A5023765050- Dementia and Cognitive Impairment Research
- Cognitive Functions and Memory
- Patient-Provider Communication in Healthcare
- Ethics in Clinical Research
- Alzheimer's disease research and treatments
- Technology Use by Older Adults
- Cancer-related cognitive impairment studies
- Neurobiology of Language and Bilingualism
- Memory Processes and Influences
- Head and Neck Cancer Studies
- Identity, Memory, and Therapy
- Functional Brain Connectivity Studies
- Palliative Care and End-of-Life Issues
- Biomedical Text Mining and Ontologies
- Topic Modeling
- Interpreting and Communication in Healthcare
- Autism Spectrum Disorder Research
- Hearing Loss and Rehabilitation
- Family Support in Illness
- Memory and Neural Mechanisms
- Digital Storytelling and Education
- Medical Imaging and Analysis
- Aging and Gerontology Research
- Telemedicine and Telehealth Implementation
- Bayesian Modeling and Causal Inference
University of Wisconsin–Madison
2021-2025
National Center for Geriatrics and Gerontology
2023
Abstract Remote monitoring of cognition holds the promise to facilitate case-finding in clinical care and individual detection cognitive impairment research settings. In context Alzheimer’s disease, this is particularly relevant for patients who seek medical advice due memory problems. Here, we develop a remote digital composite (RDMC) score from an unsupervised assessment battery focused on episodic long-term recall assess its construct validity, retest reliability, diagnostic accuracy when...
Stage II pre-clinical Alzheimer's disease is defined by the presence of increased amyloid-beta evidenced fluid and/or imaging biomarkers, in absence clinical signs and symptoms. Previous research suggests that sex differences exist on measures story recall, such as Wechsler memory scale-revised logical test total score. However, a composite metric proper names from have not been investigated, relationships between amyloid positivity longitudinal are unclear. We examined trajectories score...
Background: Early detection of Alzheimer's disease (AD) is crucial; however, standard neuropsychological tests often lack sensitivity. Process scores, such as proper name (PN) recall from Logical Memory (LM), may improve the AD-related biomarker positivity. We examined whether baseline PN predicted future cerebrospinal fluid (CSF) amyloid (Aβ42/Aβ40) and tau (pTau181) status, status trajectories. Methods: analyzed 271 cognitively unimpaired BIOCARD participants (mean age = 57.3, 60.3%...
Abstract INTRODUCTION Information on the psychosocial impact of Alzheimer's disease (AD) biomarker testing in adults at risk AD is needed to inform best practices for communicating results. METHODS Ninety‐nine cognitively unimpaired older learned amyloid positron emission tomography (PET) results (mean age = 72.0 ± 4.8, 95% White, 28% elevated amyloid). Linear mixed‐effects regression models were used test main effects and interaction PET result × time outcomes up 6 months after learning...
In the asymptomatic "preclinical" phase of Alzheimer's disease (AD), abnormal biomarkers indicate risk for developing cognitive impairment. Biomarker information is increasingly being disclosed to participants in research settings, and biomarker testing results disclosure will be implemented clinical settings future. has potential psychosocial benefits harms, impacting affected individuals their support person(s). Limited data are available about with whom share results, that necessary...
Abstract Introduction We developed the Alzheimer’s Biomarker Survey to assess willingness enroll in biomarker studies that disclose results and anticipated reactions an elevated result. Methods Participants included cognitively unimpaired adults enrolled longitudinal AD ( n = 334, mean age 64.8 ± 7.7, 44% non-Hispanic Black or African American). Exploratory confirmatory factor analyses determined latent structure comprising learning results. Measurement invariance was tested across racial...
Abstract Mobile app-based unsupervised monitoring of cognition holds the promise to facilitate case-finding in clinical care and individual detection cognitive impairment research settings. In context Alzheimer’s disease, this is particularly relevant for patients who seek medical advice due memory complaints. Here we developed a Remote Digital Memory Composite (RDMC) score from an remote mobile assessment battery focused on episodic long-term recall assessed its construct validity, retest...
Abstract Introduction Recruitment and retention pose a significant challenge to Alzheimer's disease (AD) research. Returning AD biomarker results participants has been proposed as means improve recruitment retention. We present findings related participant satisfaction, utility, impact on research attitudes from the amyloid positron emission tomography (PET) disclosure sub‐study within Wisconsin Registry for Prevention (WRAP). Methods Ninety‐nine cognitively unimpaired WRAP learned their PET...
Abstract Background Previous studies have found connections between recall of proper names (PN) and amyloid positivity in cognitively unimpaired (CU) adults at risk for Alzheimer’s Disease (AD; Mueller et al., 2020). Given the promising prospect employing plasma‐based biomarkers to determine burden, we looked associations longitudinal change PN total score from Logical Memory (LM) story test plasma pTau217. Method Participants Wisconsin Registry Prevention (WRAP) study, who were CU baseline...
Clinical assessments often use complex picture description tasks to elicit natural speech patterns and magnify changes occurring in brain regions implicated Alzheimer's disease dementia. As The Cookie Theft task is used the largest dementia cohort studies available, we aimed create algorithms that could characterize visual narrative path a participant takes describing what happening this image. We proposed spatio-semantic graphs, models based on graph theory transform participants'...
