A5100341343- Adipose Tissue and Metabolism
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- vaccines and immunoinformatics approaches
- Tracheal and airway disorders
- Hydrology and Drought Analysis
- Acute Ischemic Stroke Management
- Adrenal Hormones and Disorders
- Aquaculture Nutrition and Growth
- Phytochemicals and Antioxidant Activities
- Metabolomics and Mass Spectrometry Studies
- Dysphagia Assessment and Management
- Reproductive biology and impacts on aquatic species
- Statistical Distribution Estimation and Applications
- Pituitary Gland Disorders and Treatments
- Viral Infections and Immunology Research
- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Stroke Rehabilitation and Recovery
- Cardiac Fibrosis and Remodeling
- Dyeing and Modifying Textile Fibers
- Metabolism, Diabetes, and Cancer
- Plant Gene Expression Analysis
- Water Systems and Optimization
Children's Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Fudan University
2018-2025
Zhongshan Hospital
2011-2025
Shanghai Jiao Tong University
2025
Shanghai First People's Hospital
2025
Shandong University
2025
Guangzhou University of Chinese Medicine
2023-2024
Huashan Hospital
2021-2022
State Key Laboratory of Genetic Engineering
2018-2022
Activating the thermogenic function of adipocytes is an attractive therapeutic strategy against obesity and its associated metabolic complications. Proanthocyanidins are a class polyphenols which widely found in plants daily foods. This aim this study to investigate modulatory effects grape seed proanthocyanidin extract (GSPE) on brown adipose tissue (BAT) activity, browning white (WAT) microbiome regulation high-fat diet (HFD)-fed mice molecular mechanism. An 8-week administration GSPE at...
Brown and beige fat are specialized for energy expenditure by dissipating from glucose fatty acid oxidation as heat. While metabolism have been extensively studied in thermogenic adipose tissues, the involvement of amino acids regulating adaptive thermogenesis remains little studied. Here, we report that asparagine supplementation brown adipocytes drastically upregulated transcriptional program lipogenic gene expression, so asparagine-fed mice showed better cold tolerance. In with...
Emerging evidence indicates that irisin provides beneficial effects in diabetes. However, whether influences the development of diabetic cardiomyopathy (DCM) remains unclear. Therefore, we investigated potential role and mechanism action diabetes-induced myocardial dysfunction mice. Type 1 diabetes was induced mice by injecting streptozotocin, were administered recombinant r-irisin (low or high dose: 0.5 1.5 μg/g body weight/day, I.P.) PBS for 16 weeks. Irisin treatment did not alter blood...
Fruits of Lycium ruthenicum (LR) and L. barbarum (LB) in Solanaceae family contain abundant bioactive metabolites used widely as functional food natural medicine. To characterize the fruit developmental molecular phenotypes, we comprehensively analyzed metabolite composition both fruits at three stages using combined NMR, liquid chromatography–tandem mass spectrometry, gas chromatography-flame ionization detector/mass spectrometry methods. The metabonomes these were dominated by over 90...
Simultaneous analysis of multiple phosphorylated metabolites (phosphorylated metabolome) in biological samples is vital to reveal their physiological and pathophysiological functions, which extremely challenging due low abundance some matrices, high hydrophilicity, poor chromatographic behavior. Here, we developed a new method with ion-pair reversed-phase ultrahigh-performance liquid chromatography mass spectrometry using BEH C18 columns modified hybrid surface technology. This demonstrated...
Background Stroke-associated pneumonia (SAP) remains a neglected area despite its high morbidity and mortality. We aimed to establish an easy-to-use model for predicting SAP. Methods Two hundred seventy-five acute ischemic stroke (AIS) patients were enrolled, 73 (26.55%) diagnosed with T -test, Chi-square test Fisher’s exact used investigate the associations of patient characteristics severity, multivariable logistic regression models construct prediction scale. Results Three variables most...
To explore how nutritional status impacts treatment efficacy and future asthma risk in infants with bronchiolitis. A retrospective analysis of 473 RSV-induced bronchiolitis cases from 2015 to 2018. No significant demographic differences. Obese showed increased respiratory distress, wheezing, rapid breathing, lower oxygen saturation. Elevated IgE tumor necrosis factor-α (TNF-α) levels persisted the obese group. higher incidence was observed after 5 years this Nutritional is crucial for...
This study aimed to evaluate the relative validity and reproducibility of a semiquantitative food frequency questionnaire (SFFQ) in adult populations China. Among 49 recruited healthy participants (age range: 20-60 years), 79-item SFFQ was assessed two ways: (1) by comparing its dietary intake estimates with those from average measurements three inconsecutive 24 h records (24-HDRs); (2) fatty acids measured plasma levels acids. The evaluated comparison same collected one year apart. In...
Stroke has been the leading cause of death and disability in world. Early recognition treatment stroke could effectively limit brain damage vastly improve outcomes. This study aims to develop a highly accurate prediction model with list lifestyle behaviors clinical characteristics distinguish high-risk groups community-dwelling population.Participants this longitudinal cohort came from population Suzhou between November 2018 June 2019. A total 4,503 residents participated study, while...
Influenza A virus (IAV), one of the most prevalent respiratory diseases, causes pandemics around world. The multifunctional non-structural protein 1 (NS1) IAV is a viral antagonist that suppresses host antiviral response. However, mechanism by which NS1 modulates RNA interference (RNAi) pathway remains unclear. Here, we identified interactions between proteins A/PR8/34 (H1N1; IAV-PR8) and A/WSN/1/33 IAV-WSN) Dicer’s cofactor TAR-RNA binding (TRBP). We found N-terminal domain (RBD) first two...
There are seven human-adaptation lineages of Mycobacterium tuberculosis (Mtb). Tuberculosis (TB) dissemination is strongly influenced by human movements and host genetics. The detailed lineage distribution evolution Mtb in Zhejiang Province unknown. We aim to determine how different sub-lineages transmitted distributed within China Province.We analysed whole-genome sequencing data for a worldwide collection 1154 isolates provincial 1296 isolates, constructed the best-scoring maximum...
Influenza A virus (IAV) causes seasonal infections and periodic pandemics in humans. The non-structural protein 1 (NS1) of IAV is the main viral antagonist innate immune responses that play a key role influenza pathogenesis. However, mechanism to disrupt host cell homeostasis by NS1 remains poorly understood. Here, we show expression from WSN strain, but not PR8 IAV, markedly induced nuclear import RNA interference (RNAi) factors such as Argonaute-2 microRNA 16. We found single residue...
Bayesian and Empirical estimatiors of the parameter one-parameter exponential distribution are obtained under a precautionary loss function based on progressively Type-II censored samples. The admissibility inadmissibility estimatrors with linear form also discussed.
Abstract Background: Stroke-associated pneumonia (SAP) remains a neglected area despite its high morbidity and mortality. We aimed to establish an easy-to-use model for predicting SAP severity. Methods: 275 acute ischemic stroke (AIS) patients were enrolled, 73 (26.55%) diagnosed with SAP. T -test, Chi-square test Fisher’s exact used investigate the associations of patient characteristics severity, multivariable logistic regression models construct prediction scale. Results: Three variables...