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Adam Karami

ORCID: 0009-0009-1448-9955
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A5073852871
Research Areas
  • DNA Repair Mechanisms
  • PARP inhibition in cancer therapy
  • DNA and Nucleic Acid Chemistry
  • Acute Myeloid Leukemia Research
  • Epigenetics and DNA Methylation
  • Prostate Cancer Treatment and Research
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Ferroptosis and cancer prognosis
  • Genomics, phytochemicals, and oxidative stress
  • CRISPR and Genetic Engineering
  • Cancer therapeutics and mechanisms
  • Cancer Genomics and Diagnostics
  • Insect Resistance and Genetics
  • Cell death mechanisms and regulation
  • Cancer-related gene regulation

Temple University
 2023-2024

Center for Personalized Cancer Treatment
 2024

 Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

DNA polymerase theta (Polθ, encoded by POLQ gene) plays an essential role in Polθ-mediated end-joining (TMEJ) of double-strand breaks (DSB). Inhibition Polθ is synthetic lethal homologous recombination (HR)-deficient tumor cells. However, DSBs can be also repaired PARP1 and RAD52-mediated mechanisms. Because leukemia cells accumulate spontaneous DSBs, we tested if simultaneous targeting or RAD52 enhance the effect HR-deficient Transformation potential oncogenes inducing BRCA1/2-deficiency...

10.1158/1541-7786.mcr-22-1035 article EN Molecular Cancer Research 2023-06-26
 DNA damage response genes as biomarkers of therapeutic outcomes in acute myeloid leukemia patients
OPENALEX - Publications 
Adam Karami Tomasz Skórski

10.1038/s41375-024-02269-9 article EN cc-by Leukemia 2024-05-11
 Derivation of human primary prostate epithelial cell lines by differentially targeting the CDKN2A locus along with expression of hTERT
OPENALEX - Publications 
Jason S. Wasserman Holly Fowle Rumesa Hashmi Diba Atar Kishan Patel and 9 more Amir Yarmahmoodi Alexander W. MacFarlane Yinfei Tan Edna Cukierman Bojana Gligorijevic Adam Karami Kelly A. Whelan Kerry S. Campbell Xavier Graña

<title>Abstract</title> Prostate cancer (PCa) is the most common diagnosed in men worldwide and second leading cause of cancer-related deaths US males 2022. also represents highest mortality disparity between non-Hispanic blacks whites. However, there a relatively small number prostate normal cell lines compared to other cancers. To identify molecular basis PCa progression, it important have epithelial (PrEC) as karyotypically possible. Our lab recently developed novel methodology for rapid...

10.21203/rs.3.rs-4294058/v1 preprint EN cc-by Research Square (Research Square) 2024-05-06
 Derivation of human primary prostate epithelial cell lines by differentially targeting the CDKN2A locus along with expression of hTERT
OPENALEX - Publications 
Jason S. Wasserman Holly Fowle Rumesa Hashmi Diba Atar Kishan Patel and 9 more Amir Yarmahmoodi Alexander W. MacFarlane Yinfei Tan Edna Cukierman Bojana Gligorijevic Adam Karami Kelly A. Whelan Kerry S. Campbell Xavier Graña

Prostate cancer (PCa) is the most common diagnosed in men worldwide and was second leading cause of cancer-related deaths US males 2022. also represents highest mortality disparity between non-Hispanic blacks whites. However, there a relatively small number prostate normal cell lines compared to other cancers. To identify molecular basis PCa progression, it important have epithelial (PrEC) as karyotypically possible. Our lab recently developed novel methodology for rapid efficient...

10.1038/s41598-024-71306-5 article EN cc-by-nc-nd Scientific Reports 2024-09-02
 Supplementary Figure 2 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S2. Phenotype of Polq-/-;Parp1-/- and Polq-/-;Rad52-/- mice.&lt;/p&gt;

10.1158/1541-7786.27035164 preprint EN 2024-09-16
 Supplementary Figure 1 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S1. Genetic aberrations and mRNA expression variabilities of POLQ, PARP1 RAD52 do not coexist in 519 AML samples from the BEAT-AML cohort.&lt;/p&gt;

10.1158/1541-7786.27035167 preprint EN 2024-09-16
 Supplementary Figure 5 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S5. Targeting Polθ + PARP1 and RAD52 induced dual synthetic lethality against HR-deficient leukemia cells.&lt;/p&gt;

10.1158/1541-7786.27035155 preprint EN 2024-09-16
 Supplementary Figure 4 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S4. Targeting Polθ + PARP and RAD52 induced dual synthetic lethality against HR -deficient MPN cells.&lt;/p&gt;

10.1158/1541-7786.27035158 preprint EN 2024-09-16
 Supplementary Figure 3 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S3. Simultaneous inhibition of Polθ helicase and DNA polymerase activity exerted synergistic effect against RAD54-/- leukemia cells.&lt;/p&gt;

10.1158/1541-7786.27035161 preprint EN 2024-09-16
 Data from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;div&gt;Abstract&lt;p&gt;DNA polymerase theta (Poltheta, encoded by POLQ gene) plays an essential role in Poltheta-mediated end-joining (TMEJ) of DNA double-strand breaks (DSBs). Inhibition Poltheta is synthetic lethal homologous recombination (HR)-deficient tumor cells. However, DSBs can be also repaired PARP1 and RAD52 -mediated mechanisms. Since leukemia cells accumulate spontaneous DSBs, we tested if simultaneous targeting Pol or enhance the effect HR-deficient Transformation...

