A5015421695- Tryptophan and brain disorders
- Posttraumatic Stress Disorder Research
- Stress Responses and Cortisol
- Metabolism and Genetic Disorders
- Psychosomatic Disorders and Their Treatments
- Neuropeptides and Animal Physiology
- Health, psychology, and well-being
- Suicide and Self-Harm Studies
- Sleep and Wakefulness Research
- Health and Wellbeing Research
- Diet and metabolism studies
- Viral Infections and Immunology Research
- Parkinson's Disease Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Alcoholism and Thiamine Deficiency
- Adipose Tissue and Metabolism
- Cardiac Health and Mental Health
- Migration, Health and Trauma
- Receptor Mechanisms and Signaling
- Mental Health Treatment and Access
- Obesity, Physical Activity, Diet
- Viral gastroenteritis research and epidemiology
- Child and Adolescent Psychosocial and Emotional Development
- Childhood Cancer Survivors' Quality of Life
- Workplace Health and Well-being
Kishokai Medical Corporation
2014-2025
Kawamura Hospital
2017
Kyushu University
2000-2011
National Center of Neurology and Psychiatry
1996-2010
National Institute of Mental Health
1998-2010
Kagoshima University
2009
Ministry of Health Labour and Welfare
2004
Ministry of Education, Culture, Sports, Science and Technology
2004
National Cancer Center Hospital East
2002
Institute of Mental Health
2002
The authors developed the Japanese-language version of Impact Event Scale-Revised (IES-R-J) and investigated its reliability validity in four different groups: workers with lifetime mixed traumatic events, survivors an arsenic poisoning case, Hanshin-Awaji earthquake, Tokyo Metro sarin attack. Evidence includes retest internal consistency IES-R-J. Posttraumatic stress disorder (PTSD) partial PTSD cases indicated significantly higher scores than non-PTSD cases. IES-R-J can be a useful...
A number of recombinants between the virulent Mahoney and attenuated Sabin strains type 1 poliovirus were constructed by using infectious cDNA clones two strains. To identify a strong neurovirulence determinant(s) residing in genome region upstream nucleotide position 1122, these recombinant viruses subjected to biological tests, including monkey tests. The results tests suggested important contribution an adenine residue (Mahoney type) at 480 expression phenotype poliovirus. This...
OBJECTIVE: High rates of medical morbidity have been reported in subjects with posttraumatic stress disorder (PTSD). The authors examined immune function remission from past PTSD. METHOD: initial study group was composed 1,550 Japanese male workers. versions the Events Check List, Impact Event Scale—Revised, and Diagnostic Interview Schedule for DSM-IV were used to identify who had a history Twelve workers identified as having such history. These men matched age smoking habits, which affect...
Aims: To evaluate effects of exposure to bisphenol A diglycidyl ether (BADGE) on urinary excretion A, and plasma gonadotrophic hormones testosterone in male epoxy resin sprayers. Methods: Cross sectional study 42 workers whose job was spray hardening agents including BADGE mixed organic solvents, matched control without use the same machine plants. Results: Concentrations were higher sprayers (median 1.06 μmol/mol creatinine) compared with controls 0.52 creatinine). Urinary metabolite...
antioxidant vitamins are expected to protect cells from oxidative damage by neutralizing the effects of reactive oxygen species. However, epidemiological evidence regarding associations between vitamin intake and Parkinson's disease (PD) is limited inconsistent. We investigated relationship dietary selected vitamins, vegetables fruit risk PD in Japan using data a multicenter hospital-based case-control study.included were 249 patients within 6 years onset PD. Controls 368 inpatients...
Coping strategies may be significantly associated with health outcomes. This is the first study to investigate association between baseline coping and cardiovascular disease (CVD) incidence mortality in a general population cohort. The Japan Public Health Center-based prospective Study asked questions on its third follow-up survey (2000–04). Analyses CVD included 57 017 subjects aged 50–79 without history of who provided complete answers approach- avoidance-oriented behaviours strategies....
Though immune outcome is known to be determined by which helper T cell response predominates, no local mechanism has yet been established can explain how the neuronal system may control this. It possible that nervous releases neuropeptides at specific sites of infection or challenge, triggers lymphocytes those points release cytokine profiles. These then influence direction Th1/Th2 and therefore outcome. The aim this study was evaluate whether if so production lymphocytes, especially cells....
Poliovirus exists as three stable serotypes (PV-1, PV-2, and PV-3). These viruses display antigenic sites each, designated N-AgI, N-AgII, N-AgIII. When mice are immunized with poliovirus, N-AgI is the major neutralization site for PV-3, whereas N-AgII N-AgIII immunodominant over PV-1. To study relationship between structure antigenicity, a hybrid virus was constructed in which of PV-1 replaced by PV-3. PV-3- PV-1-specific antisera, including those elicited PV-3 primates, neutralized virus....
