
2013-2024
Liaocheng University
2024
Nanjing University of Chinese Medicine
2021-2023
Yangzhou University
2023
Henan Provincial People's Hospital
2014-2022
Zhengzhou Central Hospital
2022
Henan Provincial Chest Hospital
2015
A direct and site-specific alkylation of (sp3)C-H bond with aliphatic boronic acid was achieved. By simply heating glycinates amines together alkylboronic acids under an oxygen atmosphere, a variety unnatural α-amino peptides could be obtained in good yields.
Abstract Methyltransferase-like 3 (METTL3) is a crucial element of N6-methyladenosine (m 6 A) modifications and has been extensively studied for its involvement in diverse biological pathological processes. In this study, we explored how METTL3 affects the differentiation stem cells from apical papilla (SCAPs) into odonto/osteoblastic lineages through gain- loss-of-function experiments. The m A modification levels were assessed using dot blot activity quantification addition, employed Me-RIP...
Abstract We report herein a modified Clemmensen reduction. When reacted with aqueous H(D)Cl in an undivided cell, aliphatic and aromatic aldehydes ketones undergo deoxygenative hydrogenation deuterization to give hydrocarbons deuterocarbons. The general features of this transformation are: 1) H + /D as the sources H/D; 2) mild reaction conditions (room temperature, open flask, CH 3 CN water cosolvent); 3) easily scaled‐up 100 grams. A series D‐labeled drugs were synthesized by method. magnified image
Duck meat is pivotal in providing high-quality protein for human nutrition, underscoring the importance of studying duck myogenesis. The regulatory mechanisms governing myogenesis involve both coding and non-coding RNAs, yet their specific expression patterns molecular remain elusive. To address this knowledge gap, we performed profiling analyses mRNAs, lncRNAs, circRNAs, miRNAs involved using whole-transcriptome RNA-seq. Our analysis identified 1733 differentially expressed (DE)-mRNAs, 1116...
Mitochondrial dysfunction induced by myocardial ischemia is the primary cause of cardiac cell death. Specific removal damaged mitochondria through mitophagy may be beneficial for cardiomyocyte protection against ischemia. Regulator calcineurin 1-1L (Rcan1-1L) has been implicated in induction neurons. However, whether or not Rcan1-1L can evoke cardiomyocytes during hypoxia remains unknown. This study aims to investigate effect overexpression on and possible underlying mechanism. The results...
A site-specific oxidation of (sp3)C–C(sp3) and (sp3)C–H bonds in aryl alkanes by the use NaNO2/HCl was explored. The method is chemical-oxidant-free, transition-metal-free, uses water as solvent, proceeds under mild conditions, making it valuable attractive to synthetic organic chemistry.
Quail, as an advantageous avian model organism due to its compact size and short reproductive cycle, holds substantial potential for enhancing our understanding of skeletal muscle development. The quantity represents a vital economic trait in poultry production. Unraveling the molecular mechanisms governing quail development is paramount importance optimizing meat egg yield through selective breeding programs. However, comprehensive characterization regulatory dynamics control underpinning...
An electrochemistry-promoted oxidative cleavage of (sp3)C-C(sp3)/H bonds in alkylarenes was developed. Various aryl alkanes can be smoothly converted into ketones/aldehydes under aerobic conditions using a user-friendly undivided cell setup. The features air as oxidant, scalability, and mild make them attractive synthetic organic chemistry.
Background: Degradation of pro-inflammatory macrophage-mediated connexin 43 (Cx43) plays an important role in post-myocardial infarction (MI) arrhythmogenesis, microRNA (miR)-155 produced by macrophages has been shown to mediate post-MI effects. We hypothesized that miR-155 inhibition attenuated MI-induced Cx43 degradation reducing macrophage activation. Methods: MI was induced permanent ligation the left anterior descending coronary artery male C57BL/6 mice. Lipopolysaccharide...
Abstract We reported herein an electrochemically reductive alkylation, allylation and propargylation of quinoxalin‐2(1 H )‐ones with haloalkanes. In undivided cell, treatment alkyl halides constant current, a wide range 3‐alkylated‐3,4‐dihydroquinoxalin‐2(1 )‐one its derivatives can be isolated in 25–87% yields. magnified image
Abstract The previous strategies for oxidative cleavage of 2,3‐double bond substituted indoles generally suffered from usage heavy metals, stoichiometric chemical oxidants or hash conditions. Herein, we reported an electrochemistry‐driven aerobic C(2)=C(3)/C(2)−N bonds indoles. Through undivided cell, various and its derivatives can be converted into the corresponding ortho ‐amino aryl ketones. This method features metal‐free, air‐as‐oxidant easy scalability. magnified image
Stem cells derived from the apical papilla (SCAPs) play a crucial role in tooth root development and dental pulp regeneration. They are important seed for bone/tooth tissue engineering. However, replicative senescence remains an unavoidable issue as vitro amplification increases. This study investigated effect of three-dimensional (3D) culture environment constructed with methylcellulose on SCAPs senescence. It was observed that 3D conditions can delay cellular senescence, potentially due to...
Increasing evidence has suggested that microRNAs (miRNAs; miRs) are extensively involved in the progression of chondrosarcoma (CHS). However, few studies have investigated functional role miR-525 CHS tissues and cells. In present study, it was discovered levels were decreased Dual luciferase assays indicated F-spondin 1 (SPON1) is a target gene microRNA (miR)-525. addition, overexpression suppressed SW1353 cell migration invasion enhanced apoptosis. Increased SPON1 expression identified...
Objectives: This study was designed to observe the efficacy and safety of renal denervation from inside outside arteries. Methods: Fourteen beagles were randomly divided into a control group (n = 4) treatment 10). One artery in every beagle assigned an intimal (10 arteries) which underwent percutaneous inside, another adventitial by laparotomy. Results: Compared with group, norepinephrine (NE) concentration had significantly decreased (p 0.003) at 3 months postsurgery. Renal HE staining...
A highly sensitive optical fiber Fabry–Perot interferometer (FPI) for strain measurement with temperature compensation is proposed. Instead of using another actual reference interferometer, a virtual FPI constructed to superpose the sensing form Vernier effect. The fundamental and first-order harmonic effect are generated increase sensitivity by adjusting parameter FPI. In order separate from environment temperature, an FBG cascaded distinguish applied temperature. Experimental results...
Pigeons and certain other avian species produce a milk-like secretion in their crop sacs to nourish offspring, yet the detailed processes involved are not fully elucidated. This study investigated of 225-day-old unpaired non-lactating male pigeons (MN) males initiating lactation on first day after incubation (ML). Using RNA sequencing, ribosome profiling, single-cell transcriptome sequencing (scRNA-seq), we identified significant up-regulation genes associated with assembly protein synthesis...
The duck industry is vital for supplying high-quality protein, making research into the development of skeletal muscle critical improving meat and egg production. In this study, we leveraged Oxford Nanopore Technologies (ONT) sequencing to perform full-length transcriptome myoblasts harvested from leg muscles embryos at embryonic day 13 (E13), specifically examining both proliferative (GM) differentiation (DM) phases. Our analysis identified a total 5797 novel transcripts along with 2332...