10.1158/1541-7786.c.6738488.v3 preprint EN 2024-09-16
 Supplementary Figure 4 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S4. Targeting Polθ + PARP and RAD52 induced dual synthetic lethality against HR -deficient MPN cells.&lt;/p&gt;

10.1158/1541-7786.27035158.v1 preprint EN 2024-09-16
 Supplementary Figure 3 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S3. Simultaneous inhibition of Polθ helicase and DNA polymerase activity exerted synergistic effect against RAD54-/- leukemia cells.&lt;/p&gt;

10.1158/1541-7786.27035161.v1 preprint EN 2024-09-16
 Supplementary Figure 1 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S1. Genetic aberrations and mRNA expression variabilities of POLQ, PARP1 RAD52 do not coexist in 519 AML samples from the BEAT-AML cohort.&lt;/p&gt;

10.1158/1541-7786.27035167.v1 preprint EN 2024-09-16
 Supplementary Figure 5 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S5. Targeting Polθ + PARP1 and RAD52 induced dual synthetic lethality against HR-deficient leukemia cells.&lt;/p&gt;

10.1158/1541-7786.27035155.v1 preprint EN 2024-09-16
 Supplementary Figure 2 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S2. Phenotype of Polq-/-;Parp1-/- and Polq-/-;Rad52-/- mice.&lt;/p&gt;

10.1158/1541-7786.27035164.v1 preprint EN 2024-09-16
 ADH5/ALDH2 Dehydrogenases and DNA Polymerase Theta Protect Hematopoietic Cells from Formaldehyde Challenge: Therapeutic Implications
OPENALEX - Publications 
Jessica Atkins Anna-Mariya Kukuyan Małgorzata Drzewiecka Tomasz Śliwiński Monika M. Toma and 3 more Umeshkumar Vekariya Adam Karami Tomasz Skórski

10.1182/blood-2024-199334 article EN Blood 2024-11-05
 Clonal Targeting of DNA Damage Response Pathways Eradicates Myeloproliferative Neoplasms
OPENALEX - Publications 
Monika M. Toma Margaret Nieborowska-Skorska Adam Karami Monika Pępek Tomasz Stokłosa and 1 more Tomasz Skórski

10.1182/blood-2023-174280 article EN Blood 2023-11-02
 Supplementary Figure 2 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S2. Phenotype of Polq-/-;Parp1-/- and Polq-/-;Rad52-/- mice.&lt;/p&gt;

10.1158/1541-7786.24229701 preprint EN cc-by 2023-10-02
 Supplementary Figure 3 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S3. Simultaneous inhibition of Polθ helicase and DNA polymerase activity exerted synergistic effect against RAD54-/- leukemia cells.&lt;/p&gt;

10.1158/1541-7786.24229698 preprint EN cc-by 2023-10-02
 Supplementary Figure 1 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S1. Genetic aberrations and mRNA expression variabilities of POLQ, PARP1 RAD52 do not coexist in 519 AML samples from the BEAT-AML cohort.&lt;/p&gt;

10.1158/1541-7786.24229704 preprint EN cc-by 2023-10-02
 Supplementary Figure 5 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S5. Targeting Polθ + PARP1 and RAD52 induced dual synthetic lethality against HR-deficient leukemia cells.&lt;/p&gt;

10.1158/1541-7786.24229692.v1 preprint EN cc-by 2023-10-02
 Supplementary Figure 5 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S5. Targeting Polθ + PARP1 and RAD52 induced dual synthetic lethality against HR-deficient leukemia cells.&lt;/p&gt;

10.1158/1541-7786.24229692 preprint EN cc-by 2023-10-02
 Supplementary Figure 1 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S1. Genetic aberrations and mRNA expression variabilities of POLQ, PARP1 RAD52 do not coexist in 519 AML samples from the BEAT-AML cohort.&lt;/p&gt;

10.1158/1541-7786.24229704.v1 preprint EN cc-by 2023-10-02
 Supplementary Figure 2 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells
OPENALEX - Publications 
Katherine Sullivan-Reed Monika M. Toma Małgorzata Drzewiecka Margaret Nieborowska-Skorska Reza Nejati and 4 more Adam Karami Mariusz A. Wasik Tomasz Śliwiński Tomasz Skórski

&lt;p&gt;S2. Phenotype of Polq-/-;Parp1-/- and Polq-/-;Rad52-/- mice.&lt;/p&gt;

10.1158/1541-7786.24229701.v1 preprint EN cc-by 2023-10-02
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