F. J. Kessler

ORCID: 0009-0009-9084-3549
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About
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Research Areas
  • Parathyroid Disorders and Treatments
  • Cardiovascular and Diving-Related Complications
  • Thyroid Disorders and Treatments
  • Magnesium in Health and Disease
  • High Altitude and Hypoxia
  • Chemical Analysis and Environmental Impact
  • Renal function and acid-base balance
  • Respiratory Support and Mechanisms
  • Sympathectomy and Hyperhidrosis Treatments
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Biomedical Research and Pathophysiology
  • Renal and Vascular Pathologies
  • Lung Cancer Research Studies
  • Menopause: Health Impacts and Treatments
  • Genetic Syndromes and Imprinting
  • Ion Transport and Channel Regulation
  • Non-Invasive Vital Sign Monitoring
  • Trauma Management and Diagnosis
  • Trauma and Emergency Care Studies
  • Thyroid Cancer Diagnosis and Treatment
  • Effects of Radiation Exposure
  • Muscle and Compartmental Disorders
  • Hormonal and reproductive studies
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Shoulder and Clavicle Injuries

University of Zurich
2025

University Hospital Frankfurt
2025

Goethe University Frankfurt
2025

University Hospital of Zurich
2025

University Hospital Bonn
1961-2016

University of Bonn
2014

Eli Lilly (Germany)
2004-2006

Abstract Purpose Removal of symptomatic hardware after fracture fixation is common, especially in patients with clavicle fracture. Yet, refracture removal a relatively common complication those patients. The aim this study was to identify risk factors for refractures that could be influenced by the surgical treatment provided. Methods All from level one trauma center 2017 2022 were screened eligibility. Inclusion criteria included plate osteosynthesis clavicle, age ≥ 18 years, and signed...

10.1007/s00068-025-02794-x article EN cc-by European Journal of Trauma and Emergency Surgery 2025-02-21

Numerous studies have investigated variables that predict mortality and complications following severe trauma. These studies, however, mainly focus on admission values or a single variable. The aim of this study was to investigate the predictive quality multiple routine clinical measurements (at in ICU). Retrospective cohort severely injured patients treated at one Level 1 academic trauma centre. injury (ISS ≥ 16 points), primary complete data set. Exclusion criteria end-of-life treatment...

10.1186/s40001-025-02477-8 article EN cc-by-nc-nd European journal of medical research 2025-04-02
Simon Howell Sanne E. Hoeks Robert West Stephen G. Wheatcroft Andreas Hoeft and 95 more B. Leva B. Plichon Sabrine Damster Mona Momeni Christine Watremez D. Kahn Anne-Sophie Dincq A. Danila Mária Wittmann Rafael Struck T. Rüddel F. J. Kessler Stefan Rasche Paraskevi Matsota Antigona Hasani Jūratė Gudaitytė Aurika Karbonskienė Rafael Meneguzzi Alves Ferreira Susana Carvalho Dana Tomescu C. Martac I. Grintescu Lucia Mirea Leyre Serrano Fernández Leyre Serrano Fernández P. Sierra Sergi Sabaté David Hernando P. Matute M. Trashorras M. Suñé L Argüello Adriana Hervías Óscar González‐Lorenzo Andrew Hermina Óscar González‐Lorenzo Andrew Hermina R. Perez María Isabel Orts Raquel Fernández García D. Sánchez Pérez I. Sepulveda Gil Pablo Monedero Francisco Hidalgo C. Mbongo A. Rodríguez Hugo Reyes Carlos Bártolo S López Galera Tabita M. Valentijn Robert Jan Stolker Mehmet Tuğrul Ebru-Berrin Demirel M. Hough K. Griffiths Stephen Birch Z. Beardow S. Elliot Jonathan P. Thompson Sarah Bowrey Martin Northey H. Melson Richard J. Telford Maria Nadolski A. Potter Daniela T. Fuller Adam J. Rose S. Varma Karen Simeson Joshua Pettit Nicola Jayne Smith Victoria Martinson Lisa Sleight C. David Naylor P. R. Watt Parizade Raymode Nigel Dunk Linda Twohey Laszlo Hollos Simon Davies Andrew K. Gibson Zoe Coleman Tamm Ti J. Joscak Lajos Zsisku M. Zuleika P. Carvalho T. Collyer Jason Ryan Kristin P. Colling S. Dharmarajah Anand Muthu Krishnan Jonathan Paddle Anna Fouracres Kai Arnell

