A5055479424- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- MRI in cancer diagnosis
- Thyroid Disorders and Treatments
- Metastasis and carcinoma case studies
- Cancer Research and Treatments
- Medical Imaging Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Gastrointestinal Tumor Research and Treatment
- Glioma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Acute Kidney Injury Research
- Eosinophilic Disorders and Syndromes
- Renal Diseases and Glomerulopathies
- Liver physiology and pathology
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiopharmaceutical Chemistry and Applications
- Dialysis and Renal Disease Management
- Lung Cancer Treatments and Mutations
- Organ and Tissue Transplantation Research
- Tuberous Sclerosis Complex Research
- Cancer, Lipids, and Metabolism
Tohoku Medical and Pharmaceutical University
2018-2025
Tohoku Medical and Pharmaceutical University Hospital
2020-2022
The Nakamura Hajime Eastern Institute
2020
Toho University
2012-2017
Toho University Medical Center Sakura Hospital
2017
National Institutes of Health
2012
National Institute of Diabetes and Digestive and Kidney Diseases
2012
Yokufukai Hospital
2007-2010
Fujita Health University
1998
Tokyo Metropolitan Komagome Hospital
1994-1995
Since 1983, transcatheter oily chemoembolization (TOCE) with doxorubicin hydrochloride, iodized oil, and gelatin sponge was used in 100 patients hepatocellular carcinoma. Doxorubicin, 40-100 mg (mean, 61.3 mg), mixed 5-20 mL 9.6 mL) of an oil to prepare a water-in-oil emulsion that then infused into the hepatic artery. Both progressive changes blood concentrations its tissue who underwent hepatectomy demonstrated drug released slowly from emulsion. The cumulative survival rate 82.0% for 6...
Dynamic MR imaging and early-phase helical CT for detecting small intrahepatic metastases of hepatocellular carcinoma.H Oi, T Murakami, Kim, M Matsushita, H Kishimoto NakamuraAudio Available | Share
Epiprofin (Epfn), an Sp/KLF family transcription factor that regulates cell proliferation and determines fates, is essential for normal skin, hair follicle, tooth development. We found Epfn was expressed in parathyroid glands, Epfn‐ knockout mice displayed elevated serum hormone (PTH) concentrations, decreased bone volume, intracranial ectopic calcification. To investigate the role of regulation PTH expression, gland explant line culture methods were used. expression to be upregulated...
To evaluate the usefulness of magnetic resonance (MR) imaging in diagnosis extraserosal invasion advanced gastric cancer.MR was performed 48 patients with cancer, and results were correlated histopathologic findings. Images perpendicular to wall cancer obtained spoiled gradient-recalled acquisition steady state (GRASS). The degree serosal classified on basis appearance a low-signal-intensity band around lesion.Advanced appeared as thickened high signal intensity after administration contrast...
Background: Propylthiouracil (PTU) and methimazole (MMI) are drugs that widely used to treat Graves' disease. Although both exert an antithyroid effect primarily by blocking thyroid peroxidase activity, their molecular structure other actions different. We hypothesized PTU MMI may have differential effects on thyroid-specific gene expression function. Methods: The of function were examined in rat FRTL-5 cells using DNA microarray, reverse transcriptase (RT)–polymerase chain reaction (PCR),...
Immunohistochemical studies of the expression protein kinase C isozymes were done in 38 human brain tumors using monoclonal antibodies to three major isozymes: Type I, II, and III. The tumors, with exception 3 medulloblastomas 2 6 pituitary adenomas, showed strong immunoreactivity for III isozyme. Astrocytomas, anaplastic astrocytomas, glioblastomas also weak immunostaining whereas other lacked this staining. Immunoreactivity I was present, although weak, some astrocytic gliomas. There no...
To evaluate the effect of transcatheter arterial chemoembolization (TACE) with iodized oil for hepatocellular carcinoma (HCC), dynamic turbo-fast low angle shot (turbo-FLASH) (TR/TE/flip angle/TI, 8.5/4.6/10/200) MR imaging gadopentetate dimeglumine was performed in 10 patients HCC after TACE and before partial hepatectomy. Immediately 0.05 mmol/kg b.w. administered intravenously, images were obtained first 20 s (early phase). Then, one image every 30 from 1 to 3 min (late phase), at 5 7...
