A5018646670- Birth, Development, and Health
- Cerebral Palsy and Movement Disorders
- Infant Development and Preterm Care
- Family and Disability Support Research
- Early Childhood Education and Development
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Poverty, Education, and Child Welfare
- Child Nutrition and Feeding Issues
- Health disparities and outcomes
- Global Health Care Issues
- Neonatal and fetal brain pathology
- Delphi Technique in Research
- Food Security and Health in Diverse Populations
- Neonatal Respiratory Health Research
- Ubiquitin and proteasome pathways
- Genomics and Rare Diseases
- Epilepsy research and treatment
- Healthcare Policy and Management
- Health Systems, Economic Evaluations, Quality of Life
- Education Systems and Policy
- Down syndrome and intellectual disability research
- Smoking Behavior and Cessation
- Health Literacy and Information Accessibility
- 14-3-3 protein interactions
University of Oxford
2021-2025
University of Tennessee Health Science Center
2018-2021
Centre for Addiction and Mental Health
2019-2021
University of Tennessee at Knoxville
2021
Baylor University
2016-2018
National Bureau of Economic Research
2018
St George’s University Hospitals NHS Foundation Trust
2017
Canadian Centre for Applied Research in Cancer Control
2012-2016
University of British Columbia
2012-2016
Simon Fraser University
2015
Targeted whole-exome sequencing (WES) is a powerful diagnostic tool for broad spectrum of heterogeneous neurological disorders. Here, we aim to examine the impact on diagnosis, treatment and cost with early use targeted WES in early-onset epilepsy. was performed 180 patients epilepsy (≤5 years) unknown cause. Patients were classified as Retrospective (epilepsy diagnosis >6 months) or Prospective <6 months). an Ion Proton™ variant reporting restricted sequences 620 known genes. Diagnostic...
It is estimated that millions of North Americans would qualify for lung cancer screening and billions dollars national health expenditures be required to support population-based computed tomography programs. The decision implement such programs should informed by data on resource utilization costs.Resource were collected prospectively from 2059 participants in the Pan-Canadian Early Detection Lung Cancer Study using low-dose (LDCT). Participants who had 2% or greater risk over 3 years a...
Abstract Family quality of life (FQoL) outcomes collected during the first year COVID‐19 has been combined with 2018 data to estimate outbreak's impact on parental a sample 230 families syndromic autistic children and those intellectual disabilities (IDs). Despite challenges imposed by outbreak, our study found that FQoL reported participating parents appears be similar ratings from prepandemic same conditions. Parents in generally displayed stable functioning trajectory as measured...
Children with autism have a significantly lower quality of life compared their neurotypical peers. While multiple studies quantified the impact on health-related (HRQoL) through standardized surveys such as PedsQL, none specifically investigated syndromic autism. Here we evaluate HRQoL in children diagnosed three genetic disorders that strongly predispose to autism: Phelan-McDermid syndrome (PMD), Rett (RTT), and SYNGAP1-related intellectual disability (SYNGAP1-ID). We find most severely...
Acute Myeloid Leukaemia (AML) is a rare but serious group of diseases that require critical decision-making for curative treatment. Over the past decade, scientific discovery has revealed dozens prognostic gene mutations AML while sequencing costs have plummeted. In this study, we compared cost-effectiveness multigene integrative analysis (genomic analysis) with standard molecular testing currently used diagnosis intermediate-risk AML. We decision analytic model data and outcomes from...
Aims Cemented hemiarthroplasty is an effective form of treatment for most patients with intracapsular fracture the hip. However, it remains unclear whether there are subgroups who may benefit from alternative operation a modern uncemented – aim this study was to investigate issue. Knowledge about heterogeneity effects important surgeons in order target operations towards specific would most. Methods We used causal forest analysis compare subgroup- and individual-level between cemented aged...
Abstract Background Knowledge brokering is a knowledge translation approach that has been gaining popularity in Canada although the effectiveness unknown. This study evaluated of generalised, exclusively email-based prompts versus personalised remote broker for delivering evidence-based mood management interventions within an existing smoking cessation programme primary care settings. Methods The design cluster randomised controlled trial 123 Ontario Family Health Teams participating Smoking...
Socioemotional development in early childhood has long-term impacts on health status and social outcomes, racial socioeconomic disparities socioemotional skills emerge life. The Special Supplemental Nutrition Program for Women, Infants, Children (WIC) is an nutrition intervention with the potential to ameliorate these disparities. Our objective was assess impact of WIC a longitudinal study. We examined association between participation scores Brief Infant Toddler Social Emotional Assessment...
Perinatal regionalization is linked to improved neonatal outcomes; however, the effects on long-term outcomes in cerebral palsy (CP) are not known. We estimate effect of highest levels care available at delivery risk developing a nonambulatory CP status.Children with born Quebec from Canadian Registry excluding postneonatal causes were included (N=360). level status among children using propensity score matching and instrumental variables methods adjust for differences case mix three groups...
Abstract Background To examine the impact on diagnosis, treatment and cost with early use of targeted whole-exome sequencing (WES) in early-onset epilepsy. Methods WES was performed 50 patients epilepsy (≤ 5 years) unknown cause. Patients were classified as retrospective (epilepsy diagnosis > 6 months) or prospective < months). an Ion ProtonTM variant reporting restricted to sequences 565 known genes. Diagnostic yield time calculated. An analysis also performed. Results A...
Between July 2020 and January 2021, 230 principal caregivers completed a questionnaire to measure proxy-assessed health-related quality of life outcomes (HRQoL), behavioral in children with syndromic autism spectrum disorders COVID-19 induced changes lifestyle environments. HRQoL reported earlier during the pandemic were generally worse compared those later. reduction caregiver's mental health appointments, hours spent watching TV associated decreases increased likelihood problematic...
ABSTRACT BACKGROUND Children with autism have a significantly lower quality of life compared their neurotypical peers. While multiple studies quantified the impact on health-related (HRQoL) through standardized surveys such as PedsQL, none specifically investigated syndromic spectrum disorder children’s HRQoL or family life. Here we evaluate in children diagnosed three Autism Spectrum Disorders (ASDs): Phelan-McDermid syndrome (PMD), Rett (RTT), and SYNGAP1 -related intellectual disability (...