Matthew Orchard

ORCID: 0009-0009-0538-6217
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About
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Research Areas
  • Aerospace Engineering and Control Systems
  • Advanced Aircraft Design and Technologies
  • Rocket and propulsion systems research
  • Fluid Dynamics and Turbulent Flows
  • Congenital Heart Disease Studies
  • Computational Fluid Dynamics and Aerodynamics
  • Vehicle Noise and Vibration Control
  • Connective tissue disorders research
  • Space Exploration and Technology
  • Family and Patient Care in Intensive Care Units
  • Lung Cancer Treatments and Mutations
  • Aerodynamics and Acoustics in Jet Flows
  • Adolescent and Pediatric Healthcare
  • Protease and Inhibitor Mechanisms
  • Ubiquitin and proteasome pathways
  • Cardiac Structural Anomalies and Repair
  • Acoustic Wave Phenomena Research
  • RNA modifications and cancer
  • Plasma and Flow Control in Aerodynamics
  • Cardiovascular Issues in Pregnancy
  • Defense, Military, and Policy Studies
  • Real-time simulation and control systems
  • Lung Cancer Diagnosis and Treatment

University of Toledo
2023

The Ohio State University
2020

University of Southampton
1999-2003

Abstract Mutations in actin-bundling protein plastin 3 (PLS3) emerged as a cause of congenital osteoporosis, but neither the role PLS3 bone development nor mechanisms underlying PLS3-dependent osteoporosis are understood. Of over 20 identified osteoporosis-linked mutations, we investigated all five that expected to produce full-length protein. One mutations distorted an actin-binding loop second domain and abolished F-actin bundling revealed by cryo-EM reconstruction interaction assays....

10.1038/s41413-020-0095-2 article EN cc-by Bone Research 2020-05-22

Families of children at the worst end congenital heart disease endure a significant burden which is often not clearly delineated in clinical literature. We examined greatest concerns parents whose have Fontan circulation.Parents (N = 107) Australian and New Zealand Registry completed online surveys with open-ended closed questions. A qualitative method approach incorporating thematic analyses was used.The for child circulation were centered on fear death their psychosocial well-being,...

10.1016/j.ijcha.2018.02.008 article EN cc-by-nc-nd IJC Heart & Vasculature 2018-03-01

The compound helicopter has much to offer as a means of expanding the flight envelope rotorcraft. There have been significant amounts research performed, albeit disjointed, and many demonstrator helicopters produced trialled since end Second World War mainly with aim increasing helicopter's maximum forward speed. This paper aims pool this knowledge, along relevant developments in other fields, not only state current level understanding configuration but also use it predict likely...

10.1243/095441003772538570 article EN Proceedings of the Institution of Mechanical Engineers Part G Journal of Aerospace Engineering 2003-06-01

Abstract Compounding offers a way of advancing the performance standard helicopter significantly for moderate increase in complexity through addition wings and/or auxiliary propulsion. The compound configuration has potential advantages increased speed, range, agility, productivity and reduced vibration levels over conventional helicopters. Despite several significant efforts, however, no ever been put into production. This paper looks at three aircraft that came close to being accepted by...

10.1017/s0001924000064526 article EN The Aeronautical Journal 1999-10-01

Translation: The University of Toledo Journal Medical Sciences is the online journal launched by Toledo. Manuscripts will be considered on understanding that they report original work and are not under consideration for publication any other journal. publishes articles reporting experimental results basic or clinical research, case reports, reviews. uses a single blind peer review system each manuscript, based presented in its submission, evaluated two student reviewers one faculty reviewer....

10.46570/utjms.vol11-2023-910 article EN cc-by Translation The University of Toledo Journal of Medical Sciences 2023-12-15

10.4271/2001-01-1562 article EN SAE technical papers on CD-ROM/SAE technical paper series 2001-04-30
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