A5076276862- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Tracheal and airway disorders
- Cystic Fibrosis Research Advances
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Mechanical Circulatory Support Devices
- Vascular Anomalies and Treatments
- Neonatal Respiratory Health Research
- Smoking Behavior and Cessation
- COVID-19 and healthcare impacts
- Neurological and metabolic disorders
- Drug-Induced Adverse Reactions
- Global Public Health Policies and Epidemiology
- Asthma and respiratory diseases
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Acute Kidney Injury Research
- Education, Sociology, Communication Studies
- Educational Methods and Media Use
- Esophageal and GI Pathology
- Social and Behavioral Studies
- Cardiac Structural Anomalies and Repair
- Respiratory and Cough-Related Research
Singapore General Hospital
2017-2024
Guy's and St Thomas' NHS Foundation Trust
2022
St Thomas' Hospital
2022
University Health System
2020-2021
National University Health System
2020-2021
National University Cancer Institute, Singapore
2020-2021
SingHealth
2020
Chronic infection and inflammation shapes the airway microbiome in bronchiectasis. Utilizing whole-genome shotgun metagenomics to analyze resistome provides insight into interplay between microbes, resistance genes, clinical outcomes.
Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation and infective exacerbations, however, in-vitro model systems for the study of host-pathogen interaction at individual level are lacking. Here, we describe establishment nasopharyngeal bronchial organoids from healthy individuals COPD that recapitulate level. In contrast to organoids, goblet cell hyperplasia reduced ciliary beat frequency were observed in hallmark features disease. Single-cell transcriptomics...
A major challenge with the treatment of obstructive sleep apnoea (OSA) is adherence to continuous positive airway pressure (CPAP) therapy. Mask tolerability an important determinant adherence, however evidence guide selection mask interfaces lacking.We conducted a randomized crossover trial in CPAP therapy for moderate-to-severe OSA assess and efficacy nasal mask, pillow oronasal masks. Demographic data, Nasal Obstruction Symptom Evaluation (NOSE) scores craniofacial measurements were also...
Abstract Background Acute kidney injury (AKI) is a frequent complication in patients with severe respiratory failure receiving extracorporeal membrane oxygenation (ECMO). However, little known of long-term function ECMO survivors. We aimed to assess the mortality and outcomes adult treated veno-venous (VV-ECMO). Methods This was single-centre retrospective study (≥ 18 years old) who were VV-ECMO at commissioned centre UK between 1st September 2010, 30th November 2016. AKI defined staged...
Patients with tracheobronchial stenosis due to tuberculosis (TSTB) have a variable clinical course and response treatment including airway intervention. There are no clear guidelines on the best approach manage such patients. This study examines long-term outcomes of patients TSTB factors associated recurrent symptoms or need for repeat intervention following initial bronchoscopic intervention.This is retrospective analysis over an 18-year period. Symptoms, radiological, findings,...
Venovenous extracorporeal membrane oxygenation is increasingly being established as a treatment option for severe acute respiratory failure. We sought to evaluate the impact of dedicated specialist team-based approach on patient outcomes.Retrospective cohort study.Single-center medical ICU in an academic tertiary hospital.Adult patients initiated venovenous failure.Initiation intensivist-led multidisciplinary team; critical decisions management were jointly made by team intensivists,...
Abstract Background Arterial and venous thrombosis are reported to be common in critically ill COVID-19 patients. Method results This is a national multicenter retrospective observational study involving all consecutive adult patients who required intensive care units (ICU) admission between 23 January 2020 30 April Singapore. One hundred eleven were included the arterial thrombotic rates ICU 1.8% ( n = 2) 9.9% 11), respectively. Major bleeding rate was 14.8% 16). Conclusions Critically...
Introduction: Non-cystic fibrosis bronchiectasis (NCFB) is a highly heterogenous disease. We describe the clinical characteristics of NCFB patients and evaluate performance Bronchiectasis Severity Index (BSI) in predicting mortality. Methods: Patients attending clinic between August 2015 April 2020 with radiologically proven on computed tomography were recruited. Clinical characteristics, spirometry, radiology, microbiology course over median period 2.4 years presented. Results: A total 168...
Recent studies have reported that COVID-19 infected patients with stroke, who were often in the older age group, had a higher incidence of vascular risk factors, and more severe infection related respiratory symptoms. These observations provided little evidence to suggest is potential causative factor for stroke. This report describes young patient cerebellar stroke secondary infection.A 45-year old male presented at hospital, reporting two-day history headache, vertigo, persistent vomiting,...
Abstract Background: Arterial and venous thrombosis are reported to be common in critically ill COVID-19 patients.Method Results: This is a national multicenter retrospective observational study involving all consecutive adult patients who required intensive care units (ICU) admission between 23 January 2020 30 April Singapore. 111 were included the arterial thrombotic rates ICU 1.8% (n=2) 9.9% (n=11), respectively. Major bleeding rate was 14.8% (n=16). Conclusions: Critically Singapore have...
Background: Early mobilisation in the intensive care unit has been suggested to improve outcomes. However, safety and practical concerns have led slow uptake of early mobilisation. Objectives: We designed a study evaluate practicability efficacy an protocol patients. Methods: performed prospective non-blinded observational cohort based on quality improvement project. implemented for suitable patients admitted medical surgical units tertiary hospital. All other aspects patient were managed as...
<b>Aims and Objectives:</b> There is paucity of literature regarding haemoptysis in non-cystic fibrosis bronchiectasis (NCFB) patients. We sought to describe compare the characteristics patients with without a history haemoptysis. <b>Methods:</b> Data who were followed up specialist clinic at Singapore General Hospital prospectively collected since August 2015. Demographic characteristics, disease etiology, sputum microbiology, lung function testing chest radiology findings analyzed using...
Abstract Background: Arterial and venous thrombosis are reported to be common in critically ill COVID-19 patients. Method Results: This is a national multicenter retrospective observational study involving all consecutive adult patients who required intensive care units (ICU) admission between 23 January 2020 30 April Singapore. 111 were included the arterial thrombotic rates ICU 1.8% (n=2) 9.9% (n=11), respectively. Major bleeding rate was 14.8% (n=16). Conclusions: Critically Singapore...
<b>Introduction:</b> Globally, SARS-CoV-2 variants with varying virulence and transmissibility are emerging. Higher risks of severe COVID-19 including death in chronic obstructive pulmonary disease (COPD) proposed therefore assessing airway tissue tropism relation to COPD is critical better understand outcomes this high-risk group. <b>Methods:</b> We established human organoid models from adult stem cells representative the upper lower healthy individuals evaluated infectivity,...