A5101433495- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Peroxisome Proliferator-Activated Receptors
- Dermatology and Skin Diseases
- Renal and related cancers
- Urological Disorders and Treatments
- Studies on Chitinases and Chitosanases
- Psoriasis: Treatment and Pathogenesis
- Inflammatory mediators and NSAID effects
- Signaling Pathways in Disease
- Alzheimer's disease research and treatments
- Transgenic Plants and Applications
- Tissue Engineering and Regenerative Medicine
- Parathyroid Disorders and Treatments
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Cancer Immunotherapy and Biomarkers
- Parkinson's Disease Mechanisms and Treatments
- Reproductive System and Pregnancy
- Food Quality and Safety Studies
- Biopolymer Synthesis and Applications
- Cardiovascular Health and Disease Prevention
- Circadian rhythm and melatonin
- Estrogen and related hormone effects
Cell Biotech (South Korea)
2022-2024
Woosuk University
2024
Korea National University of Transportation
2021
Hanyang University
2015-2019
Abstract Central nervous system (CNS)-infiltrating effector T cells play critical roles in the development and progression of multiple sclerosis (MS). However, current drugs for MS are very limited due to difficulty delivering into CNS. Here we identify a cell-permeable peptide, dNP2, which efficiently delivers proteins mouse human cells, as well various tissues. Moreover, it enters brain tissue resident through blood vessels by penetrating tightly organized blood–brain barrier. The...
Abstract T cells generate antigen-specific immune responses to their cognate antigen as a hallmark of adaptive immunity. Despite the importance cells, here we show that non-related, bystander memory-like CD4 + also significantly contribute autoimmune pathogenesis. Transcriptome analysis demonstrates interleukin (IL)-1β- and IL-23-prime express pathogenic Η 17 signature genes such RORγt, CCR6, granulocyte macrophage colony-stimulating factor (GM-CSF). Importantly, when co-transferred with...
Abstract Peroxisome proliferator-activated receptor gamma (PPARγ), a master regulator of adipocyte differentiation, has recently been connected with effector T cells, though its role is still not clear. Here, we investigated the roles PPARγ in follicular helper (T FH ) cell responses regarding gender specificity. NP-OVA immunization female but male CD4-PPARγ KO mice induced higher proportions cells and germinal center (GC) B following than were seen wild type mice. Treatment agonist...
Peroxisome proliferator-activated receptor gamma (PPARγ) has recently been recognized to regulate adaptive immunity through Th17 differentiation, Treg functions, and TFH responses. However, its role in autoimmune disease is still not clear, possibly due sexual differences. Here, we investigated vitro treatment study with the PPARγ agonist pioglitazone compare Th1, Th2, differentiation male female mouse splenic T cells. Pioglitazone significantly inhibited various effector cell...
Estrogen receptor alpha (ERα) is a sex hormone nuclear that regulates various physiological events, including the immune response. Although there have been some recent studies on ERα regarding subsets of T cells, such as Th1, Th2, Th17, and Treg its role in follicular helper (TFH) cells has not yet elucidated. To determine whether controls TFH response antibody production, we generated cell-specific knockout (KO) mice by utilizing CD4-Cre/ERα flox system (CD4-ERα KO) then analyzed their...
NSCLC, the most common type of lung cancer, is often diagnosed late due to minimal early symptoms. Its high risk recurrence or metastasis post-chemotherapy makes DC-based immunotherapy a promising strategy, offering targeted cancer destruction, low side effects, memory formation, and overcoming immune evasive ability cancers. However, limited response DCs pulsed with single antigens remains significant challenge. To overcome this, we enhanced DC antigen presentation by pulsing TAAs. Our...
Renal fibrosis is an irreversible and progressive process that causes severe dysfunction in chronic kidney disease (CKD). The progression of CKD stages highly associated with a gradual reduction serum Klotho levels. We focused on protein as key therapeutic factor against CKD. Urine-derived stem cells (UDSCs) have been identified novel cell source for regeneration treatment because their tissue-specific origin. However, the relationship between UDSCs kidneys not yet known. In this study, we...
Abstract Background Urine-derived stem cells (UDSCs) can be easily isolated from urine and possess excellent cell characteristics, making them a promising source for therapeutics. Due to their kidney origin specificity, UDSCs are considered superior therapeutic alternative diseases compared other cells. To enhance the potential of UDSCs, we developed culture method that effectively boosts expression Klotho, kidney-protective factor. We also optimized Good Manufacturing Practice (GMP) system...
Abstract Regulatory T cells (Tregs) have critical roles for maintaining immune tolerance and homeostasis. Recently, it is revealed that CTLA-4 an essential membrane protein the suppressive function of Treg. However, molecular mechanism cytoplasmic domain (ctCTLA-4) its role in Treg differentiation not clearly understood. In this study, we utilized ctCTLA-4 peptide various mutant forms conjugated with dNP2, a cell-permeable peptide, to investigate differentiation. We found convert naïve...
Abstract Chitinase is evolutionary conserved enzyme that participated to regulation of parasite life cycle and anti-parasitic immune response. like protein, which lack a chitinase activity by mutations site also involved innate immunity, but their roles in T cell immunity has not been studied. Here, we investigated the role mouse CLP BRP-39 immunity. up-regulated naïve CD4 upon TcR stimuli. Although BRP-39-/- does have significant difference, cells showed increased production IL-2 IFN-γ with...
Abstract Atopic dermatitis and psoriasis are the two most common chronic inflammatory skin diseases with unmet needs. There still no effective safe topical therapeutics for current developing biologics have limitation of administration methods. Here, we identified a novel transdermal delivery peptide (AP) generated engineered immunomodulatory protein to inhibit dermatitis. AP-conjugated proteins exhibited significant intracellular transduction efficacy in keratinocytes, fibroblasts, immune...
Abstract Antigen-nonspecific bystander activation of CD4+ T lymphocytes have been recently discovered. However, the immunopathological role non-specific activated cells responding to pro-inflammatory cytokines remains unknown. Here, we show that IL-1β acted directly on polyclonal memory, but not naïve, in synergy with IL-23 promote IL-17A and IFN-γ expression both mice human. This cell is dependent IL-1 antigen receptors (TCRs). In vivo, co-transfer MOG-specific TCR transgenic (2D2) naïve...
Kimchi is an unpasteurized product and thus yeasts could easily grow on it during transportation storage. In particular, the growth of white colony-forming (WCFY) become a major concern at export market due to long period. Thus, aim this study was evaluate inhibitory effect chitosan WCFY in broth study, Kazachstania servazzii, Pichia kudriavzevii Hanseniaspora uvarum isolated from or red paper powder were used. Each yeast species inoculated YPD containing 1.0% dissolved with lactic acid,...