A5101867214- Advanced Fluorescence Microscopy Techniques
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Hypothalamic control of reproductive hormones
- Glycosylation and Glycoproteins Research
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Hepatitis B Virus Studies
- Traditional and Medicinal Uses of Annonaceae
- Protease and Inhibitor Mechanisms
- Ubiquitin and proteasome pathways
- Lipid metabolism and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive System and Pregnancy
- Hepatitis C virus research
- Cancer Mechanisms and Therapy
- Carbohydrate Chemistry and Synthesis
- Assisted Reproductive Technology and Twin Pregnancy
- Sirtuins and Resveratrol in Medicine
- Parkinson's Disease Mechanisms and Treatments
- Cellular transport and secretion
- Reproductive Health and Contraception
- Neurological disorders and treatments
Wuhan University of Science and Technology
2020-2025
Fudan University
2018-2024
ShangHai JiAi Genetics & IVF Institute
2024
University of South China
2024
Southern Medical University
2023-2024
Nanfang Hospital
2023-2024
Shanghai Jiao Tong University
2021-2024
Kunming Children's Hospital
2023
Shantou Central Hospital
2020-2022
Zunyi Medical University
2021
Abstract Background Obesity has been linked to an increased risk of female infertility. Leptin, adipocytokine which is elevated during obesity, may influence gonadal function through modulating steroidogenesis in granulosa cells. Methods The effect leptin on progesterone production simian virus 40 immortalized (SVOG) cells was examined by Enzyme immunosorbent assay (ELISA). the expression steroidogenic enzymes (StAR, P450scc, 3betaHSD) SVOG real-time PCR and Western blotting. mRNA receptor...
Protein tyrosine kinase-7 (PTK7) has been reported as a vital participant in the Wnt signaling pathway, influencing tumorigenesis and metastasis. However, their specific roles mechanisms underlying cancer development progression remain elusive. Here, using direct stochastic optical reconstruction microscopy (dSTORM) with aptamer-probe labeling, we first revealed that weakening clustering distribution of PTK7 on basal membranes happened cellular migration increased during progression. This...
Abstract Background Ovarian granulosa cells are the predominant source of estradiol and progesterone biosynthesis in vivo. Rosiglitazone, a synthetic agonist peroxisome proliferator-activated receptor gamma (PPAR gamma), is applied as treatment insulin resistance including women with PCOS. The aim study was to investigate direct effects rosiglitazone on steroidogenesis proinflammatory factor production human granulosa-lutein (GLCs). Methods Primary GLCs were separated during vitro...
A stereoselective synthesis of the biologically interesting γ-monofluorinated goniothalamin analogue 2a was described. The features included regioselective reduction unprotected hydroxypropynyl moiety compound 10 by Red-Al, asymmetric Sharpless epoxidation allyl alcohol 11, and regio- ring-opening hydrofluorination epoxide 14 with Et3N·3HF in high ee dr. chiral fluorohydrin 15 used as a valuable building block for preparation range α,β-unsaturated δ-lactones.
Objectives We employed quantitative susceptibility mapping (QSM) to assess iron deposition in parkinsonian disorders and explored whether combining QSM values neurofilament light (NfL) chain levels can improve the accuracy of distinguishing Parkinson’s disease (PD) from multiple system atrophy (MSA) progressive supranuclear palsy (PSP). Materials methods Forty-seven patients with PD, 28 MSA, 18 PSP, healthy controls (HC) were enrolled, data reconstructed. Susceptibility bilateral globus...
Spinal cord injuries (SCIs) often result in limited prospects for recovery and a high incidence of disability. Melatonin (Mel), hormone, is acknowledged its neuroprotective attributes. Mel was examined this study to discover if it alleviates SCIs via the sirtuin1/dynamin-related protein1 (SIRT1/Drp1) signaling pathway. were simulated mice by inducing contusion at T9–T10 vertebrae causing inflammation primary spinal neurons using lipopolysaccharide (LPS). The findings our demonstrated that...
Background: Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder with various subtypes and uncertain pathogenesis. Iron deposition considered to be involved in the pathological mechanisms of PD. The present study aimed investigate iron deep gray matter patients different PD using quantitative susceptibility mapping (QSM). Methods: Forty-six 22 healthy controls (HCs) were recruited for study. allocated tremor-dominant (TD) group (n=22), postural instability gait...
Exploiting small-molecule inhibitor-based fluorescent probes benefits obtaining a more accurate distribution of targets by super-resolution fluorescence imaging.
Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role development and invasion of tumours. It was recently discovered that ENPP3 upregulated during window implantation endometrium but its functional relevance remains elusive. The objective determine expression roles endometrial receptivity embryo implantation. analysed using immunohistochemistry western blot assay. effects on were evaluated BeWo cell (a...
Abstract STUDY QUESTION Is there any difference in the ongoing pregnancy rate after immediate versus delayed frozen embryo transfer (FET) following a stimulated IVF cycle? SUMMARY ANSWER Immediate FET cycle produced significantly higher and live birth than did FET. WHAT IS KNOWN ALREADY Embryo cryopreservation is an increasingly important part of IVF, but still no good evidence to advise when perform cycle. All published studies are retrospective, findings contradictory. DESIGN, SIZE,...
The relationship between chronic hepatitis B (CHB) and Coronavirus disease 2019 (COVID-19) has been inconsistent in traditional observational studies.We explored the total causal direct associations CHB three COVID-19 outcomes using univariate multivariate Mendelian randomization (MR) analyses, respectively. Genome-wide association study datasets for were obtained from Japan Biobank Host Genetics Initiative, respectively.Univariate MR analysis showed that increased risk of SARS-CoV-2...
Cancer stem cells (CSCs) contribute to therapy resistance in HCC. Linear ubiquitin chain assembly complex (LUBAC) has been reported accelerate the progression of cancers, yet its role sorafenib response HCC is poorly defined. Herein, we investigated impact LUBAC on and CSC properties HCC, explored potential targeted drugs.
Introduction Progestin can inhibit the pituitary luteinising hormone (LH) surge during ovarian stimulation for in vitro fertilisation (IVF) and studies show progestin-primed (PPOS) is effective blocking LH IVF. More more centres are using PPOS because this regimen appears simpler cheaper. This study aims to compare euploidy rate of blastocysts following protocol gonadotropin-releasing antagonist women undergoing preimplantation genetic testing aneuploidy (PGT-A). Methods/analysis a...
Introduction In recent years, the use of frozen embryo transfers (FET) has rapidly increased following freeze-all strategy due to advantages maternal safety, improved pregnancy rates, lower ectopic rates and better obstetric neonatal outcomes. Currently, there is still no good scientific evidence support when perform FET a stimulated in vitro fertilisation (IVF) cycle strategy. Methods/analysis This will be randomised controlled trial. A total 828 women undergoing their first IVF enrolled...
Estrogen receptors (ERs) are activated by their ligands as well signaling pathways that alter ER phosphorylation in response to peptide hormones and growth factors. In pituitary gonadotrophs, GnRHs act via the type I GnRH receptor (GnRHR). Both subtypes (GnRH-I -II) activate an estrogen element (ERE)-driven luciferase reporter gene LbetaT2 mouse cells, GnRH-I is most potent this regard. Moreover, antide (a antagonist) a GnRHR small interfering RNA (siRNA) abrogate effect, whereas ERalpha...