A5076364782- Pancreatitis Pathology and Treatment
- Inflammatory Bowel Disease
- Gastrointestinal motility and disorders
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Digestive system and related health
- Gut microbiota and health
- Gastrointestinal disorders and treatments
- Infant Health and Development
- Intracranial Aneurysms: Treatment and Complications
- Parathyroid Disorders and Treatments
- Eosinophilic Esophagitis
- Human Health and Disease
- Global Health Care Issues
- Suicide and Self-Harm Studies
- Diet and metabolism studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Gastroesophageal reflux and treatments
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Neuroendocrine Tumor Research Advances
Medical University of Sofia
2014-2022
Queen Giovanna Hospital
2015-2021
Medical University of Silesia
2021
National Center of Public Health and Analyses
2017-2021
Weatherford College
2020
Pfizer (United Kingdom)
2020
St. Josef Krankenhaus
2018
Saarland University
2018
Military Medical Academy
2014-2015
Quarantine with social distancing has reduced transmission of COVID-19; however, fear the disease and these remedial measures cause anxiety stress. It is not known whether events have impacted prevalence gastrointestinal (GI) symptoms disorders brain-gut interaction (DGBI).An online platform evaluated GI during COVID-19 pandemic. Data collection utilized validated questionnaires was fully anonymized. Findings were compared identical data acquired in 2019. The association results stress...
In this study, we aimed to evaluate the role of serum trefoil factor 3 (TFF3) as a biomarker disease activity in patients with inflammatory bowel (IBD) and compare TFF3 values those fecal calprotectin (FC).128 IBD were divided into four groups: 1) active ulcerative colitis (UC); 2) quiescent UC; 3) Crohn's (CD); 4) CD. The levels FC assessed all 16 controls.Patients UC had higher than (p<0.001), (p<0.001) or CD controls (p <0.001). We found correlation between (r = 0.478, p 0.006) (r=0.528,...
Aims: We aimed to evaluate the prevalence of irritable bowel syndrome (IBS), functional dyspepsia (FD), and their overlap (OS) in Bulgarian population assess risk factors associated with these disorders.
 Methods: sent an internet-based survey adults. The collected data on socio- demographic, behavioral lifestyle characteristics, diagnostic questions following Rome IV criteria IBS, FD occurrence.
 Results: Data was from 1,896 individuals (mean age = 35.5 years, 18-65, SD=11.7),...
Aim: In the current study we aimed to evaluate role of trefoil factor 3 (TFF3) as a marker for complete mucosal healing (MH) in patients with ulcerative colitis (UC). Methods: We enrolled 116 consecutive UC patients. Trefoil levels were measured by ELISA and compared clinical activity, assessed Lichtiger Index, fecal calprotectin (FCP) C-reactive protein (CRP) levels. Colonoscopy was performed all findings graded according Mayo endoscopic score (EMS) index severity (UCEIS). Results:...
Probiotics possibly affect local and systemic immune reactions maintain the intestinal homeostasis in healthy individuals patients with diseases such as irritable bowel syndrome (IBS). In this single-center, blinded trial, we enrolled 40 (20 IBS 20 individuals) whose blood fecal samples were collected before after a 21-day administration of product comprising Lactobacillus spp., larch arabinogalactan, colostrum. The percentage HLA-DR+ natural killer (NK) cells was higher (p = 0.03) than...
Aims: In the current study we aimed to explore prevalence of gastrointestinal (GI) manifestations in hereditary transthyretin amyloid (hATTR) amyloidosis associated with Glu89Gln mutation.
 Methods: We recruited 78 patients hATTR mutation. The diagnosis was defined by a documented mutation through DNA analysis. Symptoms were recorded as present or absent at time enrollment into study. symptoms checklist included following items: early satiety, nausea, vomiting, constipation, alternating...
Abstract Transthyretin amyloid (ATTR) amyloidosis is a rare systemic disorder characterized by deposits formed misfolded monomers of the transthyretin. Gastrointestinal (GI) manifestations are common in ATTR amyloidosis; however, their pathogenesis not fully elucidated. In present study, we aim to evaluate diagnostic role fecal calprotectin (FC) patients with GI manifestations. We recruited 21 consecutive and 42 sex age-matched healthy controls. The presentation symptoms severity peripheral...
