A5103540099- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Circular RNAs in diseases
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- RNA and protein synthesis mechanisms
- Ubiquitin and proteasome pathways
- Ovarian cancer diagnosis and treatment
- Genomic variations and chromosomal abnormalities
- Proteoglycans and glycosaminoglycans research
- Skin and Cellular Biology Research
- Colorectal Cancer Treatments and Studies
- Enzyme Structure and Function
- Peptidase Inhibition and Analysis
- PARP inhibition in cancer therapy
- Genetic Associations and Epidemiology
Aarhus University Hospital
2007-2025
National Cancer Centre Singapore
2021
Danish Cancer Society
1999
Abstract We currently have limited knowledge of the involvement long non-coding RNAs (lncRNAs) in normal cellular processes and pathologies. Here, we identify characterize SNHG5 as a stable cytoplasmic lncRNA with up-regulated expression colorectal cancer. Depletion induces cell cycle arrest apoptosis vitro limits tumour outgrowth vivo , whereas overexpression counteracts oxaliplatin-induced apoptosis. Using an unbiased approach, 121 transcript sites interacting cytoplasm. Importantly,...
Aberrant expression of long non-coding RNAs (lncRNAs) has been regarded as a critical component in bladder cancer (BC) and lncRNAs have associated with BC development progression although their overall functional significance is still unclear. The aim our study was to identify novel role carcinogenesis. RNA-sequencing used aberrantly expressed 8 normal 72 samples. We identified 89 that were significantly dys-regulated BC. Five lncRNAs; LINC00958, LINC01296, LINC00355, LNC-CMC1-1 LNC-ALX1-2...
We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with risks BRCA1 and BRCA2 pathogenic variant carriers. Retrospective cohort data on 18,935 12,339 female carriers of European ancestry were available. Three versions a 313 single-nucleotide polymorphism (SNP) BC PRS evaluated based whether they predict overall, estrogen receptor (ER)-negative, ER-positive BC, two overall high-grade serous EOC. Associations...
Colorectal cancer (CRC) is one of the leading causes deaths in Western countries. A significant number CRC patients undergoing curatively intended surgery subsequently develop recurrence and die from disease. MicroRNAs (miRNAs) are aberrantly expressed cancers appear to have both diagnostic prognostic significance. In this study, we identified novel miRNAs associated with CRC, their possible mechanism action. TaqMan ® Human MicroRNA Array Set v2.0 was used profile expression 667 14 normal...
Gene silencing by DNA hypermethylation of CpG islands is a well-characterized phenomenon in cancer. The effect hypomethylation particular non-CpG island genes much less well described. By genome-wide screening, we identified 105 microsatellite stable (MSS) colorectal adenocarcinomas with an inverse correlation (Spearman's ρ ≤ -0.40) between methylation and expression. Of these, 35 (33%) were hypomethylated two them, APOLD1 = -0.82) SRPX2 -0.80) selected for further analyses. Hypomethylation...
MicroRNAs (miRNAs) play a critical role in many biological processes and are aberrantly expressed human cancers. Particular miRNAs function either as tumor suppressors or oncogenes appear to have diagnostic prognostic significance. Although numerous dys-regulated colorectal cancer (CRC) only small fraction has been characterized functionally. Using high-throughput functional screening miRNA profiling of clinical samples the present study aims at identifying important for control cellular...
Recent population-based female breast cancer and prostate polygenic risk scores (PRS) have been developed. We assessed the associations of these PRS with risks for male BRCA1 BRCA2 pathogenic variant carriers.
Background and purpose: Despite advancements in genetic testing expanded eligibility criteria, underutilisation of germline for pathogenic variants BRCA1 BRCA2 (BRCA) remains evident among breast cancer (BC) patients. This observational cohort study presents real-world data on BRCA within the context clinical practice challenges, including incomplete family history under-referral. Material methods: From Danish Breast Cancer Group (DBCG) database, we included 65,117 females with unilateral...
We initiated the present study to identify new genes associated with colorectal cancer. In a previously published microarray an EST (W80763), later identified as gene hFKBP10 (NM_021939), was found be strongly expressed in tumors while absent normal mucosa. Here we describe this together its encoded protein hFKBP65 novel marker Analysis of 31 adenocarcinomas and 14 mucosa by RealTime PCR for showed significant up-regulation tumors, when compared Immunohistochemical analysis 26 matching...
No AccessJournal of UrologyInvestigative Urology1 Apr 1999LEWIS ANTIGEN MEDIATED ADHESION OF FRESHLY REMOVED HUMAN BLADDER TUMORS TO E-SELECTIN KARNA SKORSTENGAARD, ELSE MARIE VESTERGAARD, NIELS C. LANGKILDE, LISE LOTTE CHRISTENSEN, HANS WOLF, and TORBEN F. ORNTOFT SKORSTENGAARDKARNA SKORSTENGAARD More articles by this author , VESTERGAARDELSE VESTERGAARD LANGKILDENIELS LANGKILDE CHRISTENSENLISE CHRISTENSEN WOLFHANS WOLF ORNTOFTTORBEN View All Author...
Abstract Aberrant activation of the Wnt signaling pathway is causally involved in formation most colorectal cancers (CRCs). Whereas detailed knowledge exists regarding regulated protein coding genes, much less known about possible involvement non-coding RNAs. Here we used TaqMan Array MicroRNA Cards, capable detecting 664 unique human microRNAs (miRNAs), to describe changes miRNA transcriptome following disruption beta-catenin/TCF4 activity DLD1 CRC cells. Most miRNAs appeared respond...
Abstract Colorectal cancer (CRC) is one of the leading causes death in Western countries. A significant number CRC patients undergoing curative-intented surgery subsequently develop recurrence and die from disease. MicroRNAs (miRNAs) are aberrantly expressed cancers appear to have both diagnostic prognostic significance. In this study we identified novel miRNAs associated with CRC. TaqMan® Human MicroRNA Array Set v2.0 was used profile expression 667 14 normal colon mucosas 46 microsatellite...