A5087420912- Carbohydrate Chemistry and Synthesis
- Effects and risks of endocrine disrupting chemicals
- Glycosylation and Glycoproteins Research
- Parathyroid Disorders and Treatments
- Natural product bioactivities and synthesis
- Analytical Chemistry and Chromatography
- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Estrogen and related hormone effects
- Injury Epidemiology and Prevention
- Phytochemistry and Biological Activities
- Genetic Syndromes and Imprinting
- HIV/AIDS drug development and treatment
- Forensic and Genetic Research
- Enzyme Production and Characterization
- Toxic Organic Pollutants Impact
- Sesquiterpenes and Asteraceae Studies
- Amino Acid Enzymes and Metabolism
- Metabolism, Diabetes, and Cancer
- Biochemical and Molecular Research
- Retinoids in leukemia and cellular processes
- Enzyme Catalysis and Immobilization
- Molecular Biology Techniques and Applications
Nihon University
2012-2022
Jikei University School of Medicine
2016-2020
Miyazaki Prefectural Hospital
2000-2012
University of Miyazaki
1996-2012
University of Alberta
1996-2003
Daiichi-Sankyo (Japan)
2003
Duke University Hospital
2003
Duke Medical Center
2003
Showa Pharmaceutical University
2002
Hamamatsu University
2001
UDP-3-<i>O</i>-(<i>R</i>-3-hydroxymyristoyl)-<i>N</i>-acetylglucosamine deacetylase (LpxC) catalyzes the second step in biosynthesis of lipid A, a unique amphiphilic molecule found outer membranes virtually all Gram-negative bacteria. Since A is required for bacterial growth, inhibitors LpxC have potential utility as antibiotics. The enzymes biosynthesis, including LpxC, are encoded by single copy genes sequenced genomes. We now cloned, overexpressed, and purified from hyperthermophile...
Adiponectin is a cytokine secreted from adipocytes and regulates metabolism. Although serum adiponectin levels show diurnal variations, it not clear if the effects of are time-dependent. Therefore, this study conducted locomotor activity analyses various metabolic studies using knockout (APN (-/-)) APN (+/+) mice to understand whether circadian rhythm glucose lipid We observed that gene deficiency does affect rhythmicity core clock genes expression in several peripheral tissues. In contrast,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesign and Synthesis of Sialyl Lewis X MimeticsTaketo Uchiyama, Vassil P. Vassilev, Tetsuya Kajimoto, Weichyun Wong, Chun-Cheng Lin, Hongmei Huang, Chi-Huey WongCite this: J. Am. Chem. Soc. 1995, 117, 19, 5395–5396Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 1995https://doi.org/10.1021/ja00124a037RIGHTS & PERMISSIONSArticle Views467Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views...
Neuroblastoma is among the most fatal of solid tumors in pediatric age group, even when treated aggressively. Therefore, a new effective therapeutic drug(s) for neuroblastoma urgently needed. To clarify anticancer effects sesquiterpene lactones dehydrocostus lactone and costunolide, derived from Saussurea lappa, we examined cytotoxic migration/invasion-inhibitory these compounds against cell lines. Both exerted significant cytotoxicity lines IMR-32, NB-39, SK-N-SH, LA-N-1. Evidence cellular...
Glial cells missing homolog 2 (GCM2), a zinc finger-type transcription factor, is essential for the development of parathyroid glands. It considered to be master regulator because glands do not form when Gcm2 deficient. Remarkably, expression maintained throughout fetal stage and after birth. Considering function in embryonic stages, it predicted that maintains cell differentiation survival adults. However, there lack research regarding adulthood. Therefore, we analyzed adult...
The enzyme LpxC (UDP-3-O-[(R)-3-hydroxymyristoyl]-GlcNAc deacetylase) catalyzes the second step of lipid A biosynthesis and is essential for bacterial growth. GlcNAc-derived hydroxamic acid inhibitor 8 this was synthesized using two different routes. Compound exhibits activity toward enzymes from a wider spectrum species than any previously reported inhibitors.
Brain and muscle arnt-like protein 1 (BMAL1), is a transcription factor known to regulate circadian rhythm. BMAL1 was originally characterized by its high expression in the skeletal muscle. Since dominant organ system energy metabolism, possible functions of include control metabolism. Here, we established that involvement regulation oxidative capacity Muscle-specific Bmal1 KO mice (MKO mice) displayed several physiological hallmarks for increase capacity. This included increased expenditure...
Trimethylsilylation of L-Fucose, followed by reaction with TMS-I, yields in situ the per-O-trimethylsilyl-α-L-fucopyranosyl iodide (2) without chromatography. Compound 2, absence a promoter, reacts alcohols to give α-L-fucopyranosides good (45-90%). The net result is that hydrogenation not an essential final step synthesis fucosides and benzyl groups may be used as temporary protecting oligosaccharide involving terminal fucosylation.
A series of deoxygenated uridine 5'-diphosphogalactose (UDP-Gal) derivatives are evaluated as donors for three different retaining galactosyltransferases using capillary electrophoresis with laser-induced fluorescence detection. The enzymes investigated were calf thymus α(1→3) galactosyltransferase (E.C. 2.4.1.151), blood group B 2.4.1.37) and Neisseria meningitidis α(1→4) galactosyltransferase. UDP-2-deoxy-Gal UDP-6-deoxy-Gal found to be active all enzymes. Preparative syntheses utilizing...
Cinchona alkaloids are effective additives for enantioselective O-H insertion of alpha-phenyldiazoacetate and water by rhodium(II) complexes. Addition silica gel promotes in the reaction rate proceeds smoothly at less than freezing point water, e.g., -10 degrees C, provided mandelate up to 50% ee. The results reported here highest asymmetric inductions obtained date insertions via a Rh-carbenoid.