A5066440154- Dementia and Cognitive Impairment Research
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Memory Processes and Influences
- Functional Brain Connectivity Studies
- Cognitive Functions and Memory
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Deception detection and forensic psychology
- Health, Environment, Cognitive Aging
- Neuroscience and Neuropharmacology Research
- Identity, Memory, and Therapy
- Neural and Behavioral Psychology Studies
- Neurobiology of Language and Bilingualism
- Traumatic Brain Injury Research
- Maternal Mental Health During Pregnancy and Postpartum
- Machine Learning in Healthcare
- Inflammation biomarkers and pathways
- Neurological Disease Mechanisms and Treatments
- Evolutionary Psychology and Human Behavior
- Cognitive Abilities and Testing
- Autopsy Techniques and Outcomes
- Health and Well-being Studies
- Menopause: Health Impacts and Treatments
Liverpool John Moores University
2016-2025
South African Medical Research Council
2024
Liverpool Hope University
2013-2018
Nathan Kline Institute for Psychiatric Research
2011-2017
City University of New York
2016
The Graduate Center, CUNY
2016
University College London
2016
Alzheimer's Association
2016
NYU Langone Health
2016
Leeds Beckett University
2016
Objective: Major depressive disorder is common in the elderly, and symptoms are often not responsive to conventional antidepressant treatment, especially long term. Soluble oligomeric aggregated forms of amyloid beta peptides, 42, impair neuronal synaptic function. Amyloid 42 main component plaques implicated Alzheimer's disease. peptides also induce a state rodents disrupt major neurotransmitter systems linked depression. The authors assessed whether depression was associated with CSF...
Abstract INTRODUCTION Menopausal hormone therapy (MHT), along with the apolipoprotein E ( APOE ) ε4 allele, has been suggested as a possible risk factor for Alzheimer's disease (AD). However, relationship between MHT and cerebrospinal fluid (CSF) biomarkers is unknown: we investigated this association, whether carrier status moderates it. METHODS In an observational study of 136 cognitively unimpaired female participants M age = 66.0; standard deviation 6.3), examined use alone or in...
Abstract Major depressive disorder (MDD), common in the elderly, is a risk factor for dementia. Abnormalities glutamatergic neurotransmission via N -methyl- d -aspartate receptor (NMDA-R) have key role pathophysiology of depression. This study examined whether depression was associated with cerebrospinal fluid (CSF) levels NMDA-R neurotransmission-associated amino acids cognitively intact elderly individuals MDD and age- gender-matched healthy controls. CSF obtained from 47 volunteers (MDD...
Brain derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of depression as well neuropsychiatric and neurodegenerative disorders. Recent studies show a role BDNF energy metabolism body weight regulation. We examined levels plasma cerebrospinal fluid (CSF) samples from age matched elderly depressed control subjects. Also, association with age, gender, weight, mass index (BMI), cognitive performance was evaluated. did not find any significant differences CSF between...
Alzheimer's disease (AD) can be diagnosed by in vivo abnormalities of amyloid-β plaques (A) and tau accumulation (T) biomarkers. Previous studies have shown that analyses serial position performance episodic memory tests, especially, delayed primacy, are associated with AD pathology even individuals who cognitively unimpaired. The earliest signs cortical observed medial temporal lobe (MTL) regions, yet it is unknown if markers also early load these regions. This study unimpaired older...
Criterion- versus distribution-shift accounts of frequency and strength effects in recognition memory were investigated with Type-2 signal detection receiver operating characteristic (ROC) analysis, which provides a measure metacognitive monitoring. Experiment 1 demonstrated frequency-based mirror effect, higher hit rate lower false alarm rate, for low words compared high words. In 2, the authors manipulated item repetition, showed an increased but no effect on rate. Whereas Type-1 indices...
Abstract Depressed individuals are twice as likely to develop Alzheimer’s disease (AD) compared controls. Brain amyloid-β (Aβ) deposition is believed have a major role in AD pathogenesis but studies also suggest associations of Aβ dynamics and depression. The aim this study was test if plasma levels longitudinally associated late-life We measured 1-40 (Aβ40) 1-42 (Aβ42) peptides for three consecutive years 48 cognitively intact elderly subjects with depressive disorder (LLMD) 45 age-matched...
One of the cognitive changes associated with Alzheimer's disease is a diminution primacy effect, i.e., tendency toward better recall items studied early on list compared rest. We examined whether learning and words predicted subsequent decline in 204 elderly subjects who were non-demented cognitively intact when first examined. Our results show that poorer performance Rey Auditory Verbal Learning Test delayed trials, but not immediate an effective predictor general function. This pattern can...
