A5110002904- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Photoreceptor and optogenetics research
- Adipose Tissue and Metabolism
- Wildlife Ecology and Conservation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer therapeutics and mechanisms
- COVID-19 and healthcare impacts
- Colorectal Cancer Screening and Detection
- Hepatitis C virus research
- Endoplasmic Reticulum Stress and Disease
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Plant Parasitism and Resistance
- Chronic Lymphocytic Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Receptor Mechanisms and Signaling
- Ecology and biodiversity studies
- Barrier Structure and Function Studies
- T-cell and Retrovirus Studies
- Human-Animal Interaction Studies
- Acute Lymphoblastic Leukemia research
Jikei University School of Medicine
2025
National Hospital Organization
2004-2023
Hokkaido University
1972-2008
The University of Tokyo
2005
Asahikawa Medical College Hospital
1978-1995
National Hospital
1994
The University of Texas Health Science Center at San Antonio
1978
<h3>Importance</h3> The COVID-19 pandemic has delayed medical consultations, possibly leading to the diagnosis of gastrointestinal cancer at advanced stages. <h3>Objective</h3> To evaluate stage among patients with in Japan before and during pandemic. <h3>Design, Setting, Participants</h3> This retrospective cohort study included a hospital-based registry who were diagnosed (ie, esophageal, gastric, colorectal, pancreatic, liver, biliary tract cancers) between January 2016 December 2020 2...
Large herbivores are in decline much of the world, including sub-Saharan Africa, and true apex carnivores like lion ( Panthera leo ) parallel with their prey. As a consequence, competitively subordinate African wild dog Lycaon pictus simultaneously experiencing costly reduction resources beneficial dominant competitors. The net effect is not intuitively obvious, but dogs’ density, survival, reproduction all low areas that strongly affected by prey depletion. To assess whether these...
• Nineteen samples of DNA from squamous cell carcinoma the upper aerodigestive tract were analyzed by Southern blot hybridization for presence human papillomavirus (HPV) DNA. Two contained HPV 16 or its homologous sequence. In one maxillary carcinoma, sequences to detected. tonsillar sequence was also shown be present. The patients positive female and had neither smoking nor drinking habits. These results indicate that infections may play a role in development some types carcinomas tract....
This retrospective cohort study compared the number of newly diagnosed patients, stage at diagnosis, and detection process gastrointestinal cancers based on hospital-based cancer registry data two tertiary Japanese hospitals. The pre-COVID-19 period was from January 2017 to February 2020, with phase 1 (midst COVID-19 pandemic) March December 2020 2 (the transition "new normal") 2021. Each month, patients esophageal, gastric, colorectal, pancreatic, liver, biliary tract were aggregated,...
GM1 gangliosidosis is a lysosomal storage disorder (LSD) and caused by genetic defects in the β-galactosidase (β-gal). The primary substrate of β-gal ganglioside (GM1), sialylated glycosphingolipid abundant central nervous system (CNS). deficiency causes to accumulate neural cells leading rapid decline psychomotor functions, seizures, premature death. There currently no therapy available. Although enzyme replacement (ERT) has been approved for other LSDs, its effects on CNS are limited owing...
Electron microscopic observations of mammalian pineal glands have mainly been made on rodents, especially rats. However, there is no comparative ultrastructural investigation pineals various rodent species. In the present experiments several species rodents were used, but here will be described primarily results obtained from mouse and chinchilla glands. Pineals immersed in ice-cold buffered 6% paraformaldehyde 2% OsO 4 mixture (1: 1) for 5 hours embedded plastic recommended by Spurr....
Abstract Polyprotein processing of plus‐strand RNA viruses is important in the regulation gene production and replication. The core protein hepatitis C virus (HCV), constructing viral particle, processed from its precursor polyprotein observed as two forms, p23 p21. Production p21 by cleavage at C‐terminus considered crucial to assembly In this study, step was compared between clones isolated patients with fulminant five chronic an vitro translation assay cell transfection assay. predominant...
Abstract We previously reported that 12.5% of primary biliary cirrhosis (PBC) sera reacted with a 95 kDa cytosol protein (p95c) was subsequently identified as p97/valosin‐containing (VCP). The clinical features and course the six anti‐p97/VCP‐positive PBC patients Scheuer's stage 1 2 liver biopsies were monitored for an average 15 years. This group compared 50 did not have detectable anti‐VCP. Autoantibodies to full‐length recombinant p97/VCP assayed by immunoprecipitation. All anti‐VCP had...
We have reported previously that p95c, a novel 95-kDa cytosolic protein, was the target of autoantibodies in sera patients with autoimmune hepatic diseases. studied 30 were shown to immunoprecipitate 95 kDa protein from [(35)S]-methionine-labelled HeLa lysates and had specific precipitin band immunodiffusion. Thirteen available test ability p95c antibodies inhibit nuclear envelope assembly an vitro assay which confocal fluorescence microscopy also used identify stages at inhibited. The...
AIMTo survey the efficacy and safety of dual therapy with daclatasvir asunaprevir in elderly hepatitis C virus (HCV) patients multicentricity. METHODSInterferon-ineligible/intolerant non-responders to previous pegylated-interferon/ribavirin chronic HCV genotype 1b infection were enrolled.Child B, cirrhotic excluded.
A 51-year-old man visited our hospital with a main complaint of precordial pain, difficulty swallowing, and pyrexia. The patient was diagnosed esophageal carcinosarcoma, based on the characteristic morphology noted upper gastrointestinal endoscopy histology tests, he underwent surgical treatment. His preoperative blood granulocyte-colony stimulating factor (G-CSF) interleukin-6 (IL-6) levels were high, specimens positive in both immunohistochemical tests; therefore, G-CSF- IL-6-producing...
ABSTRACT Prey depletion threatens many carnivore species across the world and can especially threaten low‐density subordinate competitors, particularly if subordinates are limited to low densities by their dominant competitors. Understanding mechanisms that drive responses of density prey is not only crucial for conservation but also elucidates balance between top‐down bottom‐up limitations within large guild. To avoid predation, competitively African wild dogs typically competitors (lions)...
To elucidate the precise immunological features in primary biliary cirrhosis (PBC), we examined relative prevalence of CD4+ T cells either symptomatic PBC (sPBC) or asymptomatic patients (aPBC), and furthermore, these results were compared with their histological features.Cytokine synthesis peripheral blood mononuclear obtained from 24 (9 sPBC 15 aPBC) by intracellular staining method. The three distinct cells, gamma-interferon (IFN-gamma)-producing (Th1), interleukin-4 (IL-4)-producing...
Abstract Large carnivores such as the lion are declining across Africa, in part because their large herbivore prey is declining. There consensus that increased protection from depletion will be necessary to reverse decline of populations, but few studies have tested whether sufficient decline, particularly large, open ecosystems where most lions remain. Here, we used an integrated population model test demography and dynamics were measurably improved by protection. We data monitoring 358...