A5100333371- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Click Chemistry and Applications
- Ubiquitin and proteasome pathways
- Advanced Fluorescence Microscopy Techniques
- Biofuel production and bioconversion
- Peptidase Inhibition and Analysis
- Nicotinic Acetylcholine Receptors Study
- Sphingolipid Metabolism and Signaling
- Endometriosis Research and Treatment
- Lipid Membrane Structure and Behavior
- Protein Kinase Regulation and GTPase Signaling
- Ion channel regulation and function
- Global Energy Security and Policy
- Anaerobic Digestion and Biogas Production
- Receptor Mechanisms and Signaling
- Venomous Animal Envenomation and Studies
- Chemical Synthesis and Analysis
- Ion Transport and Channel Regulation
- Drug Transport and Resistance Mechanisms
- Global Energy and Sustainability Research
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Zebrafish Biomedical Research Applications
- Market Dynamics and Volatility
Fujian Medical University
2024-2025
Southern University of Science and Technology
2023-2024
Ocean University of China
2022-2024
Vanderbilt University
2023
Hunan Normal University
2020
Weifang Medical University
2019
AMG510, as the first approved inhibitor for KRASG12C mutation, has shown promising efficacy in nonsmall-cell lung cancer and colorectal harboring mutation. However, moderate response rate rapid emergence of acquired resistance limit therapeutic potential highlighting need development combination strategies. Here, we observed suppression RAS-MAPK signaling induced by AMG510 was prolonged enhanced SOS1 knockdown. Thus, design, synthesize, characterize a potent specific degrader 23. Compound 23...
The solute carrier 13 (SLC13) family comprises electrogenic sodium ion-coupled anion cotransporters, segregating into ion-sulfate cotransporters (NaSs) and ion-di- and-tricarboxylate (NaDCs). NaS1 NaDC1 regulate sulfate homeostasis oxidative metabolism, respectively. deficiency affects murine growth fertility, while urinary citrate calcium nephrolithiasis. Despite their importance, the mechanisms of substrate recognition transport remain insufficiently characterized. In this study, we...
Sphingosine (Sph) plays important roles in various complex biological processes. Abnormalities Sph metabolism can result diseases, including neurodegenerative disorders. However, due to the lack of rapid and accurate detection methods, understanding sph metabolic related diseases is limited. Herein, a series near-infrared fluorogenic probes DMS-X (X = 2F, F, Cl, Br, I) are designed synthesized. The fast oxazolidinone ring formation enables DMS-2F detect selectively ultrasensitively, limit...
Histone deacetylases (HDACs) are validated targets for the development of anticancer drugs in epigenetics. In discovery novel HDAC inhibitors with potency, 5-chloro-4-((substituted phenyl)amino)pyrimidine fragment is assembled as a cap group into structure inhibitors. The SAR revealed that presence small groups (such methoxy substitution) beneficial inhibitory activity. enzyme selectivity test, compound L20 exhibited class I IC50 values 0.684 µM (selectivity index >1462), 2.548 >392), and...
Sodium channels play a critical role in the generation and propagation of action potentials excitable tissues, such as nerves, cardiac muscle, skeletal are primary targets toxins found animal venoms. Here, two novel peptide (Cl6a Cl6b) were isolated from venom spider Cyriopagopus longipes characterized. Cl6a Cl6b shown to be inhibitors tetrodotoxin-sensitive (TTX-S), but not TTX-resistant, sodium channels. Among TTX-S investigated, showed highest degree inhibition against NaV1.7...
<title>Abstract</title> The stability of fluorescent proteins (FPs) is crucial for many imaging techniques, including long-term live cell imaging, correlative light and electron microscopy (CLEM), tissue clearing. While several stable green yellow FPs exist, the options monomeric red (RFPs), commonly used as spectral counterparts dual-color are significantly limited. Here, we applied structure-guided mutagenesis to develop an extremely RFP named mYongHong report its structure at 1.5 Å...
Endometriosis (EMS) is a chronic inflammatory disease frequently associated with infertility. N6-methyladenosine (m6A) methylation, the most common form of methylation in eukaryotic mRNAs, has gained attention study female reproductive diseases, including EMS and This aimed to investigate role m6A regulators EMS-related To begin, specific were identified by analyzing GSE120103 dataset, followed receiver operating characteristic (ROC) curve analysis. A nomogram model was then constructed,...
Inhibition of histone deacetylases (HDACs) has been an important emerging therapy for the treatment multiple cancers. However, application HDAC inhibitors is restricted by limited potency against solid tumors. In order to discover novel with potent antitumor activities, nitrogen mustard group was introduced structure CI994. The derived molecule