Background: As Alzheimer disease (AD) biomarker testing becomes more widely available, adults may opt to learn results. Considering potential reactions learning results can guide prebiomarker and postbiomarker education counseling programs. Methods: Cognitively healthy enrolled in observational research responded a telephone survey about AD risk information (n=334; 44% Black or African American; mean age=64.9±7.0). Multiple linear regression models tested if contextual factors predicted...
Objective: Frequent and remote cognitive assessment may improve sensitivity to subtle decline associated with preclinical Alzheimer’s disease (AD). The objective of this study was evaluate the feasibility acceptability repeated memory in late middle-aged older adults. Participants Methods: We recruited participants from a longitudinal aging cohort complete three medial temporal lobe-based paradigms (Object-In-Room Recall [ORR], Mnemonic Discrimination for Objects Scenes [MDT-OS], Complex...
Abstract Background Quantifying the temporal progression of key pathophysiological events in Alzheimer’s disease is crucial for staging disease, dementia risk assessment, and informing clinical trials. This work extends a novel algorithm (sampled iterative local linear approximation; SILLA) developed modeling PET trajectories to: 1) generate unified CSF amyloid accumulation timeline, 2) characterize biomarker cognitive changes AD. Method 941 participants from Wisconsin Registry Prevention,...
Abstract Background Frequent and remote cognitive assessment may improve sensitivity to subtle decline associated with preclinical Alzheimer’s disease (AD). However, repeated testing can result in unintended inflation of scores, due practice effects. The objective this study is evaluate the extent sessions non‐identical stimuli on performance determine if design or amyloid PET status moderates impact practice. Method Participants were recruited from longitudinal aging cohorts complete medial...
Abstract Background Frequent and remote cognitive assessment may improve sensitivity to subtle decline associated with preclinical Alzheimer’s disease (AD). Our objective was evaluate the feasibility, reliability, construct validity of repeated memory in late middle‐aged older adults. Method Participants were recruited from longitudinal aging cohorts complete medial temporal lobe‐based paradigms (Object‐In‐Room Recall [ORR], Mnemonic Discrimination for Objects Scenes [MDT‐OS], Complex Scene...
Abstract Background Sensitive screening for early Alzheimer’s disease (AD)‐related cognitive decline are needed. Prior research links high beta‐amyloid (Aβ) levels to reduced proper name (PN) retrieval in individuals without impairment. We examined whether language‐related regional tau from PET associated with Logical Memory (LM) recall, accounting LM covariates. Method Participants included n = 396 the Wisconsin Registry Prevention (WRAP) story amyloid ([11C]Pittsburgh Compound‐B, PiB), and...
Abstract Background Sensitive screening for early Alzheimer’s disease (AD)‐related cognitive decline are needed. Prior research links high beta‐amyloid (Aß) levels to reduced proper name (PN) retrieval in individuals without impairment. We examined whether language‐related regional tau from PET associated with Logical Memory (LM) recall, accounting LM covariates. Method Participants included n=396 the Wisconsin Registry Prevention (WRAP) story amyloid ([11C]Pittsburgh Compound‐B, PiB), and...
Abstract Background Difficulty recalling proper names (PNs; e.g., of people/places) is a common complaint individuals at risk for Alzheimer’s disease (AD). We recently reported that cognitively unimpaired (CU), positron emission tomography amyloid‐beta (Aβ) positive (A+) recalled fewer PNs than Aβ negative on the Logical Memory (LM) delayed story recall test. Declines in LM total scores (LMtot) have been associated with cerebrospinal fluid (CSF) A+ and tau (T); relationship between AD‐CSF...
Abstract Background Use of telephone‐based cognitive assessments became more widespread during the COVID‐19 pandemic. The National Alzheimer’s Coordinating Center (NACC) developed battery (T‐Cog) to ensure continued data collection and participant retention. objective this study was (1) assess feasibility reliability T‐Cog collected pandemic, (2) evaluate these in context prior in‐person (3) inform future use remote collection. Method Wisconsin ADRC Clinical Core staff administered batteries...
Neuropsychological measures sensitive to decline in the preclinical phase of Alzheimer’s disease (AD) are needed. We previously demonstrated that higher amyloid-beta (Aβ) assessed by positron emission tomography cognitively unimpaired (CU) participants was associated with recall fewer proper names (PNs) Logical Memory (LM) story recall. The current study investigated association between PNs and cerebrospinal fluid (CSF) biomarkers (Aβ42/40, phosphorylated tau181, (pTau181), neurofilament...
Abstract Background Errors and repetitions on verbal fluency list learning tasks have been found to predict progression MCI differentiate between healthy aging, MCI, dementia. This study examined whether errors and/or measures were cross‐sectionally associated with amyloid pathology in baseline cognitively unimpaired (CU) adults, provided additional information beyond traditional total score measures. Method We included 437 participants from the Wisconsin Registry for Alzheimer’s Prevention...