AbstractRecognition memory studies often find that emotional items are more likely than neutral to be labelled as studied. Previous work suggests this bias is driven by increased strength/familiarity for items. We explored strength and interpretations of effect with the conjecture stimuli might seem familiar because they share features studied from same category. Categorical effects were manipulated in a recognition task presenting lists small, medium or large proportion words. The liberal...
Abstract INTRODUCTION We investigated the association of inflammatory mechanisms with markers Alzheimer's disease (AD) pathology and rates cognitive decline in AD spectrum. METHODS studied 296 cases from Deutsches Zentrum für Neurodegenerative Erkrankungen Longitudinal Cognitive Impairment Dementia Study (DELCODE) cohort, an extension cohort 276 Disease Neuroimaging Initiative study. Using Bayesian confirmatory factor analysis, we constructed latent factors for synaptic integrity, microglia,...
The World Health Organisation's (WHO) key population-based strategy for ending the human immunodeficiency virus (HIV) epidemic is universal HIV test and treat (UTT) along with pre-exposure prophylaxis (PrEP), post-exposure (PEP). Despite successful scale-up of UTT in sub-Saharan Africa (SSA), quality life (QoL) people living (PLHIV) remains sub-optimal. Poor QoL PLHIV may threaten UNAIDS 95-95-95 programme targets. Monitoring has become a focus research among other outcomes so as to...
Abstract Objectives Serial position effects have been found to discriminate between normal and pathological aging, predict conversion from Mild Cognitive Impairment (MCI) Alzheimer’s disease (AD). Different scoring methods used estimate the accuracy of these predictions. In current study, we investigated delayed primacy as predictor progression early MCI over established diagnostic memory methods. We also compared three serial (regional, standard scores) determine which measure is most...
ABSTRACT Objectives: Individuals with Alzheimer's disease (AD) present poor immediate primacy recall accompanied by intact or exaggerated recency, which then tends to decline after a delay. Bruno et al. ( Journal of Clinical and Experimental Neuropsychology , Vol. 38, 2016, pp. 967–973) have shown that higher ratio scores between delayed recency (i.e. the ratio; Rr) are associated cognitive in high-functioning older individuals. We tested whether Rr predicted conversion early mild impairment...
Due to advances in the early detection of Alzheimer's disease (AD) biomarkers including beta-amyloid (Aβ), neuropsychological measures that are sensitive concurrent, subtle changes cognition critically needed. Story recall tasks have shown sensitivity memory declines persons with mild cognitive impairment (MCI) and stage dementia, as well autosomal dominantly inherited AD up 10 years prior a dementia diagnosis. However, evidence is inconclusive regarding relationships between Aβ story...
Objective: Blood-based biomarkers are valued for their lower cost and less invasive nature, though issues with widespread implementation accessibility remain. Process-based scores from story recall have been shown to detect neuronal network disturbances typical of Alzheimer's disease (AD) pathology more effectively than traditional metrics. This study examined the associations between process-based concurrent plasma AD in older adults without dementia, while also comparing them Additionally,...
Abstract We introduce a special issue of the Journal Neuropsychology dedicated to recent paradigm shift in Alzheimer's disease diagnosis. Joint workgroups from (US) National Institute on Aging and Association (NIA‐AA) recently issued policy guidelines reclassifying as biological entity. These onus diagnosis favour protein biomarkers, relegating cognitive symptoms (e.g. subjective memory language disorders) supportive rather than core features. invited experts study Related Disorders (ADRDs)...
Stage II pre-clinical Alzheimer's disease is defined by the presence of increased amyloid-beta evidenced fluid and/or imaging biomarkers, in absence clinical signs and symptoms. Previous research suggests that sex differences exist on measures story recall, such as Wechsler memory scale-revised logical test total score. However, a composite metric proper names from have not been investigated, relationships between amyloid positivity longitudinal are unclear. We examined trajectories score...
Background: Early detection of Alzheimer's disease (AD) is crucial; however, standard neuropsychological tests often lack sensitivity. Process scores, such as proper name (PN) recall from Logical Memory (LM), may improve the AD-related biomarker positivity. We examined whether baseline PN predicted future cerebrospinal fluid (CSF) amyloid (Aβ42/Aβ40) and tau (pTau181) status, status trajectories. Methods: analyzed 271 cognitively unimpaired BIOCARD participants (mean age = 57.3, 60.3%...