A5044161873- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Parathyroid Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Renal and related cancers
- Cancer Research and Treatments
- Platelet Disorders and Treatments
- Protease and Inhibitor Mechanisms
- TGF-β signaling in diseases
- Food Allergy and Anaphylaxis Research
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Protein Tyrosine Phosphatases
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Genetic Syndromes and Imprinting
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Cell Adhesion Molecules Research
- Allergic Rhinitis and Sensitization
Aarhus University
2012-2022
University of Oslo
2017-2020
Colorectal cancer (CRC) is one of the leading causes deaths in Western countries. A significant number CRC patients undergoing curatively intended surgery subsequently develop recurrence and die from disease. MicroRNAs (miRNAs) are aberrantly expressed cancers appear to have both diagnostic prognostic significance. In this study, we identified novel miRNAs associated with CRC, their possible mechanism action. TaqMan ® Human MicroRNA Array Set v2.0 was used profile expression 667 14 normal...
Abstact Background The inorganic phosphate (P i ) transporter, PiT1 (SLC20A1), is ubiquitously expressed in mammalian cells. It has previously been shown that down-regulation of severely impaired the proliferation two transformed human cells lines, HepG2 and HeLa, tumorigenicity HeLa nude mice. Moreover, knock-out mice do not survive past E12.5 from E10.5, embryos were found to be growth-retarded showed reduced liver Isolated mouse embryonic fibroblasts with knocked out as well expression...
The inorganic phosphate transporter PiT1 (SLC20A1) is ubiquitously expressed in mammalian cells. We recently showed that overexpression of human was sufficient to increase proliferation two strict density-inhibited cell lines, murine fibroblastic NIH3T3 and pre-osteoblastic MC3T3-E1 cells, allowed the cultures grow higher densities. In addition, upon transformation cells increased ability form colonies soft agar. cellular regulation expression supports utilize levels control proliferation,...
Factor VII activating protease (FSAP) is a circulating serine implicated in thrombosis, atherosclerosis, stroke, and cancer. Using an overexpression strategy, we have systematically investigated the role of activated receptors (PAR)-1, -2, -3, -4 on FSAP-mediated signaling HEK293T A549 cells. Cleavage PAR-reporter constructs MAPK phosphorylation was used to monitor receptor activation. FSAP cleaved PAR-2 lesser degree PAR-1, but not PAR-3 or PAR-4 both cell types. Robust activation response...
Abstract Pharmacological activation of the STING pathway is being assessed as a strategy to stimulate both innate and adaptive arms immune system trigger an anti-tumor response in so-called "cold" tumors. Although first generation agonists dosed intratumorally showed strong preclinical models, positive clinical data has so far been limited, potentially due reduced efficacy non-injected Newer classes that are delivered systemically expected deliver more consistent predictable levels...
<h3>Background:</h3> Type I interferonopathies are a group of rare monogenic diseases causing over-activation signaling pathways ultimately leading to increased type Interferon (IFN) in the plasma and immune system. AGS is inflammatory disease with onset at birth or early infancy that principally caused by mutations genes encoding proteins cytosolic nuclease activity e.g., RNAseH2A, -B -C Trex1. Mutations Trex1 lead accumulation DNA cytosol which activates canonical DNA-sensing cGAS-STING...
Abstract Colorectal cancer (CRC) is one of the leading causes death in Western countries. A significant number CRC patients undergoing curative-intented surgery subsequently develop recurrence and die from disease. MicroRNAs (miRNAs) are aberrantly expressed cancers appear to have both diagnostic prognostic significance. In this study we identified novel miRNAs associated with CRC. TaqMan® Human MicroRNA Array Set v2.0 was used profile expression 667 14 normal colon mucosas 46 microsatellite...