A5021738634- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Treatments and Mutations
- Health, Environment, Cognitive Aging
- Health disparities and outcomes
- Ferroptosis and cancer prognosis
- Pregnancy and preeclampsia studies
- Autophagy in Disease and Therapy
- Pancreatic and Hepatic Oncology Research
- Genomics, phytochemicals, and oxidative stress
- Endoplasmic Reticulum Stress and Disease
- Birth, Development, and Health
Shandong University
2025
Jilin University
2020-2023
First Hospital of Jilin University
2020-2023
Abstract Background Lung cancer is one of the most lethal cancers worldwide. Cisplatin, a widely used anti‐lung drug, has been limited in clinical application due to its drug resistance. Medicines targeting mitochondrial electron transport chain (ETC) complexes may be effective candidates for cisplatin‐based chemotherapy. Methods In this study, small molecule library from Food and Drug Administration FDA was screen medicines ETC. MTT colony formation assays were investigate cell...
BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is a life-threatening digestive tract malignancy with no known curative treatment. This study aimed to investigate the antineoplastic effects of omipalisib and its underlying molecular mechanisms in ESCC using high throughput screen. MATERIAL AND METHODS:MTT assay clone formation were used determine viability proliferation. Flow cytometry was conducted detect cycle distribution apoptosis. Global gene expression mRNA levels determined by...
The prognosis and survival of lung adenocarcinoma (LUAD) patients are still not promising despite recent breakthroughs in treatment. Endoplasmic reticulum stress (ERS) is a self-protective mechanism resulting from an imbalance quality control unfolded proteins when cells stressed, which plays active role cancer development, but the relationship between ERS pathological characteristics clinical LUAD remains unclear.LASSO Cox regression were applied based on sequencing information to construct...