A5067276800- Dementia and Cognitive Impairment Research
- Maternal Mental Health During Pregnancy and Postpartum
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Machine Learning in Healthcare
- Menopause: Health Impacts and Treatments
- Attention Deficit Hyperactivity Disorder
- Memory Processes and Influences
- Memory and Neural Mechanisms
- Mental Health Research Topics
- Autopsy Techniques and Outcomes
- Cognitive Functions and Memory
- Topic Modeling
- Mental Health and Psychiatry
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Health, Environment, Cognitive Aging
- Identity, Memory, and Therapy
- Frailty in Older Adults
- Estrogen and related hormone effects
- Obsessive-Compulsive Spectrum Disorders
- Artificial Intelligence in Healthcare and Education
- EEG and Brain-Computer Interfaces
- Decision-Making and Behavioral Economics
- Health disparities and outcomes
Liverpool John Moores University
2022-2025
Aston University
2018-2023
Abstract INTRODUCTION Menopausal hormone therapy (MHT), along with the apolipoprotein E ( APOE ) ε4 allele, has been suggested as a possible risk factor for Alzheimer's disease (AD). However, relationship between MHT and cerebrospinal fluid (CSF) biomarkers is unknown: we investigated this association, whether carrier status moderates it. METHODS In an observational study of 136 cognitively unimpaired female participants M age = 66.0; standard deviation 6.3), examined use alone or in...
Alzheimer's disease (AD) can be diagnosed by in vivo abnormalities of amyloid-β plaques (A) and tau accumulation (T) biomarkers. Previous studies have shown that analyses serial position performance episodic memory tests, especially, delayed primacy, are associated with AD pathology even individuals who cognitively unimpaired. The earliest signs cortical observed medial temporal lobe (MTL) regions, yet it is unknown if markers also early load these regions. This study unimpaired older...
Impulsivity is regarded as a multifaceted construct that comprises two dimensions: rapid-response impulsivity and reward-delay impulsivity. It unclear, however, which aspects of trait impulsivity, assessed by self-report measures are related to and/or different results have been reported in studies using both cognitive measures. This study aimed directly relate individuals at low- or high-levels on dimensions, specifically Participants were classified into high- low-impulsivity groups based...
Objective: Blood-based biomarkers are valued for their lower cost and less invasive nature, though issues with widespread implementation accessibility remain. Process-based scores from story recall have been shown to detect neuronal network disturbances typical of Alzheimer's disease (AD) pathology more effectively than traditional metrics. This study examined the associations between process-based concurrent plasma AD in older adults without dementia, while also comparing them Additionally,...
Background: Early detection of Alzheimer's disease (AD) is crucial; however, standard neuropsychological tests often lack sensitivity. Process scores, such as proper name (PN) recall from Logical Memory (LM), may improve the AD-related biomarker positivity. We examined whether baseline PN predicted future cerebrospinal fluid (CSF) amyloid (Aβ42/Aβ40) and tau (pTau181) status, status trajectories. Methods: analyzed 271 cognitively unimpaired BIOCARD participants (mean age = 57.3, 60.3%...
Background Wordlist and story recall tests are routinely employed in clinical practice for dementia diagnosis. In this study, our aim was to establish how well-standard metrics compared process scores derived from wordlist predicting biomarker determined Alzheimer's disease, as defined by CSF ptau/Aβ42 ratio.Methods Data 295 participants (mean age = 65 ± 9.) were drawn the University of Wisconsin – Madison Disease Research Center (ADRC) Registry Prevention (WRAP). Rey's Auditory Verbal...
Abstract We propose a novel method to assess delayed primacy in the Consortium Establish Registry for Alzheimer's Disease (CERAD) memory test. then examine whether this measure predicts post mortem disease (AD) neuropathology individuals who were clinically unimpaired at baseline. A total of 1096 selected from Rush Center database registry. All participants baseline, and had subsequently undergone brain autopsy. Average age baseline was 78.8 (6.92). Bayesian regression analysis carried out...