Many genes encoding growth factors, receptors, and transcription factors are induced by the epithelial-mesenchymal interaction during tooth development. Recently, diverse functions of micro RNAs (miRNAs) have been reported in organogenesis disease. miRNAs regulate gene expression inhibiting translation destabilizing mRNAs. However, function development remain poorly understood. We screened produced using a microarray system to clarify role dental RNA-1 (miR-1) showed unique pattern...
To evaluate the effect of transcatheter arterial chemoembolization (TACE) with iodized oil for hepatocellular carcinoma (HCC), dynamic turbo-fast low angle shot (turbo-FLASH) (TR/TE/flip angle/TI, 8.5/4.6/10/200) MR imaging gadopentetate dimeglumine was performed in 10 patients HCC after TACE and before partial hepatectomy. Immediately 0.05 mmol/kg b.w. administered intravenously, images were obtained first 20 s (early phase). Then, one image every 30 from 1 to 3 min (late phase), at 5 7...
Increased central venous pressure in congestive heart failure is responsible for renal dysfunction, which mediated by congestion. Pericyte detachment from capillaries after congestion might trigger fibrogenesis via pericyte-myofibroblast transition (PMT). Platelet-derived growth factor receptors (PDGFRs), are PMT indicators, were upregulated our recently established model. This study was designed to determine whether inhibition of the PDGFR pathway could suppress tubulointerstitial injury...
PURPOSE: To assess the clinical usefulness of magnetic resonance (MR) imaging thyroid gland in Hashimoto thyroiditis. MATERIALS AND METHODS: Signal intensity ratios on spin-echo T1-, proton-density-, and T2-weighted images were measured prospectively 37 patients with thyroiditis (33 women, four men; mean age, 51 years) 10 lymphoma (six 68 years). correlated histopathologic findings function test results stepwise regression analysis. Diagnosis signal was compared morphologic diagnosis by...
Angiomyolipoma, a rare benign liver tumor, was observed in 50-year-old woman examined with US, CT, MR imaging and angiography. Dynamic studies using CT were valuable differentiating the disease from hepatocellular carcinoma fat deposits.
Anal cancer is a relatively rare malignancy [1]. An analysis of the National Cancer Data Base showed that most patients with anal carcinoma (71.1 %) required invasive treatments such as chemoradiation therapy or without surgery, and 5-year overall survival for these was 58.0 % [2]. squamous cell in situ (CIS) accounts almost 10 all carcinomas [3]. Here we present case canal CIS incidentally detected patient at low risk developing cancer. The presence, histology, spread depth invasion tumor...
Resistance to lenvatinib mesylate (LEN), a systemic chemotherapy that can be administered orally, has been major issue for treatment of hepatocellular carcinoma (HCC). Although HCC is the tumor most exhibits intratumoral hypoxia, which shown involved in development resistance, there are no reports LEN resistance under hypoxia. The purpose our study was elucidate mechanism hypoxia using cell lines. We confirmed hypoxic conditions There significant increase IC50 value PLC/PRF/5 cells from...
Myoepithelial cells (MECs) are responsible for receiving stimuli from the central nervous system and translating their responses into form of secretion glandular tissue, including salivary glands (SG), sweet glands, mammary glands. SG MECs cause serous saliva by contracting acini/ductal with acetylcholine (Ach) parasympathetic nerves via muscarinic receptors. To response physiological stimulation, epithelial cell-derived supposed to be induced placed adjacent nerve ends in SGs forming a...
Background: Propylthiouracil (PTU) and methimazole (MMI) are drugs that widely used to treat Graves' disease.Although both exert an antithyroid effect primarily by blocking thyroid peroxidase activity, their molecular structure other actions different.We hypothesized PTU MMI may have differential effects on thyroid-specific gene expression function.Methods: The of function were examined in rat FRTL-5 cells using DNA microarray, reverse transcriptase (RT)-polymerase chain reaction (PCR),...