BackgroundThe perioperative management of antiplatelet therapy in noncardiac surgery patients who have undergone previous percutaneous coronary intervention (PCI) remains a dilemma. Continuing dual (DAPT) may carry risk bleeding, while stopping increase the major adverse cardiovascular events (MACE).MethodsOccurrence Bleeding and Thrombosis during Antiplatelet Therapy In Non-Cardiac Surgery (OBTAIN) was an international prospective multicentre cohort study treatment, MACE, serious bleeding...

10.1016/j.bja.2018.09.029 article EN cc-by-nc-nd British Journal of Anaesthesia 2018-12-15

Prolonged breath-hold causes complex compensatory mechanisms such as increase in blood pressure, redistribution of flow, and bradycardia. We tested whether apnea induces an elevation catecholamine-concentrations well-trained apneic divers.11 divers performed maximal dry a horizontal position. Parameters measured during included ECG, central, addition to peripheral hemoglobin oxygenation. Peripheral arterial oxygenation was detected by pulse oximetry, whereas (abdominal) central (cerebral)...

10.1055/s-0042-107351 article EN International Journal of Sports Medicine 2016-07-25

Objective: To assess the prevalence of skeletal pain in postmenopausal women before onset raloxifene treatment and further course during a naturalistic setting.Research design methods: Prospective, uncontrolled, multicentre, 6‐month, observational study Germany. Clinical, diagnostic data were collected at baseline, 6 weeks months from 3299 female outpatients with osteoporosis. Physicians assessed presence or absence back pain, joint diffuse bone each visit, perceived sleep quality use...

10.1185/030079906x154097 article EN Current Medical Research and Opinion 2006-10-30

Following the third operation, aparathyroidism occurred in a 70-year-old female with primary hyperparathyroidism due to parathyroid hyperplasia. Part of obtained during last operation was cryopreserved immediately after resection and replanted successfully 15 days into lower arm muscles. The function transplanted tissue demonstrated by successful stepwise reduction hormone substitution. Parathyroid concentrations blood veins draining were more than double comparison contralateral side....

10.1055/s-2008-1070318 article EN DMW - Deutsche Medizinische Wochenschrift 2008-03-26

Recurrent hypovolaemic shock had been occurring over the last five and four years, respectively, in a 53-year-old woman 46-year-old man who previously healthy. The attacks were characterized by tension feeling sometimes oedema limbs, as well increased thirst. Within few hours sweating, tachycardia, orthostatic complaints would occur. woman's systolic blood pressure fall to 70 mm Hg pulse rate rise 150/min. man's was not measurable sphygmomanometer during his first attack. Haematocrit rose 61...

10.1055/s-2008-1065195 article EN DMW - Deutsche Medizinische Wochenschrift 2008-03-25

1. Bei mit Kaliumperchlorat vorbehandelten Ratten bewirken Trijodthyronin und Thyroxin in einem Dosisbereich von 1–25μ g/100 g Ratte nach 10 Tagen eine dosisabhangige Hemmung der Strumabildung. 2. Die gleichzeitig eintretende morphologische Stimulierung Nebennierenrinde geht stoffwechselsteigernden Wirkung Schilddrusenhormone, nicht deren Schilddrusenhemmung parallel. 3. Die sich aus diesen Befunden ergebenden Folgerungen zum Problem funktionellen Beziehungen...

