A5043642634- Occupational and environmental lung diseases
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Cystic Fibrosis Research Advances
- Pleural and Pulmonary Diseases
- Pediatric health and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Phagocytosis and Immune Regulation
- Cancer Research and Treatments
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- Neonatal Respiratory Health Research
- Medical Imaging and Pathology Studies
- Congenital Diaphragmatic Hernia Studies
- SARS-CoV-2 and COVID-19 Research
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Peptidase Inhibition and Analysis
Sotiria General Hospital
2022-2025
National and Kapodistrian University of Athens
2017-2023
Evangelismos Hospital
2017-2023
Chest Diseases Hospital
2022
Chronic infection and inflammation shapes the airway microbiome in bronchiectasis. Utilizing whole-genome shotgun metagenomics to analyze resistome provides insight into interplay between microbes, resistance genes, clinical outcomes.
Colony-Stimulating Factor 1 (CSF1)/Colony-Stimulating Receptor (CSF1R) signaling orchestrates tumor-associated macrophage (TAM) recruitment and polarization towards a pro-tumor M2 phenotype, the dominant phenotype of TAMs infiltrating mesothelioma tumors. We hypothesized that CSF1/CSF1R inhibition would halt growth by targeting immunosuppressive macrophages unleashing efficient T cell responses. also blockade enhance efficacy PDL1 inhibitor which directly activates CD8+ cells. tested...
Immunomodulators tocilizumab and baricitinib have been used for the treatment of severe COVID-19, however, there are only few published studies comparing their efficacy. All consecutive non-ICU hospitalized COVID-19 patients who received or tocilizumab, were included retrospectively. Primary outcomes mortality intubation on day 14, time to oxygen therapy weaning duration hospitalization. Safety was measured as treatment-related adverse events. 321 with (mean age 62.4 years ± 14.7); 241...
Malignant pleural effusion (MPE) is an incurable common manifestation of many malignancies. Its formation orchestrated by complex interactions among tumor cells, inflammatory and the vasculature. Tumor-associated macrophages present dominant population MPE, M2 macrophage numbers account for dismal prognosis. polarization known to be triggered CSF1/CSF1 receptor (CSF1R) signaling. We hypothesized that CSF1R+ favor MPE could therapeutically targeted limit MPE. generated mice with...
MTH1 protects tumor cells and their supporting endothelium from lethal DNA damage triggered by oxidative stress in the microenvironment, thus promoting growth. The impact of on tumor-related immune compartment remains unknown. We hypothesized that regulates fitness therefore enhances activity currently used immunotherapeutic regimens.Our hypotheses were validated two syngeneic murine mesothelioma models using clinically relevant inhibitor, karonudib. also examined effect combined PD-L1...
Oxidative stress and inadequate redox homeostasis is crucial for tumor initiation progression. MTH1 (NUDT1) enzyme prevents incorporation of oxidized dNTPs by sanitizing the deoxynucleoside triphosphate (dNTP) pool therefore vital survival cells. inhibition has been found to inhibit growth several experimental tumors, but its role in mesothelioma progression remained elusive. Moreover, although nonessential normal cells, host cells milieu, especially endothelium, unclear. We validated a...
Purpose: Tocilizumab is associated with positive outcomes in severe COVID-19. We wanted to describe the characteristics of nonresponders treatment. Methods: This was a retrospective multicenter study two respiratory departments investigating adverse at 90 days from diagnosis subjects treated tocilizumab (8 mg/kg intravenously single dose) for progressive Results: Of 121 subjects, 62% were males, and 9% fully vaccinated. Ninety-six (79.4%) survived, 25 died (20.6%). Compared survivors (S),...
Immunomodulators including tocilizumab and baricitinib have been used for the treatment of severe COVID-19, however, studies comparing their efficacy are lacking. We aimed to compare safety effectiveness in COVID-19. <b>Methods:</b> All consecutive non-ICU hospitalized COVID-19 patients, from May 2021 July 2022, who were admitted our departments received or as add-on therapy, included retrospectively. Demographics, clinical laboratory data recorded. Primary outcomes mortality intubation on...
<b>Introduction:</b> ERS guidelines suggest the use of inhaled antibiotics in patients with bronchiectasis and chronic P. aeruginosa (PA) infection. However, none them has been approved so far. <b>Aims objectives:</b> To evaluate efficacy safety tobramycin inhalation solution (TIS), Vantobra (Specialty Theurapeutics), adult PA sputum. <b>Methods:</b> We prospectively enroll clinically stable sputum (chronic infection or first isolation) followed up our reference center. They receive...
MTH1 enzyme sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. targeting promotes tumor cell apoptosis without affecting normal cells . Moreover, it reduces ROS levels implying an additional anti-inflammatory and anti-angiogenic role. Since MPM initiation progression are associated with oxidative stress genotoxic damage, we assumed that MTH-1 presents a reasonable target for treatment. We hypothesized pharmacological the protein would abrogate...
<b>Introduction:</b> Tumor associated macrophages (TAMs), mainly those of a pro-tumor (M2) phenotype, are believed to contribute malignant pleural effusion (MPE) formation. Colony Stimulating Factor-1 Receptor (CSF1R) activation polarizes macrophage towards an M2 phenotype. <b>Objectives:</b> To examine the role CSF1R in experimental MPE: we hypothesized that targeting would limit Lewis Lung Adenocarcinoma (LLC)-induced MPE by modulating immune tumor/pleural microenvironment, attenuate...
<title>Abstract</title> Purpose Tocilizumab is associated with positive outcomes in severe Covid-19. We wanted to describe the characteristics of non-responders treatment. Methods Retrospective multi-center study two respiratory departments, investigating adverse at 90 days from diagnosis subjects treated tocilizumab (8mg/kg intravenously single dose) for progressive covid-19. Results 121 subjects, 62% males, 9% fully vaccinated. 96 (79.4%) survived and 25 died (20.6%). Compared survivors...
<b>Introduction:</b> Primary ciliary dyskinesia (PCD) is a heterogeneous genetic disease characterized by motile dysfunction. Data on adult population remains limited. We herein aim to report the clinical and radiological features of Greek PCD cohort. <b>Methods:</b> reviewed retrospectively laboratory information patients from single reference center for bronchiectasis. Chest HRCTs were scored bronchiectasis morphology, distribution associated findings. <b>Results:</b> 15 studied. Mean...