A5004455927- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Tracheal and airway disorders
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Pneumocystis jirovecii pneumonia detection and treatment
- Pleural and Pulmonary Diseases
- Pulmonary Hypertension Research and Treatments
- Airway Management and Intubation Techniques
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Long-Term Effects of COVID-19
- Cancer therapeutics and mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Salivary Gland Tumors Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Hepatitis C virus research
- Polyomavirus and related diseases
- Cardiac tumors and thrombi
- Cancer Diagnosis and Treatment
- Blood groups and transfusion
Yokohama Municipal Citizen's Hospital
2021-2025
National Defense Medical College
2014-2019
Self-Defense Forces Central Hospital
2013
Abstract Introduction The systemic immune-inflammation index (SII) has emerged as a promising prognostic marker in various malignancies. However, its significance patients with small-cell lung cancer (SCLC) treated immune checkpoint inhibitors (ICIs) remains unclear. In this study, we evaluated the impact of SII SCLC after ICI use. Methods Of 62 who received chemoimmunotherapy at our institution between September 2019 and July 2024, retrospectively analyzed 36 subsequently maintenance...
As first-line treatment for stage IV or recurrent non-small cell lung cancer, combination immunotherapy with nivolumab and ipilimumab, without chemotherapy, had demonstrated survival benefits over chemotherapy; however, data on Japanese patients are limited.
Remdesivir has been shown to reduce recovery time and mortality among patients with coronavirus disease 2019 (COVID-19). However, data regarding the efficacy safety of remdesivir use are limited in Japan. We conducted a single-center retrospective cohort study at Yokohama Municipal Citizen's Hospital, Kanagawa, Patients COVID-19 pneumonia treated were included. The onset acute pancreatitis increased pancreatic enzyme levels clinical, laboratory, treatment, outcome collected analyzed. A total...
Abstract Background Granulocyte colony-stimulating factor (G-CSF)-producing lung cancer induces severe inflammation and a high white blood cell (WBC) count is associated with poor prognosis. A recent case of G-CSF-producing adenocarcinoma showed expression programmed death ligand 1 (PD-L1) was treated pembrolizumab as first-line therapy, which extremely effective. We hypothesized that cancers are PD-L1 expression. Methods This retrospective study included patients diagnosed at Yokohama...
Abstract Background The relationship between epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI) resistance, including osimertinib, and programmed cell death‐ligand 1 (PD‐L1) expression status in EGFR ‐mutated non‐small lung carcinoma (NSCLC) remains unclear. Patients Methods We retrospectively analyzed 64 patients with unresectable advanced or metastatic NSCLC carrying exon 19 deletions (ex19del) 21 L858R substitutions (L858R) who received osimertinib as the first‐line...
Abstract Background Cold agglutination syndrome is a subtype of autoimmune hemolytic anemia. The condition referred to as “cold” because the antibodies become active and induce hemolysis at cold temperatures, typically 3–4 °C, which not always case in other kinds Whereas primary may occur absence underlying conditions, secondary associated with presence infections, including coronavirus disease 2019. Case presentation We report 69-year-old Japanese woman periodontitis who was our hospital...
The push and slide method is a of endoscopic bronchial occlusion using an endobronchial Watanabe spigot that facilitates the target bronchus rapidly accurately guidewire. We herein report case man who was diagnosed with empyema forming bronchopulmonary fistulae successfully treated by occlusion. Because multiple fistulae, balloon not favorable therapeutic approach. Instead, used in order to detect fistulae. Endoscopic occlusion, particularly method, may be valid treatment option for
Malignant pericardial mesothelioma (MPM) is a rare tumour that arises from the mesothelial cells of pericardium. No standard treatment has been established owing to poor response; therefore, MPM prognosis. We herein report case in 70-year-old man was diagnosed immunohistopathologically using cell block sections fluid and which long-term survival for more than 3 years achieved with only periodic drainage. Immunohistopathological staining investigations, especially BRCA1-associated protein 1...
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is useful for diagnosing hilar and mediastinal lymph node enlargement; however, specimens obtained are often small inadequate pathologic diagnosis. In June 2017, EchoTip ProCore, a puncture with side trap, was launched in Japan. this single-center prospective interventional study, 57 patients nodes, intrapulmonary tumor or pleural mass were diagnosed using EBUS-TBNA ProCore between 2017 February 2020. performed 53...
Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare manifestation of malignancy. The antemortem diagnosis difficult, since patients present with rapidly progressive symptoms. We recently observed case PTTM following lymphedema the lower extremities. did not reach diagnosis, even after performing BAL and TBLB. patient manifested pulmonary hypertension died on 9th day admission. Autopsy revealed embolism in arterioles accompanied by fibrocellular epithelial cell proliferation, but...
Background/Aim: Survival outcomes in patients with successfully resected non-small-cell lung cancer (NSCLC) are not well understood. Furthermore, the best treatment strategy for postoperative locoregional recurrence has been established. Patients and Methods: who underwent R0 resection of NSCLC between 2013 2022 were retrospectively reviewed. The survival after was analyzed by categorizing into distant groups. Moreover, efficacy salvage local therapy including radiotherapy (RT) concurrent...
<title>Abstract</title> <bold>Introduction</bold> The systemic immune-inflammation index (SII) has emerged as a promising prognostic marker in various malignancies. However, its significance patients with small-cell lung cancer (SCLC) treated immune checkpoint inhibitors (ICIs) remains unclear. In this study, we evaluated the impact of SII SCLC after ICI use. <bold>Methods</bold> Of 62 who received chemoimmunotherapy at our institution between September 2019 and July 2024, retrospectively...
C-ros oncogene 1 (ROS1) translocation is an oncogenic driver-mutation identified in 1-2% of non-small-cell lung cancer (NSCLC) cases. Although crizotinib, a tyrosine kinase inhibitor (TKI) against ALK/ROS1, known to be effective ROS1-fusion-positive NSCLC, such cases sometimes progress with brain metastases. The most frequently reported crizotinib-resistance mutation ROS1 G2032R, and some studies have found that even newly developed TKIs, as entrectinib lorlatinib, show decreased efficacy...
Abstract We report an acute clinical course of pneumonia caused by Legionella pneumophila in a patient receiving chemotherapy for lung cancer and corticosteroid therapy. A 57‐year‐old man presented with fever dyspnoea was admitted to our hospital. Chest computed tomography revealed new left lower infiltrate, tumour progression the right upper region, metastases lymph nodes pleural effusion. The urinary antigen test positive. patient's oxygen requirement increased on day admission, he died...
Abstract Background:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is useful for diagnosing hilar and mediastinal lymph node enlargement; however, specimens obtained are often small inadequate pathologic diagnosis. In June 2017, EchoTip ProCore®, a puncture with side trap, was launched in Japan.Methods:In this single-center prospective interventional study, 57 patients or tracheal tumors were diagnosed using EBUS-TBNA ProCore® between 2017 February 2020.Results:...