A5081726824- Statistical Methods and Inference
- Financial Risk and Volatility Modeling
- Probability and Risk Models
- Monetary Policy and Economic Impact
- Spatial and Panel Data Analysis
- Insurance, Mortality, Demography, Risk Management
- Statistical Distribution Estimation and Applications
- Stochastic processes and financial applications
- Insurance and Financial Risk Management
- Statistical and numerical algorithms
- Advanced Statistical Methods and Models
- Control Systems and Identification
- Spectroscopy and Chemometric Analyses
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Fault Detection and Control Systems
- Cancer Cells and Metastasis
- Acute Myeloid Leukemia Research
- Market Dynamics and Volatility
- Complex Systems and Time Series Analysis
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Statistical Methods in Clinical Trials
- Animal Behavior and Reproduction
Charles University
2016-2025
Institute of Mathematical Statistics
2025
Prague University of Economics and Business
2017
T. G. Masaryk Water Research Institute
2011
MicroRNAs (miRs) represent a distinct class of posttranscriptional modulators gene expression with remarkable stability in sera. Several miRs are oncogenic (oncomiRs) and deregulated the pathogenesis breast cancer function to inhibit tumor suppressors. Routine blood monitoring these circulating tumor-derived products could be significant benefit diagnosis relapse detection early-stage (EBC) patients.Aim this project was determine miR-155, miR-19a, miR-181b, miR-24, relative let-7a sera 63...
Primary cutaneous T-cell lymphomas (CTCL) affect the skin and tend to transform spread. CTCL involves primarily Mycosis fungoides (MF) more aggressive Sezary syndrome (SS). Oncogenic microRNAs (miRs) are stable epigenetic inhibitors often deregulated in tumour detectable as biomarkers non-cellular fractions of peripheral blood. The tumour-specific expression miR-155, miR-203, miR-205 was shown correctly diagnose CTCL. We herein asked whether these can be used plasma for clinical monitoring....
Oncogenic microRNAs (oncomiRs) accumulate in serum due to their increased stability and thus serve as biomarkers breast cancer (BC) pathogenesis. Four oncogenic (miR-155, miR-19a, miR-181b, miR-24) one tumor suppressor microRNA (let-7a) were shown differentiate between high- low-risk early (EBC) reflect the surgical removal adjuvant therapy. Here we applied longitudinal multivariate data analyses stochastically model levels of each oncomiRs using RT-PCR measurements EBC patients (N = 133)...
Time series containing non‐negligible portion of possibly dependent zeros, whereas the remaining observations are positive, considered. They regarded as GARCH processes consisting non‐negative values. Our first aim lies in estimation omnibus model parameters taking into account semi‐continuous distribution. The hurdle distribution together with zeros cause that classical techniques fail. Two different quasi‐likelihood approaches employed. Both estimators proved to be strongly consistent and...
ABSTRACT Objectives To assess the ability, as well factors affecting of ultrasound examiners with different levels experience to detect correctly infiltration ovarian cancer in predefined anatomical locations, and evaluate inter‐rater agreement regarding presence or absence infiltration, using preacquired videoclips obtained a selected patient sample high prevalence spread. Methods This study forms part Imaging Study Advanced ovArian Cancer multicenter observational (NCT03808792). Ultrasound...
The solution to the errors-in-variables problem computed through total least squares is highly nonlinear. Because of this, many statistical procedures for constructing confidence intervals and testing hypotheses cannot be applied. One possible this dilemma bootstrapping. A nonparametric bootstrap technique could fail. Here, proper procedure provided its correctness proved. On other hand, a residual not valid suitable in case. results are illustrated simulation study. An application approach...
The studied semi‐continuous time series contains a nonnegligible portion of observations equal to single value (typically zero), whereas the remaining outcomes are strictly positive. A novel class hurdle GARCH models having dependent zero occurrences is considered and classical maximum likelihood estimation employed. However, distribution underlying innovations does not belong into exponential family, which together with dependence makes whole inference nonstandard. Consistency asymptotic...
Panel data of our interest consist a moderate number panels, while the panels contain small observations. An estimator common breaks in panel means without boundary issue for this kind scenario is proposed. In particular, novel able to detect break point even when change happens immediately after first time or just before last observation period. Another advantage elaborated that it results situations with no structural breaks. The consistency established. are illustrated through simulation...
Diabetes mellitus is unfavorably associated with cancer risk. The purpose of this multidisciplinary project was to evaluate a possible association diabetes and other comorbidities their treatment progression colorectal cancer.We investigated the correlation between pathological characteristics clinical course, including in 1004 Czech patients diagnosed surgically treated for adenocarcinoma (CRC) 1999 2016.In our data set, CRC metformin due coexisting type 2 (T2DM) developed fewer distant...