Transthyretin amyloidosis (ATTR) is a rare, progressive, life-threatening, hereditary disorder caused by mutations in the transthyretin gene. Due to phenotypic heterogeneity, ATTR difficult recognize and it often diagnosed very late. In gastrointestinal (GI) disorders play an important role patients' morbidity mortality. some cases, GI symptoms are present even before onset of peripheral polyneuropathy. However, complaints various really differentiate them from other disorders. We 61-year...
It is essential in clinical management to determine the disease activity ulcerative colitis (UC) patients. At present, most accurate way of evaluating UC severity endoscopy with biopsy. Fecal calprotectin (FCP) a non-invasive biomarker that frequently used for monitoring intestinal inflammation.The purpose our study was assess role FCP as noninvasive indicator activity.This prospective enrolled 116 patients (56 quiescent and 60 active UC) 36 controls, referred colonoscopy Center. Colonoscopy...
To evaluate the effects of clinical predictors such as age, duration disease, sex, and smoking on frequency relapses in IBD patients.This study recruited 289 (133 with CD 156 UC) patients. All were followed-up for 36 months disease. We defined frequently relapsing (≥1/year) patients at least one relapse per year infrequently those less than (<1/year). assessed effect predictors: patients.Sixty-four (48.1%) 69 (51.9%) relapsing. There was a significant association between age (p=0.001; OR...
The global pooled prevalence of gastroesophageal reflux disease (GORD) is approximately 14% and varies significantly according to the country. More population-based studies are needed in regions lacking epidemiological data on GORD, such as Eastern Europe, particularly Bulgaria. This current study aimed evaluate GORD Bulgaria assess risk factors associated with this disorder.An internet-based health survey was sent Bulgarian adults. Individuals were invited complete an online questionnaire...
Background and Aims: Validated questionnaires help to minimize diagnostic bias, standardize symptom assessment achieve comparability between studies centers. In a recent European guideline the adult pediatric carbohydrate perception (aCPQ pCPQ), were recommended be used for diagnosis of intolerances in patients. The implementation this into clinical practice makes availability validated translations necessity.
 Methods: Clinical experts who recognized need these available their own...
We aimed to assess the preoperative rectal cancer angiogenesis with Endorectal Power Doppler Ultrasonography by using Vascularity Index (PDVI) calculated imaging analysis software, and compare it microvessel density (MVD) in surgical specimens PATIENTS AND METHODS: This study included 110 patients (39 females; mean age 61.5 years) cancer. Immunohistochemical staining of anti-CD-31 antibody was used for MVD evaluation. The PDVI each tumor computer-assisted quantification colour pixels.Mean -...
Nakov, Radislav; Sarafov, Stayko; Ventsislav; Gospodinova, Mariana; Tournev, Ivailo Author Information
Autoimmune hepatitis (AIH) is progressive, chronic immunologically mediated inflammatory liver disorder that occurs in children and adults of all ages, predominantly women. AIH can be combined with other autoimmune non-autoimmune conditions. We present a case 32 year-old female three relatively uncommon diseases - two one inherited, making their combination even more rare.
For safe implementation and broader application of fecal microbiota transplantation (FMT), quality controlled stool banking is a must. Establishing bank complex, time-consuming, expensive process, making it real challenge in an Eastern European country. We aimed to establish the first Europe - Bulgaria.A multidisciplinary team gastroenterologists, microbiologists, infectionists, geneticists was set up. used questionnaire based on First FMT Consensus order recruit possible donors. Laboratory...
Transthyretin amyloid (ATTR) amyloidosis is a rare disorder with an adult-onset defined by the accumulation of misfolded fibrils predominantly in peripheral nerves, heart, and digestive tract. The disease characterized two forms - hereditary (ATTRv) or acquired (ATTRwt). Various point mutations transthyretin gene induce form disease. For finding new cases ATTR proper screening, establishment multidisciplinary team Centre Excellence (CoE) essential. CoE provides regular education training for...
Introduction: Endovascular coiling of wide neck cerebral aneurysms is challengeable and bears a high risk coil herniation or migration with parent artery thrombosis distal thromboembolism. Advanced techniques for endovascular treatment complex geometry has been developed, such as: stent-assisted coiling, balloon remodeling, double microcatheter branch protection techniques. Aim: Two the current options coil-embolisation unfavorable aspect ratio (dome/neck) are presented. Material Methods: A...