A5101984172- SARS-CoV-2 and COVID-19 Research
- Opioid Use Disorder Treatment
- Breast Implant and Reconstruction
- Educational theories and practices
- Substance Abuse Treatment and Outcomes
- Mitochondrial Function and Pathology
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Respiratory viral infections research
- Educational Research and Science Teaching
- RNA regulation and disease
- Health Policy Implementation Science
- Trypanosoma species research and implications
- Oil Palm Production and Sustainability
- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
- Viral Infections and Vectors
- Ion channel regulation and function
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- Xenotransplantation and immune response
- Calcium signaling and nucleotide metabolism
- Insect Resistance and Genetics
Public Health Agency of Canada
2025
University of Córdoba
2020-2024
International Center for Transitional Justice
2024
Electric Vehicle Challenge
2024
Haemophilia Foundation Australia
2024
Centro de Investigación de la Caña de Azúcar de Colombia
2023
University of Chile
2006-2022
Texas A&M University
1992-2020
Universidad del Valle
2020
Walker (United States)
2020
In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). This process is associated with cell death. We investigated whether activation apoptosis ceramides affects mitochondrial dynamics promotes in cardiomyocytes. Neonatal rat cardiomyocytes were incubated C2-ceramide or the inactive analog dihydro-C2-ceramide for up to 6 h. Three-dimensional images cells loaded mitotracker green obtained by...
Skeletal muscle is one of the main physiological targets insulin, a hormone that triggers complex signaling cascade and enhances production reactive oxygen species (ROS) in different cell types. ROS, currently considered second messengers, produce redox modifications proteins such as ion channels induce changes their functional properties. In myotubes, insulin also calcium release from intracellular stores. this work, we studied myotubes whether stimulated ROS investigated mechanisms...
Abstract. Geometric morphometrics is a novel approach to biological shape analysis, and its application medical entomology just beginning. Here, we use it examine geographical interspecific variation in the Triatoma infestans complex, vectors of Chagas disease southern Latin America. Using six landmarks defining membranous part hemelytra, analysed patterns several populations T . , including recently described ‘dark morph’ from hollow trees Bolivian Chaco. As potential outgroup, T....
Foreign secretory pathway proteins are often produced in surprisingly low amounts the baculovirus/insect cell expression system. One possible reason for this is that heterologous signal peptides might be inefficiently recognized by insect protein translocation machinery. This idea was supported a recent study showing secretion of plant baculovirus system enhanced when its peptide replaced with an insect-derived (Tessier, D. C., Thomas, Y., Khouri, H. E., Laliberte, F., and Vernet, T. (1991)...
Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer´s disease, trigger persistent and low magnitude Ca2+ signals neurons. We reported previously that these signals, which arise from entry subsequent amplification by release through ryanodine receptor (RyR) channels, promote mitochondrial network fragmentation reduce RyR2 expression. Here, we examined if AβOs, inducing redox sensitive RyR-mediated release, stimulate Ca2+-uptake, ROS generation fragmentation,...
Abstract Background The aim, of the study was to estimate accuracy magnetic resonance imaging (MRI) in assessing residual disease breast cancer patients receiving neoadjuvant chemotherapy (NAC) and identify clinico-pathological factors that affect diagnostic MRI determine tumour size following NAC. Patients methods 91 undergoing NAC (92 lesions) were included study. Breast performed at baseline after completion Treatment response evaluated by histopathological examination investigate ability...
ObjectivesWe investigated seroreactivity by using a commercial SARS-CoV-2 ELISA test in samples collected from different groups of individuals, including patients diagnosed to have Dengue, Zika, and Chikungunya infection between 2015 2019, an endemic area the Caribbean Colombian region.MethodsA total 127 sera obtained six individuals were included this study: Group A: with confirmed infection; B: symptoms suggestive COVID-19 or asymptomatic contacts patients; C: acute recent dengue virus D:...
The quantification of colocalizing signals in multichannel fluorescence microscopy images depends on the reliable segmentation corresponding regions interest, selection appropriate colocalization coefficients, and a robust statistical criterion to discriminate true from random colocalization. Here, we introduce confined displacement algorithm based image correlation spectroscopy combination with Manders coefficients M1(ROI) M2(ROI) quantify given florescence pattern. We show that existing...
Abstract A serological survey was carried out in Monteria (500 000 population), a mid-size city Colombia. An overall prevalence of 55.3% (95% confidence interval, 52.5%–57.8%) found among sample 1.368 people randomly selected from the population. Test positivity related to economic characteristics with highest most impoverished areas, representing 83.8% city’s We that might be associated some important level population immunity.
Polyhedrin is the major component of nuclear viral occlusions produced during replication baculovirus Autographa californica multicapsid polyhedrosis virus (AcMNPV). Since are responsible for horizontal transmission AcMNPV in nature, biosynthesis, localization, and assembly polyhedrin important events cycle. We recently defined sequence requirements localization polyhedrin. In this study, we examined at different times infection. The results showed that becomes more efficient as occlusion...
Tetanic electrical stimulation of myotubes evokes a ryanodine receptor-related fast calcium signal, during the stimulation, followed by phospholipase C/inositol 1,4,5-trisphosphate-dependent slow signal few seconds after stimulus end. L-type channels (Cav 1.1, dihydropyridine receptors) acting as voltage sensors activate an unknown signaling pathway involved in C activation. We demonstrated that both G protein and phosphatidylinositol 3-kinase were activated inositol 1,4,5-trisphosphate rise...
Abstract Background People with opioid use disorder (OUD) are frequently in contact the court system and have markedly higher rates of fatal overdose. Opioid intervention courts (OIC) were developed to address increasing overdose among defendants by engaging staff identification treatment need referral for opioid-related services building collaborations between OUD systems. The study goal was understand implementation barriers facilitators referring OIC clients treatment. Methods...
The opioid intervention court (OIC) is an innovative, pre-plea treatment to facilitate rapid linkage medications for use disorder (MOUD) people at risk of overdose. This study compares participants in OIC and with problems a traditional drug model on (i) initiation any substance (SU) treatment, (ii) MOUD, (iii) number days MOUD initiation, (iv) retention the program/retention MOUD.
Cultivars from crossings between Elaeis oleífera x guineensis (OxG hybrids) have proven to partial resistance Bud Rot (BR), the most challenging disease for Colombian palm oil agroindustry. Therefore, OxG hybrids were planted in areas that experienced BR outbreaks since 2007. Soon, it was discovered hybrid female inflorescences required be pollinated with pollen E. improve bunch formation. Researchers Cenipalma noted bunches a greater proportion of partenocarpic fruits. The latter generated...