Background: Nearly all epidemiologic studies examining the association between risk of Parkinson’s disease (PD) and diet have focused on single foods specific nutrients. However, evidence for dietary pattern with PD, namely measurement overall by considering cumulative effects nutrients is extremely limited. We conducted a hospital‐based case–control study in Japan to examine relationship patterns PD. Methods: Patients PD diagnosed using UK Society Brain Bank criteria ( n = 249) controls...
This study sought to characterize the plasma metabolite profiling of patients with major depressive disorder (MDD).Psychiatric assessments were made Structured Clinical Interview for DSM-IV Axis I Disorders. In exploratory cohort, profiles 34 MDD and 31 mentally healthy controls compared using capillary electrophoresis-mass spectrometry. Among candidate metabolites, we focused on a showing largest difference. The absolute concentrations measured in two cohorts from psychiatric primary care...
Abstract Prior studies have revealed that the sympathetic nervous system regulates clinical and pathological manifestations of experimental autoimmune encephalomyelitis (EAE), an disease model mediated by Th1 T cells. Although regulatory role catecholamines has been indicated in previous works, it remained possible other neurotransmitters like neuropeptide Y (NPY) may also be involved regulation EAE. Here we examined effect NPY receptor subtype-specific compounds on EAE, actively induced...
Insomnia is associated with physical and mental disorders. We examined the effect of insomnia on immune functions, focusing T helper 1 (Th1)/ 2 (Th2) balance, by a cross-sectional design.We provided self-administered questionnaire to evaluate sleep habits, smoking medical disorders 578 men without any toxic exposure (20-64 years old), measured natural killer (NK) cell activity in 324 production interferon-gamma (IFN-gamma) interleukin-4 (IL-4) after stimulation phytohemagglutinin 254 men....
An insertion sequence of 72 nucleotides prepared from a polylinker plasmid pUC18 was introduced at nucleotide position 702 the 5' noncoding (742 long) genome Sabin strain poliovirus type 1 by using an infectious cDNA clone virus strain. The mutant thus obtained showed small-plaque phenotype compared with that parent virus. Apparent revertants (large-plaque variants) were easily generated mutant. Nucleotide analysis performed on revertant genomes to determine mutation(s) which plaque size...
Background Although there is speculation that individuals living in the vicinity of nuclear disasters have persistent mental health deterioration due to psychological stress, few attempts been made examine this issue. Aims To determine whether having Nagasaki atomic bomb explosion absence substantial exposure radiation affected local inhabitants more than half a century later. Method Participants were randomly recruited from who lived uncontaminated suburbs Nagasaki. This sample ( n = 347)...
Abstract Background We have reported that plasma phosphoethanolamine (PEA) concentration is a candidate biomarker of depressive disorder (1). Aims & Objectives To characterize this marker and investigate its clinical usefulness, we carried out an observational study while respecting the subjects' freedom to participate in study. Method Psychiatric assessments were made with Structured Clinical Interview for DSM-5. The absolute concentrations PEA samples from psychiatric primary care...
We examined the influences of perceived parental bonding on scores alexithymia in a sample 232 college students. Ratings mothers' care, scale Parental Bonding Inventory were significantly and negatively correlated with Toronto Alexithymia Scale, also ratings Difficulty Describing Feelings but not Identifying Externally Oriented Thinking. These results replicated another 156 Although our findings based simple correlations, they suggest that low care is related to adults' alexithymia,...
Alexithymia is a psychological trait characterized by difficulty in verbalizing feelings, which has been associated with number of illnesses, including bronchial asthma and cancer.In order to understand how variables such as alexithymia affect physical health, we compared the lymphocyte subsets men (n = 97, mean 30.6) rated high low alexithymic when measured Toronto Scale (TAS). We analyzed our data considering categorical variable, using TAS scores 62 below, 74 above, continuous score...
Abstract Particulate‐filled thermosetting composites are widely used, yet little systematic work has been done on their long‐term strength characteristics. In this study short‐term tensile, flexural, and impact tests as well tensile creep‐rupture were made for unfilled filled epoxy to clarify the effects of filler size, content, temperature. Fillers used silica, alumina particles, glass beads. Test temperatures varied from 25 110°C. As a result testing, it was found that Petch relation held...
Tanaka K, Miyake Y, Fukushima W, Sasaki S, Kiyohara C, Tsuboi Yamada T, Oeda Miki Kawamura N, Sakae Fukuyama H, Hirota Nagai M, the Fukuoka Kinki Parkinson’s disease Study Group. Active and passive smoking risk of disease.Acta Neurol Scand: 2010: 122: 377–382.© 2010 The Authors Journal compilation © Blackwell Munksgaard. Objective – To assess association between active (PD), a case–control study with 249 PD patients 369 controls was carried out in Japan. Methods Information on obtained...