The preeminent in vivo cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are amyloid β 1-42 (Aβ42), phosphorylated Tau (p-tau), and total (t-tau). goal this study was to examine how well traditional (total delayed recall) process-based (recency ratio [Rr]) measures derived from Rey's Auditory Verbal Learning test (AVLT) were associated with these biomarkers.Data 235 participants (Mage = 65.5, SD 6.9), who ranged cognitively unimpaired mild cognitive impairment, for whom CSF...
Recency refers to the information learned at end of a study list or task. forgetting, as tracked by ratio between recency recall in immediate and delayed conditions, i.e., (Rr), has been applied list-learning tasks, demonstrating its efficacy predicting cognitive decline, conversion mild impairment (MCI), cerebrospinal fluid (CSF) biomarkers neurodegeneration. However, little is known whether Rr can be effectively story tasks. To address this question, data were extracted from database...
Word-list recall tests are routinely used for cognitive assessment, and process scoring may improve their accuracy. We examined whether Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) derived, process-based digital biomarkers (DCBs) at baseline predicted Clinical Dementia Rating (CDR) longitudinally compared them to standard metrics. Analyses were performed with Neuroimaging Initiative (ADNI) data from 330 participants (mean age = 71.4 ± 7.2). conducted regression analyses...
INTRODUCTION: We propose a novel method to assess delayed primacy in the CERAD memory test. then examine whether this measure predicts post mortem Alzheimers disease (AD) neuropathology individuals who were clinically unimpaired at baseline. METHODS: A total of 1096 selected from Rush Disease Center database registry. All participants baseline, and had subsequently undergone brain autopsy. Average age baseline was 78.8 (6.92). Bayesian regression analysis carried out with global pathology as...
Objective: Process-based scores of episodic memory tests, such as the recency ratio (Rr), have been found to compare favourably to, or be better than, most conventional “traditional” employed estimate ability in older individuals (Bock et al., Citation2021; Bruno Citation2019). We explored relationship between process-based and hippocampal volume adults, while comparing traditional story recall-derived scores, examine potential differences their predictive abilities. Methods: analysed data...
The association between depressive symptomatology and cognitive decline has been examined using the Centre for Epidemiologic Studies-Depression Scale (CES-D), however, concerns have raised about this self-report measure. Here, we how CES-D total score from 14- 10-item versions compared to 20-item version in predicting progression a cognitively unimpaired baseline. Data 1,054 participants were analysed ordinal logistic regression, alongside moderator receiver-operating characteristics curve...
The association between depressive symptomatology and cognitive decline has been examined using the Centre for Epidemiologic Studies-Depression Scale (CES-D); however, concerns have raised about this self-report measure. Here, we how CES-D total score from 14- 10-item versions compared to 20-item version in predicting progression a cognitively unimpaired baseline. Data 1054 participants were analysed ordinal logistic regression, alongside moderator receiver-operating characteristics curve...
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Abstract Background Depressive symptomatology is associated with cognitive decline and greater risk for dementia. Studies have examined this association using self‐report measures such as the Centre Epidemiologic Studies‐Depression Scale (CES‐D; Radloff, 1991). Although CES‐D was originally designed a 20‐item scale, certain items been reported to misrepresent depressive symptoms due sex cultural differences, which are addressed in 14‐item version of measure (Carleton et al., 2013). The aim...
Abstract Background Word‐list recall tests are routinely employed in clinical practice for dementia screening. Process scoring and latent modeling of these tests, where underlying neurocognitive mechanisms exploited, have shown potential to enhance test accuracy without requiring redesign. We examined Embic’s digital biomarker M , a measure derived from multinomial processing trees hierarchical Bayesian computational methods, as predictor conversion mild cognitive impairment (MCI)...
Abstract Background Word‐list and story recall tests are routinely employed in clinical practice for dementia screening. Previous research has shown that both types of predictive subsequent diagnoses dementia, including when examining process scores such as forgetting rate. In this study, our aim was to establish how well standard metrics compared derived from word‐list predicting biomarker‐determined Alzheimer’s disease (bdAD), defined by CSF p‐tau/Abeta42 ratio. Method Data 381...