10.1007/bf02046283 article DE Zeitschrift für die Gesamte Experimentelle Medizin 1961-01-01

Wistarratten erhielten 8 Tage lang physiologische Kochsalzlösung, L-Trijodthyronin, Kaliumperchlorat oder Dihydrotachysterin. An Paraffinschnitten der Schilddrüse wurden die Kerngrößen Follikelepithelien und C-Zellen bestimmt. Im Vergleich zur Behandlung mit NaCl vermindert Gabe von L-Trijodthyronin Kerngröße sowohl als auch C-Zellen, bei letzteren aber in geringerem Umfang. Umgekehrt wie Wirkung waren Effekte unter Kaliumperchlorat. Dihydrotachysterin-Belastung hat nur eine morphometrisch...

10.1007/bf02045980 article DE Zeitschrift für die Gesamte Experimentelle Medizin 1971-05-01

In 1975, scintigraphy revealed a 6.5 x 5 cm tumour in the region of left adrenal 36-year-old man with known hypertension for years (systolic pressure up to 250 mm Hg, diastolic 130 Hg). A laparotomy was performed suspected phaeochromocytoma. located upper pole kidney and removed together kidney. The blood quickly returned normal after operation: it remained stable following 17 (between 130/80 150/90 Originally could not be clearly classified either clinically or histologically. But recently...

10.1055/s-2008-1059433 article EN DMW - Deutsche Medizinische Wochenschrift 2008-03-25

In case of apnea, arterial partial pressure oxygen (pO2) decreases, while carbon dioxide (pCO2) increases. To avoid damage to hypoxia sensitive organs such as the brain, compensatory circulatory mechanisms help maintain an adequate supply. This is mainly achieved by increased cerebral blood flow. Intermittent a commonly seen phenomenon in patients with obstructive sleep apnea. Acute airway obstruction can also result and hypercapnia. Until now, no model has been established simulate these...

10.3791/54933 article EN Journal of Visualized Experiments 2016-12-22

In case of apnea, arterial partial pressure oxygen (pO2) decreases, while carbon dioxide (pCO2) increases. To avoid damage to hypoxia sensitive organs such as the brain, compensatory circulatory mechanisms help maintain an adequate supply. This is mainly achieved by increased cerebral blood flow. Intermittent a commonly seen phenomenon in patients with obstructive sleep apnea. Acute airway obstruction can also result and hypercapnia. Until now, no model has been established simulate these...

10.3791/54933-v article EN Journal of Visualized Experiments 2016-12-22

ABSTRACT 1. Reserpine does not inhibit the tissue respiration of liver in normal male rats (in vitro). 2. The decrease with simultaneous morphological stimulation thyroid gland after long administration reserpine is due to a minute inhibition hormone synthesis gland. 3. alterations experimental hypothyroidism perchlorate can be prevented reserpine.

10.1530/acta.0.0390423 article EN European Journal of Endocrinology 1962-03-01

Hintergrund: In dieser Anwendungsbeobachtung („Gemcitabin Onkologische Lilly Deutschland”, GOAL) wurde untersucht, wie Ärzte Gemcitabin (Gemzar®) im Praxisalltag zur First-line-Therapie des fortgeschrittenen nichtkleinzelligen Bronchialkarzinoms (NSCLC) und Pankreaskarzinoms (PaC) einsetzen. Ziel war herauszufinden, evidenzbasierte Therapieempfehlungen umgesetzt werden. Methodik: Zwischen November 2001 September 2002 dokumentierten 111 Klinik- niedergelassene in Deutschland prospektive Daten...

10.1055/s-2004-813486 article DE TumorDiagnostik & Therapie 2004-10-01

Zusammenfassung Bei einer Ganzkörperbestrahlung weißer Wistarratten mit 1000 r tritt nach 72 Stunden eine Aktivitätszunahme der Blutgerinnungsfaktoren Prothrombin, Faktor V und VII, ein. Erhöht man die Strahlendosis auf das Zehnfache, wird Faktorenanstieg bereits 48 beobachtet. Diese Dosisabhängigkeit besteht nur in zeitlicher, nicht quantitativer Hinsicht. milzexstirpierten Tieren ist Bestrahlung ein gleichartiges Verhalten Gerinnungsfaktoren festzustellen. Den größten Aktivitätszuwachs...

10.1055/s-0038-1654820 article DE Thrombosis and Haemostasis 1964-01-01
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