A5032034630- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Retinal Diseases and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Pregnancy and preeclampsia studies
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical effects in animals
- Protease and Inhibitor Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Fatty Acid Research and Health
Erasmus MC
2011-2024
Erasmus University Rotterdam
2019-2024
Amsterdam UMC Location University of Amsterdam
2011-2012
Xenon Pharmaceuticals (Canada)
2012
Montreal Heart Institute
2012
Université de Montréal
2012
Leiden University Medical Center
2011
University of Bonn
2011
Maastricht University
2011
We previously demonstrated that diet supplementation with seaweed Sargassum fusiforme (S. fusiforme) prevented AD-related pathology in a mouse model of Alzheimer’s Disease (AD). Here, we tested lipid extract Himanthalia elongata (H. elongata) and supercritical fluid (SCF) S. is free excess inorganic arsenic. Diet H. cognitive deterioration APPswePS1ΔE9 mice. Similar trends were observed for the SCF extract. The cerebral amyloid-β plaque load remained unaffected. However, IHC analysis...
Endothelial lipase is a phospholipase with activity against high-density lipoprotein. Although small number of mutations in LIPG have been described, the role protection atherosclerosis unclear.We identified 8 loss-of-function (LOF) individuals lipoprotein cholesterol. Functional analysis confirmed that most rare abolish vitro, indicating complete LOF, whereas 2 more common N396S and R476W reduce by ≈50%, partial LOF implying ≈50% ≈75% remaining endothelial function heterozygous mutation...
Abstract Background Coronary heart disease ( CHD ) risk inversely associates with levels of high‐density lipoprotein cholesterol HDL ‐C). The protective effect is thought to depend on its functionality, such as ability induce efflux. Materials and methods We compared plasma efflux capacity between male familial hypercholesterolaemia FH patients without relative their non‐ brothers, examined constituents including sphingosine‐1‐phosphate (S1P) carrier apolipoprotein M (apoM). Results Seven...
Background— In humans, the E4 allele of apolipoprotein E gene is associated with increased coronary heart disease risk. Surprisingly, in rodents, only accelerates atherosclerotic process when transgenic for human low-density lipoprotein receptor (LDLR) protein. We therefore investigated whether LDLR locus interacted genotype on risk patients clinically diagnosed familial hypercholesterolemia and without mutation. presence an mutation diminishing function was protective E4/E4 carriers....
Purpose: Diabetic retinopathy (DR) is a complication of type 2 diabetes mellitus (T2DM). Lipoprotein(a) (Lp(a)) contributes to the progression DR, but how unclear. In homeostasis retinal microvasculature, myeloid-derived pro-angiogenic cells (PACs) also play pivotal role, and fail function properly in diabetic conditions. Here, we explored putative contribution Lp(a) from patients with T2DM with/without DR healthy controls on inflammation angiogenesis endothelial (RECs), PAC differentiation....
Abstract Hypercholesterolemia is characterized by elevated low‐density lipoprotein (LDL)‐cholesterol levels and an increased risk of cardiovascular disease. The adipokine chemerin additional factor. Here we investigated whether cholesterol‐lowering with statins or proprotein convertase subtilisin‐kexin type 9 inhibitors (PCSK9i) affects chemerin. Both PCKS9i lowered plasma LDL‐cholesterol, triglycerides total cholesterol in hypercholesterolemic patients, high‐density (HDL)‐cholesterol. Yet,...
Apolipoprotein Isoform E4 Does Not Increase Coronary Heart Disease Risk in Carriers of Low-Density Lipoprotein Receptor Mutations"In our article, we show less increased coronary heart disease (CHD) risk familial hypercholesterolemia (FH) patients with a low-density lipoprotein receptor (LDLR) mutation and the APOE4/E4 genotype. 1We give several possible explanations, including decreased trapping at surface hepatocytes when fewer LDL receptors are available.These scenarios could have been...
Background: Familial hypercholesterolemia (FH) is characterized by severe elevations in circulating LDL-cholesterol, and an increase the risk of dyslipidemia-related cardiovascular disease (CVD). Chemerin, as a newly identified adipokine, considered additional factor for CVD. Here we investigated whether it can be modified cholesterol-lowering therapy. Methods: Lipoprotein subfractions were isolated density gradient ultracentrifugation. Lipids chemerin concentrations determined both before...